Remote context fear conditioning remains hippocampus-dependent irrespective of training protocol, training–surgery interval, lesion size, and lesion method

2013 ◽  
Vol 106 ◽  
pp. 300-308 ◽  
Author(s):  
Nicola J. Broadbent ◽  
Robert E. Clark
Keyword(s):  
Fear Conditioning ◽  
Lesion Size ◽  
Lesion Method ◽  
Training Protocol ◽  
Context Fear Conditioning

scholarly journals Protein Profiles Associated With Context Fear Conditioning and Their Modulation by Memantine

2014 ◽  
Vol 13 (4) ◽  
pp. 919-937 ◽  
Author(s):  
Md. Mahiuddin Ahmed ◽  
A. Ranjitha Dhanasekaran ◽  
Aaron Block ◽  
Suhong Tong ◽  
Alberto C. S. Costa ◽  
...  
Keyword(s):  
Fear Conditioning ◽  
Protein Profiles ◽  
Context Fear Conditioning

scholarly journals Dentate Gyrus Contributes to Retrieval as well as Encoding: Evidence from Context Fear Conditioning, Recall, and Extinction

2017 ◽  
Vol 37 (26) ◽  
pp. 6359-6371 ◽  
Author(s):  
Brian E. Bernier ◽  
Anthony F. Lacagnina ◽  
Adam Ayoub ◽  
Francis Shue ◽  
Boris V. Zemelman ◽  
...  
Keyword(s):  
Dentate Gyrus ◽  
Fear Conditioning ◽  
Context Fear Conditioning

scholarly journals Context Fear Conditioning in Down Syndrome Mouse Models: Effects of Trisomic Gene Content, Age, Sex and Genetic Background

Genes ◽  
2021 ◽  
Vol 12 (10) ◽  
pp. 1528
Author(s):  
Md. Mahiuddin Ahmed ◽  
Aaron Block ◽  
Nicolas Busquet ◽  
Katheleen J. Gardiner
Keyword(s):  
Down Syndrome ◽  
Fear Conditioning ◽  
Mouse Models ◽  
Genetic Background ◽  
Chromosome 21 ◽  
F1 Hybrids ◽  
Male Mice ◽  
Human Chromosome 21 ◽  
The Common ◽  
Context Fear Conditioning

Down syndrome (DS), trisomy of the long arm of human chromosome 21 (Hsa21), is the most common genetic cause of intellectual disability (ID). Currently, there are no effective pharmacotherapies. The success of clinical trials to improve cognition depends in part on the design of preclinical evaluations in mouse models. To broaden understanding of the common limitations of experiments in learning and memory, we report performance in context fear conditioning (CFC) in three mouse models of DS, the Dp(16)1Yey, Dp(17)1Yey and Dp(10)1Yey (abbreviated Dp16, Dp17 and Dp10), separately trisomic for the human Hsa21 orthologs mapping to mouse chromosomes 16, 17 and 10, respectively. We examined female and male mice of the three lines on the standard C57BL/6J background at 3 months of age and Dp17 and Dp10 at 18 months of age. We also examined female and male mice of Dp17 and Dp10 at 3 months of age as F1 hybrids obtained from a cross with the DBA/2J background. Results indicate that genotype, sex, age and genetic background affect CFC performance. These data support the need to use both female and male mice, trisomy of sets of all Hsa21 orthologs, and additional ages and genetic backgrounds to improve the reliability of preclinical evaluations of drugs for ID in DS.

Context fear conditioning inhibits panic-like behavior elicited by electrical stimulation of dorsal periaqueductal gray

Neuroreport ◽  
2003 ◽  
Vol 14 (12) ◽  
pp. 1641-1644 ◽  
Author(s):  
Valeska Magierek ◽  
Patrício L. Ramos ◽  
Nylson G. da Silveira-Filho ◽  
Regina L. Nogueira ◽  
J. Landeira-Fernandez
Keyword(s):  
Electrical Stimulation ◽  
Fear Conditioning ◽  
Periaqueductal Gray ◽  
Dorsal Periaqueductal Gray ◽  
Stimulation Of ◽  
Context Fear Conditioning

scholarly journals Dissociable Roles for the Hippocampus and the Amygdala in Human Cued versus Context Fear Conditioning

2008 ◽  
Vol 28 (36) ◽  
pp. 9030-9036 ◽  
Author(s):  
A. Marschner ◽  
R. Kalisch ◽  
B. Vervliet ◽  
D. Vansteenwegen ◽  
C. Buchel
Keyword(s):  
Fear Conditioning ◽  
Context Fear Conditioning
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