Development of novel 67/68Ga-labeled pyridyl benzofuran derivatives as islet amyloid imaging probes

2022 ◽  
Author(s):  
Kosuke Saito ◽  
Hiroyuki Watanabe ◽  
Shimpei Iikuni ◽  
Masahiro Ono
Keyword(s):  
Amyloid Imaging ◽  
Islet Amyloid ◽  
Imaging Probes

( R )- and ( S )- 18 F-labeled 2-arylbenzofurans with improved pharmacokinetics as β -amyloid imaging probes

2017 ◽  
Vol 134 ◽  
pp. 271-280 ◽  
Author(s):  
Jia Song ◽  
Xiaoyang Zhang ◽  
Yunling Zhao ◽  
Hui Yang ◽  
Jinming Zhang ◽  
...  
Keyword(s):  
Amyloid Imaging ◽  
Imaging Probes ◽  
Β Amyloid

18F-labeled 2-phenylbenzoheterocycles with chiral dihydroxyl side chains as β-amyloid imaging probes

2021 ◽  
Vol 29 ◽  
pp. 115884
Author(s):  
Yuying Li ◽  
Kaixiang Zhou ◽  
Wentao Guo ◽  
Mengchao Cui
Keyword(s):  
Amyloid Imaging ◽  
Side Chains ◽  
Imaging Probes ◽  
Β Amyloid

scholarly journals Recent progress in the development of metal complexes as β-amyloid imaging probes in the brain

MedChemComm ◽  
2017 ◽  
Vol 8 (7) ◽  
pp. 1393-1407 ◽  
Author(s):  
Kaihua Chen ◽  
Mengchao Cui
Keyword(s):  
Metal Complexes ◽  
Recent Progress ◽  
Amyloid Imaging ◽  
Imaging Probes ◽  
Amyloid Aβ ◽  
Β Amyloid ◽  
The Brain

In this review, we have focused on the recent progress in metal complexes that are able to bind to β-amyloid (Aβ) species.

Radiolabeled pyridinyl analogues of dibenzylideneacetone as β-amyloid imaging probes

RSC Advances ◽  
2016 ◽  
Vol 6 (50) ◽  
pp. 44646-44654 ◽  
Author(s):  
Xiaomei Cui ◽  
Xiaoyang Zhang ◽  
Cheng Peng ◽  
Jiapei Dai ◽  
Boli Liu ◽  
...  
Keyword(s):  
Amyloid Imaging ◽  
Imaging Probes ◽  
Β Amyloid

In continuation of our investigation of the dibenzylideneacetone scaffold as Aβ imaging probes, a series of derivatives containing pyridine rings with lower lipophilicity was synthesized and evaluated.

2-Arylbenzothiazoles labeled with [CpRe/ 99m Tc(CO) 3 ] and evaluated as β -amyloid imaging probes

2016 ◽  
Vol 124 ◽  
pp. 763-772 ◽  
Author(s):  
Jianhua Jia ◽  
Kaixiang Zhou ◽  
Jiapei Dai ◽  
Boli Liu ◽  
Mengchao Cui
Keyword(s):  
Amyloid Imaging ◽  
Imaging Probes ◽  
Β Amyloid

scholarly journals Feasibility of Amylin Imaging in Pancreatic Islets with β-Amyloid Imaging Probes

2014 ◽  
Vol 4 (1) ◽  
Author(s):  
Masashi Yoshimura ◽  
Masahiro Ono ◽  
Hiroyuki Watanabe ◽  
Hiroyuki Kimura ◽  
Hideo Saji
Keyword(s):  
Pancreatic Islets ◽  
Amyloid Imaging ◽  
Imaging Probes ◽  
Β Amyloid

scholarly journals Structural Analysis Reveals an Amyloid Form of the Human Papillomavirus Type 16 E1∧E4 Protein and Provides a Molecular Basis for Its Accumulation

2008 ◽  
Vol 82 (16) ◽  
pp. 8196-8203 ◽  
Author(s):  
Pauline B. McIntosh ◽  
Stephen R. Martin ◽  
Deborah J. Jackson ◽  
Jameela Khan ◽  
Erin R. Isaacson ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Structural Analysis ◽  
Epithelial Cells ◽  
Molecular Basis ◽  
Hpv Infection ◽  
Fibril Formation ◽  
Amyloid Imaging ◽  
Biopsy Material ◽  
Human Papillomavirus Type 16 ◽  
Imaging Probes

ABSTRACT The abundant human papillomavirus (HPV) type 16 E4 protein exists as two distinct structural forms in differentiating epithelial cells. Monomeric full-length 16E1∧E4 contains a limited tertiary fold constrained by the N and C termini. N-terminal deletions facilitate the assembly of E1∧E4 into amyloid-like fibrils, which bind to thioflavin T. The C-terminal region is highly amyloidogenic, and its deletion abolishes amyloid staining and prevents E1∧E4 accumulation. Amyloid-imaging probes can detect 16E1∧E4 in biopsy material, as well as 18E1∧E4 and 33E1∧E4 in monolayer cells, indicating structural conservation. Our results suggest a role for fibril formation in facilitating the accumulation of E1∧E4 during HPV infection.

Inhibition of abnormal PrP formation by amyloid-imaging probes in vitro

Prions ◽  
2006 ◽  
pp. 265-266
Author(s):  
Kensuke Ishikawa ◽  
Yukitsuka Kudo ◽  
Katsumi Doh-ura
Keyword(s):  
Amyloid Imaging ◽  
Imaging Probes

Preclinical characterization of amyloid imaging probes with multiphoton microscopy

2006 ◽  
Vol 9 (s3) ◽  
pp. 401-407 ◽  
Author(s):  
Jesse Skoch ◽  
Bradley T. Hyman ◽  
Brian J. Bacskai
Keyword(s):  
Multiphoton Microscopy ◽  
Amyloid Imaging ◽  
Imaging Probes
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