scholarly journals The influence of industry sponsorship and conflict of interest on results and conclusions of systematic reviews regarding treatment of knee osteoarthritis

2021 ◽  
Vol 3 (1) ◽  
pp. 100142
Author(s):  
Benjamin Heigle ◽  
Samuel Shepard ◽  
J. Michael Anderson ◽  
Michael Weaver ◽  
Micah Hartwell ◽  
...  
Addiction ◽  
2006 ◽  
Vol 101 (8) ◽  
pp. 1202-1211 ◽  
Author(s):  
Mi-Kyung Hong ◽  
Lisa A. Bero

2020 ◽  
Author(s):  
Jiajie Yu ◽  
Guanyue Su ◽  
Allison Hirst ◽  
Zengyue Yang ◽  
You Zhang ◽  
...  

Abstract Background Conflict of interest (COI) is an important source of bias in research and disclosure is the most frequent strategy to manage COI. Considering the importance of systematic reviews (SRs) and the prevalence of COI is varying among different research fields and the, we conducted a survey to identify the range of conflict of interest in SRs assessing surgical intervention and devices, and explored the association between COI disclosure and conclusion. Methods We retrieved SRs of surgical interventions and devices published in 2017 via PubMed. Information regarding general characteristics, funding source and COI disclosure were extracted. We conducted a descriptive analyses of study characteristics of included systematic reviews. The difference between groups in the authors’ conclusions were compared using the Chi-square test. Results were expressed as odds ratio and its 95% confidence interval. Results 155 SRs were finally identified in 2017, more than half of SRs (58.7%) reported their funding source and 94.2% reported authors’ COI disclosure. Among 146 SRs that stated COI disclosures, only 35 (22.6%) SRs declared at least one author had a COI. More than 40 terms were used to describe COI. Cochrane SRs were more likely to provide a detail description of COI comparing with those in non-CSR (48.0% versus 25.4%, P = 0,023). No association between positive conclusion and COI disclosure was found (P = 0.484, OR = 0.43, 95%CI: 0.08, 2.16). In the subgroup analyses, SRs stating no COI disclosure were more likely to report positive conclusion than those stating at least one type of COI, but the difference is not significantly different (P = 0.406, OR = 1.38, 95%CI: 0.64, 2.98) Conclusion A high rate of COI disclosure without any detailed information. Although little impact of COI disclosure on author’ conclusions in SRs was found for limited sample, clear description of all potential COI is the best way to enhance the credibility of published scholarship and unbiased evidence-informed decision.


2022 ◽  
pp. 1-12
Author(s):  
Mayuree Tangkiatkumjai

This chapter presents an overview of the quantity and quality of clinical research in CAM and publication bias. Descriptive studies and their systematic reviews on CAM, e.g., prevalence and reasons for CAM use, have been widely conducted worldwide. The findings of the efficacy of herbal medicine, traditional Chinese medicine and acupuncture for treating various illnesses, have been highly published. Publications of CAM safety are limited. A number of clinical studies of CAM in treating kidney diseases were lower than other illnesses. Studies of Ayurveda and other CAMs are still lacking. The quality of CAM publications is described based on systematic reviews of assessing CAM publications. Publication bias is explained in terms of selective publications and location bias, language bias and conflict of interest. The mainstream journals are more likely to publish positive findings. Predatory open access and recommendations for assessing predatory journals are addressed in this chapter.


2017 ◽  
Vol 176 (6) ◽  
pp. 1633-1644 ◽  
Author(s):  
F. Gómez-García ◽  
J. Ruano ◽  
M. Aguilar-Luque ◽  
J. Gay-Mimbrera ◽  
B. Maestre-Lopez ◽  
...  

2008 ◽  
Vol 88 (1) ◽  
pp. 123-136 ◽  
Author(s):  
Gro Jamtvedt ◽  
Kristin Thuve Dahm ◽  
Anne Christie ◽  
Rikke H Moe ◽  
Espen Haavardsholm ◽  
...  

Patients with osteoarthritis of the knee are commonly treated by physical therapists. Practice should be informed by updated evidence from systematic reviews. The purpose of this article is to summarize the evidence from systematic reviews on the effectiveness of physical therapy for patients with knee osteoarthritis. Systematic reviews published between 2000 and 2007 were identified by a comprehensive literature search. We graded the quality of evidence across reviews for each comparison and outcome. Twenty-three systematic reviews on physical therapy interventions for patients with knee osteoarthritis were included. There is high-quality evidence that exercise and weight reduction reduce pain and improve physical function in patients with osteoarthritis of the knee. There is moderate-quality evidence that acupuncture, transcutaneous electrical nerve stimulation, and low-level laser therapy reduce pain and that psychoeducational interventions improve psychological outcomes. For other interventions and outcomes, the quality of evidence is low or there is no evidence from systematic reviews.


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