Development of novel 67/68Ga-labeled pyridyl benzofuran derivatives as islet amyloid imaging probes

In continuation of our investigation of the dibenzylideneacetone scaffold as Aβ imaging probes, a series of derivatives containing pyridine rings with lower lipophilicity was synthesized and evaluated.

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2-Arylbenzothiazoles labeled with [CpRe/ 99m Tc(CO) 3 ] and evaluated as β -amyloid imaging probes

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2016.09.001 ◽

2016 ◽

Vol 124 ◽

pp. 763-772 ◽

Cited By ~ 16

Author(s):

Jianhua Jia ◽

Kaixiang Zhou ◽

Jiapei Dai ◽

Boli Liu ◽

Mengchao Cui

Keyword(s):

Amyloid Imaging ◽

Imaging Probes ◽

Β Amyloid

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Feasibility of Amylin Imaging in Pancreatic Islets with β-Amyloid Imaging Probes

Scientific Reports ◽

10.1038/srep06155 ◽

2014 ◽

Vol 4 (1) ◽

Cited By ~ 10

Author(s):

Masashi Yoshimura ◽

Masahiro Ono ◽

Hiroyuki Watanabe ◽

Hiroyuki Kimura ◽

Hideo Saji

Keyword(s):

Pancreatic Islets ◽

Amyloid Imaging ◽

Imaging Probes ◽

Β Amyloid

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Structural Analysis Reveals an Amyloid Form of the Human Papillomavirus Type 16 E1∧E4 Protein and Provides a Molecular Basis for Its Accumulation

Journal of Virology ◽

10.1128/jvi.00509-08 ◽

2008 ◽

Vol 82 (16) ◽

pp. 8196-8203 ◽

Cited By ~ 25

Author(s):

Pauline B. McIntosh ◽

Stephen R. Martin ◽

Deborah J. Jackson ◽

Jameela Khan ◽

Erin R. Isaacson ◽

...

Keyword(s):

Human Papillomavirus ◽

Structural Analysis ◽

Epithelial Cells ◽

Molecular Basis ◽

Hpv Infection ◽

Fibril Formation ◽

Amyloid Imaging ◽

Biopsy Material ◽

Human Papillomavirus Type 16 ◽

Imaging Probes

ABSTRACT The abundant human papillomavirus (HPV) type 16 E4 protein exists as two distinct structural forms in differentiating epithelial cells. Monomeric full-length 16E1∧E4 contains a limited tertiary fold constrained by the N and C termini. N-terminal deletions facilitate the assembly of E1∧E4 into amyloid-like fibrils, which bind to thioflavin T. The C-terminal region is highly amyloidogenic, and its deletion abolishes amyloid staining and prevents E1∧E4 accumulation. Amyloid-imaging probes can detect 16E1∧E4 in biopsy material, as well as 18E1∧E4 and 33E1∧E4 in monolayer cells, indicating structural conservation. Our results suggest a role for fibril formation in facilitating the accumulation of E1∧E4 during HPV infection.

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