scholarly journals Association between lesion location and language function in adult glioma using voxel-based lesion-symptom mapping

2015 ◽  
Vol 9 ◽  
pp. 617-624 ◽  
Author(s):  
Pia Banerjee ◽  
Kevin Leu ◽  
Robert J. Harris ◽  
Timothy F. Cloughesy ◽  
Albert Lai ◽  
...  
PLoS ONE ◽  
2013 ◽  
Vol 8 (4) ◽  
pp. e60541 ◽  
Author(s):  
J. Matthijs Biesbroek ◽  
Hugo J. Kuijf ◽  
Yolanda van der Graaf ◽  
Koen L. Vincken ◽  
Albert Postma ◽  
...  

Neurology ◽  
2019 ◽  
Vol 93 (16) ◽  
pp. e1561-e1571 ◽  
Author(s):  
Fatimah M. Albazron ◽  
Joel Bruss ◽  
Robin M. Jones ◽  
Torunn I. Yock ◽  
Margaret B. Pulsifer ◽  
...  

ObjectiveTo evaluate lesion location after pediatric cerebellar tumor resection in relation to the development of severe cognitive and affective disturbances, or cerebellar cognitive affective syndrome (CCAS).MethodsThe postsurgical lesion location of 195 pediatric patients with cerebellar tumors was mapped onto a template brain. Individuals with CCAS were matched to 2 participants without CCAS by sex, age, and lesion volume. Lesion analyses included both a hypothesis-driven evaluation of the cerebellar outflow pathway (deep nuclei and superior cerebellar peduncles) and data-driven multivariate lesion symptom mapping. Lesion-associated networks were evaluated by comparing connectivity patterns between the lesion location of cases with and those without CCAS with resting-state functional connectivity MRI data from large normative adult and pediatric cohorts.ResultsCCAS was present in 48 of 195 participants (24.6%) and was strongly associated with cerebellar outflow tract lesions (p < 0.0001). Lesion symptom mapping also highlighted the cerebellar outflow pathway, with peak findings in the fastigial nuclei extending into the inferior vermis. Lesion network mapping revealed that the cerebellar region most associated with CCAS was functionally connected to the thalamic mediodorsal nucleus, among other sites, and that higher connectivity between lesion location and the mediodorsal nucleus predicts CCAS occurrence (p < 0.01). A secondary analysis of 27 participants with mutism revealed similar localization of lesions and lesion-associated networks.ConclusionLesions of the cerebellar outflow pathway and inferior vermis are associated with major cognitive and affective disturbances after pediatric cerebellar tumor resection, and disrupted communication between the cerebellum and the thalamic mediodorsal nucleus may be important.


Stroke ◽  
2014 ◽  
Vol 45 (suppl_1) ◽  
Author(s):  
Kimberly Shibuya ◽  
Erin Burke ◽  
Lucy Dodakian ◽  
Jill See ◽  
Steven C Cramer ◽  
...  

Background and Purpose: We used voxel-based lesion symptom mapping (VLSM) to determine the relationship between lesion location and performance on upper extremity behavioral outcome measures post-stroke. We hypothesized that a lesion within the upper extremity region of the primary motor cortex would correlate with poorer hand motor outcome measures. Methods: Thirty-six chronic stroke survivors with upper extremity motor deficits who underwent 3 weeks of hand/wrist robotic therapy were included in the study. Behavioral motor outcome measures included: Fugl-Meyer Arm (FMA) Test, Action Research Arm Test (ARAT), and Box & Blocks Test (BB). Anatomical imaging included a high-resolution T1-weighted volumetric scan and a T2-weighted scan. Lesioned areas were manually traced using MRIcron; stroke masks were flipped to left and binarized. All of the subjects’ T1-weighted images were transformed to Montreal Neurological Institute (MNI) standardized stereotaxic space. Data were analyzed using the non-parametric mapping (NPM) software package in MRIcron with the Brunner-Munzel test set at 1,000 permutations and a 10% threshold. The threshold for the overlap between low behavioral scores and related brain regions was set at α= 0.01. Results: Lesions in the inferior frontal gyrus and underlying white matter and the posterior limb of the internal capsule (PLIC) correlated with poorer motor outcomes on the FMA and ARAT, indicating a degree of anatomical overlap between impairment and activity levels of upper extremity motor performance. Lesions of the premotor area also correlated with poorer ARAT outcomes, whereas lesions of the middle frontal gyrus and underlying white matter correlated with poorer performance on the BB, reflecting the role that motor planning plays in those activities. Conclusions: Voxel-Based Symptom Mapping adds a new dimension in clarifying the specific lesion location associated with dexterous motor function post-stroke. Activity vs. impairment deficits relate to lesions in anatomical areas involved in motor planning vs. those involved in movement execution.


2010 ◽  
Vol 41 (9) ◽  
pp. 2
Author(s):  
SHARON WORCESTER
Keyword(s):  

2020 ◽  
Vol 19 (10) ◽  
pp. 943-948
Author(s):  
Peter Lio ◽  
Andreas Wollenberg ◽  
Jacob Thyssen ◽  
Evangeline Pierce ◽  
Maria Rueda ◽  
...  

Author(s):  
Ruth Garrett Millikan

This book weaves together themes from natural ontology, philosophy of mind, philosophy of language and information, areas of inquiry that have not recently been treated together. The sprawling topic is Kant’s how is knowledge possible? but viewed from a contemporary naturalist standpoint. The assumption is that we are evolved creatures that use cognition as a guide in dealing with the natural world, and that the natural world is roughly as natural science has tried to describe it. Very unlike Kant, then, we must begin with ontology, with a rough understanding of what the world is like prior to cognition, only later developing theories about the nature of cognition within that world and how it manages to reflect the rest of nature. And in trying to get from ontology to cognition we must traverse another non-Kantian domain: questions about the transmission of information both through natural signs and through purposeful signs including, especially, language. Novelties are the introduction of unitrackers and unicepts whose job is to recognize the same again as manifested through the jargon of experience, a direct reference theory for common nouns and other extensional terms, a naturalist sketch of uniceptual—roughly conceptual— development, a theory of natural information and of language function that shows how properly functioning language carries natural information, a novel description of the semantics/pragmatics distinction, a discussion of perception as translation from natural informational signs, new descriptions of indexicals and demonstratives and of intensional contexts and a new analysis of the reference of incomplete descriptions.


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