Phase 1 Safety and Immunogenicity Trial of Recombinant Lactococcus lactis Expressing Human Papillomavirus Type 16 E6 Oncoprotein Vaccine

E6 Oncoprotein ◽

Recombinant Lactococcus Lactis

The First Clinical Use of a Recombinant Lactococcus lactis Expressing Human Papillomavirus Type 16 E7 Oncogene Oral Vaccine: A Phase I Safety and Immunogenicity Trial in Healthy Women Volunteers

Molecular Cancer Therapeutics ◽

10.1158/1535-7163.mct-19-0375 ◽

2019 ◽

Vol 19 (2) ◽

pp. 717-727 ◽

Cited By ~ 2

Author(s):

Amir Hossein Mohseni ◽

Sedigheh Taghinezhad-S ◽

Hossein Keyvani

Keyword(s):

Human Papillomavirus ◽

Phase I ◽

Lactococcus Lactis ◽

Oral Vaccine ◽

Clinical Use ◽

Healthy Women ◽

Women Volunteers ◽

Recombinant Lactococcus Lactis ◽

E7 Oncogene

Protection against human papillomavirus type 16-induced tumors in C57BL/6 mice by mucosal vaccination with Lactococcus lactis NZ9000 expressing E6 oncoprotein

Microbial Pathogenesis ◽

10.1016/j.micpath.2018.10.043 ◽

2019 ◽

Vol 126 ◽

pp. 149-156 ◽

Cited By ~ 8

Author(s):

Sedigheh Taghinezhad-S ◽

Amir Hossein Mohseni ◽

Hossein Keyvani ◽

Vadood Razavilar

Keyword(s):

Human Papillomavirus ◽

Lactococcus Lactis ◽

Mucosal Vaccination ◽

E6 Oncoprotein ◽

Induced Tumors

Cervical Cancers Require the Continuous Expression of the Human Papillomavirus Type 16 E7 Oncoprotein Even in the Presence of the Viral E6 Oncoprotein

Cancer Research ◽

10.1158/0008-5472.can-11-3085 ◽

2012 ◽

Vol 72 (16) ◽

pp. 4008-4016 ◽

Cited By ~ 31

Author(s):

Sean F. Jabbar ◽

Soyeong Park ◽

Johannes Schweizer ◽

Marthe Berard-Bergery ◽

Henry C. Pitot ◽

...

Keyword(s):

Human Papillomavirus ◽

Cervical Cancers ◽

E7 Oncoprotein ◽

Subcellular localization and quantitation of the human papillomavirus type 16 E6 oncoprotein through immunocytochemistry detection

Virology ◽

10.1016/j.virol.2012.09.032 ◽

2013 ◽

Vol 435 (2) ◽

pp. 425-432 ◽

Cited By ~ 13

Author(s):

Robert Jackson ◽

Melissa Togtema ◽

Ingeborg Zehbe

Keyword(s):

Human Papillomavirus ◽

Subcellular Localization ◽

Potential Drugs Against Cervical Cancer: Zinc-Ejecting Inhibitors of the Human Papillomavirus Type 16 E6 Oncoprotein

JNCI Journal of the National Cancer Institute ◽

10.1093/jnci/91.14.1211 ◽

1999 ◽

Vol 91 (14) ◽

pp. 1211-1220 ◽

Cited By ~ 46

Author(s):

W. Beerheide ◽

H.-U. Bernard ◽

Y.-J. Tan ◽

A. Ganesan ◽

W. G. Rice ◽

...

Keyword(s):

Cervical Cancer ◽

Human Papillomavirus ◽

Interaction of the human papillomavirus type 16 E6 oncoprotein with wild-type and mutant human p53 proteins.

Journal of Virology ◽

10.1128/jvi.66.8.5100-5105.1992 ◽

1992 ◽

Vol 66 (8) ◽

pp. 5100-5105 ◽

Cited By ~ 86

Author(s):

M Scheffner ◽

T Takahashi ◽

J M Huibregtse ◽

J D Minna ◽

P M Howley

Keyword(s):

Human Papillomavirus ◽

Wild Type ◽

Overexpression of human papillomavirus type 16 E6 oncoprotein increased hypoxia-inducible factor (HIF)-1 protein accumulation and vascular endothelial growth factor (VEGF) expression in lung cancer cells A549

Cell Biology International ◽

10.1042/cbi034s052a ◽

2010 ◽

Vol 34 (8) ◽

pp. S52-S52

Author(s):

Xudong Tang ◽

Gang Li ◽

Li He ◽

Qin Zhang ◽

Jingli Shi

Keyword(s):

Lung Cancer ◽

Vascular Endothelial Growth Factor ◽

Human Papillomavirus ◽

Hypoxia Inducible Factor ◽

Protein Accumulation ◽

Vascular Endothelial ◽

Vegf Expression ◽

E6 Oncoprotein ◽

Endothelial Growth Factor

Intracellular Analysis of the Interaction between the Human Papillomavirus Type 16 E6 Oncoprotein and Inhibitory Peptides

PLoS ONE ◽

10.1371/journal.pone.0132339 ◽

2015 ◽

Vol 10 (7) ◽

pp. e0132339 ◽

Cited By ~ 11

Author(s):

Christina Stutz ◽

Eileen Reinz ◽

Anja Honegger ◽

Julia Bulkescher ◽

Johannes Schweizer ◽

...

Keyword(s):

Human Papillomavirus ◽

Inhibitory Peptides ◽

E6 Oncoprotein ◽

Intracellular Analysis

Targetting of the N-terminal domain of the human papillomavirus type 16 E6 oncoprotein with monomeric scFvs blocks the E6-mediated degradation of cellular p53

Journal of Molecular Recognition ◽

10.1002/(sici)1099-1352(199903/04)12:2<141::aid-jmr453>3.0.co;2-o ◽

1999 ◽

Vol 12 (2) ◽

pp. 141-152 ◽

Cited By ~ 32

Author(s):

Christine Giovane ◽

Gilles Travé ◽

Amélie Briones ◽

Yves Lutz ◽

Bohdan Wasylyk ◽

...

Keyword(s):

Human Papillomavirus ◽

Terminal Domain ◽

Post-Translational Control of IL-1β via the Human Papillomavirus Type 16 E6 Oncoprotein: A Novel Mechanism of Innate Immune Escape Mediated by the E3-Ubiquitin Ligase E6-AP and p53

PLoS Pathogens ◽

10.1371/journal.ppat.1003536 ◽

2013 ◽

Vol 9 (8) ◽

pp. e1003536 ◽

Cited By ~ 72

Author(s):

Martina Niebler ◽

Xu Qian ◽

Daniela Höfler ◽

Vlada Kogosov ◽

Jittranan Kaewprag ◽

...

Keyword(s):

Human Papillomavirus ◽

Ubiquitin Ligase ◽

Translational Control ◽

Immune Escape ◽

E3 Ubiquitin Ligase ◽

Innate Immune ◽