scholarly journals Angiotensin II type 2 receptors have a major somatodendritic distribution in vasopressin-containing neurons in the mouse hypothalamic paraventricular nucleus

Neuroscience ◽  
2009 ◽  
Vol 163 (1) ◽  
pp. 129-142 ◽  
Author(s):  
C.G. Coleman ◽  
J. Anrather ◽  
C. Iadecola ◽  
V.M. Pickel
Keyword(s):  
Angiotensin Ii ◽  
Paraventricular Nucleus ◽  
Hypothalamic Paraventricular Nucleus

scholarly journals Orexin depolarizes rat hypothalamic paraventricular nucleus neurons

2001 ◽  
Vol 281 (4) ◽  
pp. R1114-R1118 ◽  
Author(s):  
Tetsuro Shirasaka ◽  
Satoshi Miyahara ◽  
Takato Kunitake ◽  
Qing-Hua Jin ◽  
Kazuo Kato ◽  
...  
Keyword(s):  
Paraventricular Nucleus ◽  
Brain Slices ◽  
Hypothalamic Paraventricular Nucleus ◽  
Dependent Manner ◽  
Patch Clamp Recording ◽  
Concentration Dependent Manner ◽  
Whole Cell Patch Clamp ◽  
Orexin Receptors ◽  
Bath Application

Orexins, also called hypocretins, are newly discovered hypothalamic peptides that are thought to be involved in various physiological functions. In spite of the fact that orexin receptors, especially orexin receptor 2, are abundant in the hypothalamic paraventricular nucleus (PVN), the effects of orexins on PVN neurons remain unknown. Using a whole cell patch-clamp recording technique, we investigated the effects of orexin-B on PVN neurons of rat brain slices. Bath application of orexin-B (0.01–1.0 μM) depolarized 80.8% of type 1 ( n = 26) and 79.2% of type 2 neurons tested ( n = 24) in the PVN in a concentration-dependent manner. The effects of orexin-B persisted in the presence of TTX (1 μM), indicating that these depolarizing effects were generated postsynaptically. Addition of Cd2+(1 mM) to artificial cerebrospinal fluid containing TTX (1 μM) significantly reduced the depolarizing effect in type 2 neurons. These results suggest that orexin-B has excitatory effects on the PVN neurons mediated via a depolarization of the membrane potential.

scholarly journals 11β-Hydroxysteroid Dehydrogenase Type 2 Activity in Hypothalamic Paraventricular Nucleus Modulates Sympathetic Excitation

Hypertension ◽  
2006 ◽  
Vol 48 (1) ◽  
pp. 127-133 ◽  
Author(s):  
Zhi-Hua Zhang ◽  
Yu-Ming Kang ◽  
Yang Yu ◽  
Shun-Guang Wei ◽  
Thomas J. Schmidt ◽  
...  
Keyword(s):  
Paraventricular Nucleus ◽  
Hydroxysteroid Dehydrogenase ◽  
Hypothalamic Paraventricular Nucleus

Estrogen decreases the responsiveness of subfornical organ neurons projecting to the hypothalamic paraventricular nucleus to angiotensin II in female rats

2001 ◽  
Vol 307 (3) ◽  
pp. 155-158 ◽  
Author(s):  
Junichi Tanaka ◽  
Hiroko Miyakubo ◽  
Takefumi Okumura ◽  
Kazuhiro Sakamaki ◽  
Yasushi Hayashi
Keyword(s):  
Angiotensin Ii ◽  
Paraventricular Nucleus ◽  
Subfornical Organ ◽  
Hypothalamic Paraventricular Nucleus ◽  
Female Rats
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