Bone mass protective potential mediated by bovine milk basic protein requires normal calcium homeostasis in mice

Nutrition ◽  
2021 ◽  
pp. 111409
Author(s):  
Aiko Ono-Ohmachi ◽  
Yuko Ishida ◽  
Yoshikazu Morita ◽  
Ken Kato ◽  
Hitoki Yamanaka ◽  
...  
Keyword(s):  
Bone Mass ◽  
Calcium Homeostasis ◽  
Basic Protein ◽  
Bovine Milk ◽  
Protective Potential ◽  
Milk Basic Protein ◽  
Normal Calcium

scholarly journals Milk Basic Protein Facilitates Increased Bone Mass in Growing Mice

2017 ◽  
Vol 63 (5) ◽  
pp. 315-322 ◽  
Author(s):  
Aiko ONO-OHMACHI ◽  
Yuko ISHIDA ◽  
Yoshikazu MORITA ◽  
Ken KATO ◽  
Takayuki Y. NARA
Keyword(s):  
Bone Mass ◽  
Basic Protein ◽  
Milk Basic Protein

scholarly journals Milk basic protein supplementation exerts an anti-inflammatory effect in a food-allergic enteropathy model mouse

2018 ◽  
Vol 101 (3) ◽  
pp. 1852-1863 ◽  
Author(s):  
Aiko Ono-Ohmachi ◽  
Haruyo Nakajima-Adachi ◽  
Yoshikazu Morita ◽  
Ken Kato ◽  
Satoshi Hachimura
Keyword(s):  
Basic Protein ◽  
Protein Supplementation ◽  
Model Mouse ◽  
Anti Inflammatory ◽  
Milk Basic Protein ◽  
Inflammatory Effect

Milk Basic Protein Promotes Bone Formation and Suppresses Bone Resorption in Healthy Adult Men

2001 ◽  
Vol 65 (6) ◽  
pp. 1353-1357 ◽  
Author(s):  
Yasuhiro TOBA ◽  
Yukihiro TAKADA ◽  
Yasuhiro MATSUOKA ◽  
Yoshikazu MORITA ◽  
Mutsumi MOTOURI ◽  
...  
Keyword(s):  
Bone Resorption ◽  
Bone Formation ◽  
Basic Protein ◽  
Healthy Adult ◽  
Adult Men ◽  
Milk Basic Protein

Milk Basic Protein Increases Bone Mineral Density and Improves Bone Metabolism in Humans

2004 ◽  
pp. 413-429
Author(s):  
Yukihiro Takada ◽  
Seiichiro Aoe ◽  
Yasuhiro Toba ◽  
Kazuhiro Uenishi ◽  
Akira Takeuchi ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Metabolism ◽  
Bone Mineral ◽  
Basic Protein ◽  
Mineral Density ◽  
Milk Basic Protein

Cystatin C in Milk Basic Protein (MBP) and Its Inhibitory Effect on Bone Resorptionin Vitro

2002 ◽  
Vol 66 (12) ◽  
pp. 2531-2536 ◽  
Author(s):  
Yasuhiro MATSUOKA ◽  
Atsushi SERIZAWA ◽  
Tomoe YOSHIOKA ◽  
Jun-ichi YAMAMURA ◽  
Yoshikazu MORITA ◽  
...  
Keyword(s):  
Cystatin C ◽  
Basic Protein ◽  
Inhibitory Effect ◽  
Milk Basic Protein

A new insight into cystatin C contained in milk basic protein to bone metabolism: Effects on osteoclasts and osteoblastic MC3T3-E1 cells in vitro

2018 ◽  
Vol 89 (7) ◽  
pp. 1027-1032 ◽  
Author(s):  
Takehiko Yasueda ◽  
Yusuke Abe ◽  
Mayumi Shiba ◽  
Yoshie Kamo ◽  
Yasuyuki Seto
Keyword(s):  
Bone Metabolism ◽  
Cystatin C ◽  
Basic Protein ◽  
Milk Basic Protein ◽  
Insight Into

Post-parathyroidectomy restoration of normal calcium homeostasis in neonatal primary hyperparathyroidism

1984 ◽  
Vol 105 (3) ◽  
pp. 350-353 ◽  
Author(s):  
J. L. C. Ch'ng ◽  
A. Kaiser ◽  
J. Lynn ◽  
G. F. Joplin
Keyword(s):  
Primary Hyperparathyroidism ◽  
Calcium Homeostasis ◽  
Feedback Inhibition ◽  
Hormone Secretion ◽  
Parathyroid Tissue ◽  
Total Parathyroidectomy ◽  
Total Removal ◽  
Ionic Calcium ◽  
Ectopic Parathyroid ◽  
Normal Calcium

Abstract. Total parathyroidectomy is required to cure neonatal primary hyperparathyroidism (NPH) as any parathyroid remnant quickly becomes hyperplastic, causing recurrent hypercalcaemia. We present a patient with NPH who had total removal of his eutopic parathyroid glands but continued to have parathyroid hormone secretion from presumed ectopic parathyroid tissue. Hypercalcaemia initially recurred but normal calcium homeostasis was established as the child grew older. We postulate that the underlying defect in NPH is decreased sensitivity to the serum ionic calcium feedback inhibition at the parathyroid receptor level and that this sensitivity can improve with age.

Milk basic protein increases ghrelin secretion and bone mineral density in rodents

Nutrition ◽  
2017 ◽  
Vol 39-40 ◽  
pp. 15-19 ◽  
Author(s):  
Yuko Ishida ◽  
Rakhi Chacrabati ◽  
Aiko Ono-Ohmachi ◽  
Zhi Gong ◽  
Chika Ikenoya ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Basic Protein ◽  
Mineral Density ◽  
Ghrelin Secretion ◽  
Milk Basic Protein

scholarly journals Central Neural Regulation of Parathyroid Hormone

2020 ◽  
Author(s):  
L. Zhang ◽  
N. Liu ◽  
J. Shao ◽  
D. Gao ◽  
Y. Liu ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Bone Mass ◽  
Bone Turnover ◽  
Paraventricular Nucleus ◽  
Calcium Homeostasis ◽  
Neural Regulation ◽  
Brain Nuclei ◽  
Trabecular Bone Mass ◽  
Serum Pth ◽  
Stimulation Of

AbstractParathyroid hormone (PTH) is one of the most important hormones responsible for bone turnover and calcium homeostasis, however, the mechanism underlying central neural regulation of PTH in mammals remains largely unknown. In this study, we identified the subfornical organ (SFO) and the paraventricular nucleus (PVN) as two important brain nuclei responded to serum PTH and calcium changes. Using chemogenetics, we found that serum PTH was suppressed by stimulation of SFOGABA neurons followed by a decrease in trabecular bone mass. Conversely, stimulation of SFOVGlut neurons promoted serum PTH and bone mass. The paraventricular nucleus (PVN) is downstream of the SFO, and chemogenetic activation of PVNCaMKII and PVNVGlut neurons induced an increase in serum PTH. These findings reveal important central neural nodes and will advance our understanding of the central neural regulation of PTH at the molecular, cellular and circuit level.

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