Muscle weakness, joint laxity and keloids. A more than suggestive association

SummaryA few investigations in the 1960’s were performed to document the effect of exogenous oestrogens on development of hip dysplasia. These projects concluded that oestrogen administration caused a significant increase in hip dysplasia. Additionally, the Orthopaedic Foundation for Animals (OFA) has recommended that bitches should not have hip evaluation for certification during oestrus, due to the possibility of increased coxofemoral joint laxity. The purpose of this project was to determine if physiological fluctuations of oestrogen and progesterone throughout the oestrus cycle significantly affected coxofemoral joint laxity. Nine bitches were evaluated through a single oestrus cycle. Although significant fluctuations of oestrogen and progesterone occurred throughout the phases of the oestrus cycle, neither statistically nor clinically significant changes in coxofemoral joint laxity were documented.A prospective study documented the effect of fluctuations of hormone levels throughout the oestrus cycle on coxofemoral joint laxity in nine dogs. Although oestrogen and progesterone levels changed significantly throughout the oestrus cycle, neither statistically nor clinically significant changes in hip laxity were observed.

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Do children with mild to moderate osteogenesis imperfecta (OI) with abdominal muscle weakness have a higher incidence of pars defects? A physiotherapy pilot

Bone Abstracts ◽

10.1530/boneabs.4.p151 ◽

2015 ◽

Author(s):

Emilie Hupin ◽

Karen Edwards ◽

Moira Chueng ◽

Jeremy Allgrove ◽

Catherine DeVile

Keyword(s):

Osteogenesis Imperfecta ◽

Muscle Weakness ◽

Abdominal Muscle

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Biological therapy in idiopathic inflammatory myopathies

Orvosi Hetilap ◽

10.1556/oh.2014.29787 ◽

2014 ◽

Vol 155 (1) ◽

pp. 3-10

Author(s):

Levente Bodoki ◽

Melinda Nagy-Vincze ◽

Zoltán Griger ◽

Andrea Péter ◽

Csilla András ◽

...

Keyword(s):

T Cells ◽

Muscle Weakness ◽

Biological Therapy ◽

Therapeutic Options ◽

Idiopathic Inflammatory Myopathies ◽

Inflammatory Myopathies ◽

Progressive Muscle Weakness ◽

Immune Mediated ◽

Novel Therapeutic

Idiopathic inflammatory myopathies are systemic, immune-mediated diseases characterized by proximal, symmetrical, progressive muscle weakness. The aim of this work is to give an overview of the biological therapy used in the treatment of idiopathic inflammatory myopathies. The authors also focus on novel results in the therapy directed against the B- and T-cells. They emphasize the importance of new trials in these diseases which may lead to the introduction of novel therapeutic options in these disorders. Orv. Hetil., 2014, 155(1), 3–10.

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4 Case Reports On Patients with Acute Lower Limb Muscle Weakness Treated by Spinal Mobilization With Leg Movement(SMWLM) Combined with Korean Medicine Treatment

10.30581/jcmm.2020.15.2.63 ◽

2020 ◽

Vol 15 (2) ◽

pp. 63-73

Author(s):

Young-Joo Moon ◽

Won-Bin Shin ◽

Gwang-Hyun Ryu ◽

Ji-Yun Lee ◽

Hyun-A Jeon ◽

...

Keyword(s):

Muscle Weakness ◽

Lower Limb ◽

Case Reports ◽

Lower Limb Muscle ◽

Limb Muscle ◽

Korean Medicine ◽

Leg Movement

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Tropomyosin mutations responsible for muscle weakness in inherited skeletal muscle diseases

10.36866/pn.69.20 ◽

2008 ◽

pp. 20-21

Author(s):

Julien Ochala ◽

Anders Oldfors ◽

Lars Larsson

Keyword(s):

Skeletal Muscle ◽

Muscle Weakness ◽

Muscle Diseases

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Replication study and meta-analysis indicate a suggestive association of RUNX3 locus with primary biliary cholangitis

Immunogenetics ◽

10.1007/s00251-020-01192-4 ◽

2020 ◽

Author(s):

Rohil Jawed ◽

Mingming Zhang ◽

Chan Wang ◽

Shu-Han Yang ◽

Peng Jiang ◽

...

