Beneficial effect of treadmill exercise during pregnancy of obese mothers against neonatal hypoxia-ischemia in rats

2021 ◽  
pp. 100371
Author(s):  
Elahe Gorgij ◽  
Hamed Fanaei ◽  
Parichehr Yaghmaei ◽  
Mohammad Reza Shahraki ◽  
Hadi Mirahmadi
Keyword(s):  
Beneficial Effect ◽  
Treadmill Exercise ◽  
Neonatal Hypoxia ◽  
Hypoxia Ischemia ◽  
Exercise During Pregnancy

scholarly journals Treadmill Exercise during Pregnancy Decreased Vulnerability to Neonatal Hypoxia-Ischemia through Reducing Inflammation and Increasing Antiapoptotic Gene Expressions and Antioxidant Capacity in Rats

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Elahe Gorgij ◽  
Hamed Fanaei ◽  
Parichehr Yaghmaei ◽  
Mohammad Reza Shahraki ◽  
Hadi Mirahmadi
Keyword(s):  
Antioxidant Capacity ◽  
Treadmill Exercise ◽  
Infarct Volume ◽  
Exercise Group ◽  
Neurological Function ◽  
Bdnf Level ◽  
Gene Expressions ◽  
Tnf Α ◽  
Hypoxia Ischemia ◽  
Exercise During Pregnancy

Background. The purpose of present study was to assess the impact of maternal treadmill exercise during pregnancy on inflammation, oxidative stress, expression of Bax and Bcl-2 genes, and brain-derived neurotrophic factor (BDNF) level in neonatal rat brain after the hypoxia-ischemia injury. Material and Methods. A total of 24 female Wistar rats were utilized in this research. Two groups are randomly considered for rats: (1) not exercised through pregnancy and (2) exercised during pregnancy. Offsprings were divided into four groups including after delivery: (1) sham, (2) sham/exercise (sham/EX), (3) HI, and (4) HI+exercise. HI was induced in pups at postnatal day 8. Neurobehavioral tests were done seven days after HI induction. Then, the brain tissue was taken from the skull to estimate Bcl-2 and Bax gene expressions, BDNF, cerebral edema, infarct volume, inflammatory factors, oxidative stress, and neurological function. Results. The BDNF level in the HI+exercise group was considerably higher than the HI, sham, and sham/EX groups. Tumor necrosis factor (TNF-α), C-reactive protein (CRP), and the whole oxidant capacity (TOC) levels in the HI group were significantly higher than the sham and sham/EX groups. TNF-α, CRP, and TOC levels in the HI+exercise group were significantly lower than the HI group. Total antioxidant capacity (TAC) level in the HI+exercise group was significantly higher than the HI group. Infarct volume and edema percent in the HI+exercise group were significantly lower than the HI group. Neurological function in the HI+exercise group was significantly better than the HI group. Bax expression in the HI+exercise group was significantly lower than the HI group. Bcl-2 expression in the HI+exercise group was significantly higher than the HI group. In the sham group, BDNF, TNF-α, CRP, TAC, TOC, edema levels, and neurological function had no significant difference with the sham/EX group. Conclusion. It appears that the maternal treadmill exercise during pregnancy exerts a supportive impact against neonatal HI brain injury through increasing antioxidant capacity, Bcl-2 expression, and BDNF levels and decreasing inflammation that is resulted in the lower infarct volume and sensorimotor dysfunction.

scholarly journals Activation of autophagy and Akt/CREB signaling play an equivalent role in the neuroprotective effect of rapamycin in neonatal hypoxia-ischemia

Autophagy ◽  
2010 ◽  
Vol 6 (3) ◽  
pp. 366-377 ◽  
Author(s):  
Silvia Carloni ◽  
Silvia Girelli ◽  
Claudia Scopa ◽  
Giuseppe Buonocore ◽  
Mariangela Longini ◽  
...  
Keyword(s):  
Neuroprotective Effect ◽  
Neonatal Hypoxia ◽  
Hypoxia Ischemia

scholarly journals The nonerythropoietic asialoerythropoietin protects against neonatal hypoxia-ischemia as potently as erythropoietin

2004 ◽  
Vol 91 (4) ◽  
pp. 900-910 ◽  
Author(s):  
Xiaoyang Wang ◽  
Changlian Zhu ◽  
Xinhua Wang ◽  
Jens Gammeltoft Gerwien ◽  
Andre Schrattenholz ◽  
...  
Keyword(s):  
Neonatal Hypoxia ◽  
Hypoxia Ischemia

scholarly journals Splenic Immune Cells in Experimental Neonatal Hypoxia–Ischemia

2012 ◽  
Vol 4 (2) ◽  
pp. 208-219 ◽  
Author(s):  
Nancy Fathali ◽  
Robert P. Ostrowski ◽  
Yu Hasegawa ◽  
Tim Lekic ◽  
Jiping Tang ◽  
...  
Keyword(s):  
Immune Cells ◽  
Neonatal Hypoxia ◽  
Hypoxia Ischemia

Neonatal hypoxia-ischemia caused mild motor dysfunction, recovered by acrobatic training, without affecting morphological structures involved in motor control in rats

2019 ◽  
Vol 1707 ◽  
pp. 27-44 ◽  
Author(s):  
Heloísa Deola Confortim ◽  
Bruna Ferrary Deniz ◽  
Wellington de Almeida ◽  
Patrícia Maidana Miguel ◽  
Loise Bronauth ◽  
...  
Keyword(s):  
Motor Control ◽  
Motor Dysfunction ◽  
Neonatal Hypoxia ◽  
Hypoxia Ischemia

Experimental neonatal hypoxia ischemia causes long lasting changes of oxidative stress parameters in the hippocampus and the spleen

2018 ◽  
Vol 46 (4) ◽  
pp. 433-439 ◽  
Author(s):  
Felipe Kawa Odorcyk ◽  
Janaína Kolling ◽  
Eduardo Farias Sanches ◽  
Angela T.S. Wyse ◽  
Carlos Alexandre Netto
Keyword(s):  
Oxidative Stress ◽  
Wistar Rat ◽  
Mortality And Morbidity ◽  
Neonatal Hypoxia ◽  
Oxidative Stress Parameters ◽  
Rat Pups ◽  
Hypoxia Ischemia ◽  
Anti Oxidant ◽  
Enzyme Superoxide Dismutase ◽  
Stress Parameters

Abstract Neonatal hypoxia ischemia (HI) is the main cause of mortality and morbidity in newborns. The mechanisms involved in its progression start immediately and persist for several days. Oxidative stress and inflammation are determinant factors of the severity of the final lesion. The spleen plays a major part in the inflammatory response to HI. This study assessed the temporal progression of HI-induced alterations in oxidative stress parameters in the hippocampus, the most affected brain structure, and in the spleen. HI was induced in Wistar rat pups in post-natal day 7. Production of reactive oxygen species (ROS), and the activity of the anti oxidant enzyme superoxide dismutase and catalase were assessed 24 h, 96 h and 38 days post-HI. Interestingly, both structures showed a similar pattern, with few alterations in the production of ROS species up to 96 h often combined with an increased activity of the anti oxidant enzymes. However, 38 days after the injury, ROS were at the highest in both structures, coupled with a decrease in the activity of the enzymes. Altogether, present results suggest that HI causes long lasting alterations in the hippocampus as well as in the spleen, suggesting a possible target for delayed treatments for HI.

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