scholarly journals Behavioral memory induced by stimulation of the nucleus basalis: Effects of contingency reversal

2009 ◽  
Vol 91 (3) ◽  
pp. 298-309 ◽  
Author(s):  
Alexandre A. Miasnikov ◽  
Jemmy C. Chen ◽  
Norman M. Weinberger
Keyword(s):  
Nucleus Basalis ◽  
Behavioral Memory ◽  
Contingency Reversal ◽  
Stimulation Of

scholarly journals Motivationally neutral stimulation of the nucleus basalis induces specific behavioral memory

2008 ◽  
Vol 90 (1) ◽  
pp. 125-137 ◽  
Author(s):  
Alexandre A. Miasnikov ◽  
Jemmy C. Chen ◽  
Nataliya Gross ◽  
Bonnie S. Poytress ◽  
Norman M. Weinberger
Keyword(s):  
Nucleus Basalis ◽  
Behavioral Memory ◽  
Stimulation Of

scholarly journals Electrical stimulation of the nucleus basalis of meynert: a systematic review of preclinical and clinical data

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Muhammad Nazmuddin ◽  
Ingrid H. C. H. M. Philippens ◽  
Teus van Laar
Keyword(s):  
Electrical Stimulation ◽  
Clinical Data ◽  
Animal Studies ◽  
Receptive Fields ◽  
Lewy Body Dementia ◽  
Clinical Situation ◽  
Nucleus Basalis ◽  
Nucleus Basalis Of Meynert ◽  
Clinical Effects ◽  
Stimulation Of

AbstractDeep brain stimulation (DBS) of the nucleus basalis of Meynert (NBM) has been clinically investigated in Alzheimer’s disease (AD) and Lewy body dementia (LBD). However, the clinical effects are highly variable, which questions the suggested basic principles underlying these clinical trials. Therefore, preclinical and clinical data on the design of NBM stimulation experiments and its effects on behavioral and neurophysiological aspects are systematically reviewed here. Animal studies have shown that electrical stimulation of the NBM enhanced cognition, increased the release of acetylcholine, enhanced cerebral blood flow, released several neuroprotective factors, and facilitates plasticity of cortical and subcortical receptive fields. However, the translation of these outcomes to current clinical practice is hampered by the fact that mainly animals with an intact NBM were used, whereas most animals were stimulated unilaterally, with different stimulation paradigms for only restricted timeframes. Future animal research has to refine the NBM stimulation methods, using partially lesioned NBM nuclei, to better resemble the clinical situation in AD, and LBD. More preclinical data on the effect of stimulation of lesioned NBM should be present, before DBS of the NBM in human is explored further.

Autoradiographic Evidence for Flow-Metabolism Uncoupling During Stimulation of the Nucleus Basalis of Meynert in the Conscious Rat

1997 ◽  
Vol 17 (6) ◽  
pp. 686-694 ◽  
Author(s):  
Elvire Vaucher ◽  
Josiane Borredon ◽  
Gilles Bonvento ◽  
Jacques Seylaz ◽  
Pierre Lacombe
Keyword(s):  
Blood Flow ◽  
Electrical Stimulation ◽  
Metabolic Activity ◽  
Nucleus Basalis ◽  
Nucleus Basalis Of Meynert ◽  
Conscious Rat ◽  
Local Flow ◽  
Cortical Blood Flow ◽  
Subcortical Regions ◽  
Stimulation Of

We earlier reported that electrical stimulation of the rat nucleus basalis of Meynert (NBM) induces large cerebral blood flow increases, particularly in frontal cortical areas but also in some subcortical regions. The present study was designed to address the issue of blood flow control exerted by NBM projections. To this aim, we have determined whether these flow increases were associated with proportionate changes in metabolic activity as evaluated by cerebral glucose utilization (CGU) strictly under the same experimental conditions in the conscious rat. An electrode was chronically implanted in a reactive site of the NBM as determined by laser-Doppler flowmetry (LDF) of the cortical circulation. One to two weeks later, while the cortical blood flow was monitored by LDF, we measured CGU using the [14C]2-deoxyglucose autoradiographic technique during unilateral electrical stimulation of the NBM, and analyzed the local flow-metabolism relationship. The large increases in cortical blood flow induced by NBM stimulation, exceeding 300% in various frontal areas, were associated with at most 24% increases in CGU (as compared with the control group) in one frontal area. By contrast, strong increases in CGU exceeding 150% were observed in subcortical regions ipsilateral to the stimulation, especially in extrapyramidal structures, associated with proportionate CBF changes. Thus, none of the blood flow changes observed in the cortex can be ascribed to an increased metabolic activity, whereas CBF and CGU were coupled in many subcortical areas. This result indicates that different mechanisms, which do not necessarily involve any metabolic factor, contribute to the regulation of the cerebral circulation at the cortical and subcortical level. Because the distribution of the uncoupling is coincident with that of cholinergic NBM projections directly reaching cortical microvessels, these data strongly support the hypothesis that NBM neurons are capable of exerting a neurogenic control of the cortical microcirculation.