Keyword(s):

Meta Analysis ◽

Replication Study ◽

Primary Biliary Cholangitis ◽

Suggestive Association

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Cadaveric evaluation of the feasibility of glenohumeral joint denervation

Journal of Experimental Orthopaedics ◽

10.1186/s40634-020-00322-x ◽

2021 ◽

Vol 8 (1) ◽

Author(s):

Amr M. Aly

Keyword(s):

Muscle Weakness ◽

Shoulder Joint ◽

Glenohumeral Joint ◽

Axillary Nerve ◽

Low Risk ◽

Dorsal Approach ◽

Articular Branch ◽

Pectoral Nerve ◽

Teres Minor

Abstract Purpose To assess the feasibility of total shoulder denervation through two proposed incisions. Methods Total shoulder denervation was performed through an extended delta-pectoral approach and a transverse dorsal approach at the spine of the scapula. The study involved six cadavers. Course and number of articular branches from the lateral pectoral, axillary and supra-scapular nerve were documented. Results All shoulder joint articular branches were accessible through the proposed anterior and posterior approaches. The articular branch of the lateral pectoral nerve and supra scapular nerve were present in all the specimen. Axillary nerve articular branches were variable in number but when present anteriorly were proximal to the deltoid muscular branches and posteriorly proximal to the muscular branches to the teres minor. Conclusion Total glenohumeral denervation was feasible through our proposed anterior and posterior approaches. Enhanced knowledge of articular nerve branches could provide interventional targets for joint and ligament pain, with low risk of muscle weakness.

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Respiratory Muscle Weakness as a Risk Factor for Pneumonia in Older People

Gerontology ◽

10.1159/000514007 ◽

2021 ◽

pp. 1-10

Author(s):

Tatsuma Okazaki ◽

Yoshimi Suzukamo ◽

Midori Miyatake ◽

Riyo Komatsu ◽

Masahiro Yaekashiwa ◽

...

Keyword(s):

Risk Factor ◽

Muscle Strength ◽

Older People ◽

Serum Albumin ◽

Muscle Mass ◽

Muscle Weakness ◽

Fat Mass ◽

Respiratory Muscle ◽

Respiratory Muscle Strength ◽

Respiratory Muscle Weakness

Introduction: The respiratory muscle strength regulates the effectiveness of coughing, which clears the airways and protects people from pneumonia. Sarcopenia is an aging-related loss of muscle mass and function, the worsening of which is associated with malnutrition. The loss of respiratory and swallowing muscle strength occurs with aging, but its effect on pneumonia is unclear. This study aimed to determine the risks of respiratory muscle weakness on the onset and relapse of pneumonia in older people in conjunction with other muscle-related factors such as malnutrition. Methods: We conducted a longitudinal study with 47 pneumonia inpatients and 35 non-pneumonia controls aged 70 years and older. We evaluated the strength of respiratory and swallowing muscles, muscle mass, and malnutrition (assessed by serum albumin levels and somatic fat) during admission and confirmed pneumonia relapse within 6 months. The maximal inspiratory and expiratory pressures determined the respiratory muscle strength. Swallowing muscle strength was evaluated by tongue pressure. Bioelectrical impedance analysis was used to evaluate the muscle and fat mass. Results: The respiratory muscle strength, body trunk muscle mass, serum albumin level, somatic fat mass, and tongue pressure were significantly lower in pneumonia patients than in controls. Risk factors for the onset of pneumonia were low inspiratory respiratory muscle strength (odds ratio [OR], 6.85; 95% confidence interval [CI], 1.56–30.11), low body trunk muscle mass divided by height2 (OR, 6.86; 95% CI, 1.49–31.65), and low serum albumin level (OR, 5.46; 95% CI, 1.51–19.79). For the relapse of pneumonia, low somatic fat mass divided by height2 was a risk factor (OR, 20.10; 95% CI, 2.10–192.42). Discussion/Conclusions: Respiratory muscle weakness, lower body trunk muscle mass, and malnutrition were risk factors for the onset of pneumonia in older people. For the relapse of pneumonia, malnutrition was a risk factor.

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