scholarly journals Acetylcholine is released in the basolateral amygdala in response to predictors of reward and enhances learning of cue-reward contingency

2020 ◽  
Author(s):  
Richard B. Crouse ◽  
Kristen Kim ◽  
Hannah M. Batchelor ◽  
Rufina Kamaletdinova ◽  
Justin Chan ◽  
...  
Keyword(s):  
Basolateral Amygdala ◽  
Nucleus Basalis ◽  
Reward Learning ◽  
Neuron Activity ◽  
Reward Contingency ◽  
Emotional Stimuli ◽  
Rapid Learning ◽  
Calcium Indicators ◽  
Task Acquisition ◽  
Stimulation Of

AbstractThe basolateral amygdala (BLA) is critical for associating initially neutral cues with appetitive and aversive stimuli and receives dense neuromodulatory acetylcholine (ACh) projections. We measured BLA ACh signaling and principal neuron activity in mice during cue-reward learning using a fluorescent ACh sensor and calcium indicators. We found that ACh levels and activity of nucleus basalis of Meynert (NBM) cholinergic terminals in the BLA (NBM-BLA) increased sharply in response to reward-related events and shifted as mice learned the tone-reward contingency. BLA principal neuron activity followed reward retrieval and moved to the reward-predictive tone after task acquisition. Optical stimulation of cholinergic NBM-BLA terminal fibers during cue-reward learning led to more rapid learning of the cue-reward contingency. These results indicate that BLA ACh signaling carries important information about salient events in cue-reward learning and provides a framework for understanding how ACh signaling contributes to shaping BLA responses to emotional stimuli.

scholarly journals Cholinergic upregulation by optogenetic stimulation of nucleus basalis after photothrombotic stroke in forelimb somatosensory cortex improves endpoint and motor but not sensory control of skilled reaching in mice

2020 ◽  
Author(s):  
Behroo Mirza Agha ◽  
Roya Akbary ◽  
Arashk Ghasroddashti ◽  
Mojtaba Nazari-Ahangarkolaee ◽  
Ian Q. Whishaw ◽  
...  
Keyword(s):  
Somatosensory Cortex ◽  
Sensorimotor Integration ◽  
Motor Behavior ◽  
Field Potential ◽  
Cholinergic Neurons ◽  
Nucleus Basalis ◽  
Optogenetic Stimulation ◽  
Photothrombotic Stroke ◽  
Skilled Reaching ◽  
Stimulation Of

AbstractA network of cholinergic neurons in the basal forebrain innerve the forebrain and are proposed to contribute to a variety of functions including attention, and cortical plasticity. This study examined the contribution of the nucleus basalis cholinergic projection to the sensorimotor cortex on recovery on a skilled reach-to-eat task following photothrombotic stroke in the forelimb region of the somatosensory cortex. Mice were trained to perform a single-pellet skilled reaching task and their pre and poststroke performance, from Day 4 to Day 28 poststroke, was assessed frame-by-frame by video analysis with end point, movement and sensorimotor integration measures. Somatosensory forelimb lesions produced impairments in endpoint and movement component measures of reaching and increased the incidence of fictive eating, a sensory impairment in mistaking a missed reach for a successful reach. Upregulated acetylcholine (ACh) release, as measured by local field potential recording, elicited via optogenetic stimulation of the nucleus basalis improved recovery of reaching and improved movement scores but did not affect a sensorimotor integration impairment poststroke. The results show that the mouse cortical forelimb somatosensory region contributes to forelimb motor behavior and suggest that ACh upregulation could serve as an adjunct to behavioral therapy for the acute treatment of stroke.

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