Combination of the Fatty Acid Synthase Inhibitor Orlistat with Cisplatin or Paclitaxel: Effects on Metastatic Tongue Squamous Cell Carcinoma Cells

2015 ◽  
Vol 119 (3) ◽  
pp. e109
Author(s):  
Luciana Yamamoto Almeida ◽  
Fernanda Santos Moreira ◽  
Guilherme Augusto Silva Santos ◽  
Estêvão Azevedo Melo ◽  
Flávia Sammartino Mariano ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Fatty Acid ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Fatty Acid Synthase ◽  
Carcinoma Cells ◽  
Tongue Squamous Cell Carcinoma ◽  
Synthase Inhibitor

Combined Treatment of Metastatic Oral Tongue Squamous Cell Carcinoma Cells With the Fatty Acid Synthase Inhibitor Orlistat and Cisplatin or 5-Fluorouracil

2015 ◽  
Vol 120 (2) ◽  
pp. e106
Author(s):  
LUCIANA YAMAMOTO DE ALMEIDA ◽  
FERNANDA DOS SANTOS MOREIRA ◽  
ESTEVÃO AZEVEDO MELO ◽  
FLÁVIA SAMMARTINO MARIANO ◽  
ULISSES RIBALDO NICOLAU ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Fatty Acid ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Fatty Acid Synthase ◽  
Combined Treatment ◽  
Carcinoma Cells ◽  
Tongue Squamous Cell Carcinoma ◽  
Oral Tongue ◽  
Synthase Inhibitor

Inhibition of Fatty Acid Synthase Synergistically Enhances the Efficacy of Paclitaxel to Induce Apoptosis in Metastatic Tongue Squamous Cell Carcinoma Cells

2015 ◽  
Vol 120 (2) ◽  
pp. e84
Author(s):  
FERNANDA DOS SANTOS MOREIRA ◽  
LUCIANA YAMAMOTO DE ALMEIDA ◽  
ESTEVÃO DE AZEVEDO MELO ◽  
FLAVIA SAMMARTINO MARIANO ◽  
ULISSES RIBALDO NICOLAU ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Fatty Acid ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Fatty Acid Synthase ◽  
Carcinoma Cells ◽  
Tongue Squamous Cell Carcinoma

Isoliquiritigenin Inhibits Proliferation and Induces Apoptosis in Tongue Squamous Cell Carcinoma by Modulating miR-21/FOXG1 Pathway

2019 ◽  
Vol 17 (4) ◽  
pp. 463-469
Author(s):  
Hou Deqiang ◽  
Gao Yufeng ◽  
Bai Ning ◽  
Dong Yu
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Carcinoma Cells ◽  
Tongue Squamous Cell Carcinoma ◽  
Luciferase Assay ◽  
Forkhead Box ◽  
Proliferation And Apoptosis ◽  
Mrna And Protein Expression ◽  
Induced Apoptosis

Isoliquiritigenin is a flavonoid commonly found in liquorice and has been identified as a potent anti-tumor agent. The aim of this study was to investigate whether isoliquiritigenin regulates the proliferation and apoptosis of tongue squamous cell carcinoma cells by regulating forkhead box G1 expression via miR-21. MTT assay and flow cytometry were used to analyze cell proliferation and apoptosis, respectively. Quantitative real time polymerase chain reaction and western blotting were used to detect mRNA and protein expression levels, respectively. The relationship between miR-21 and forkhead box G1 was detected by dual luciferase assay. Isoliquiritigenin inhibited proliferation and induced apoptosis of tongue squamous cell carcinoma cells, and decreased miR-21 levels and promoted forkhead box G1 expression. Forkhead box G1 was then identified as a target of miR-21 and ISL could promote forkhead box G1 expression by inhibiting miR-21. Further analysis suggested that upregulation of miR-21 improved proliferation and suppressed apoptosis of tongue squamous cell carcinoma cells by inhibiting forkhead box G1 expression. Finally, our results revealed that isoliquiritigenin inhibited proliferation and induced apoptosis of tongue squamous cell carcinoma cells by regulating miR-21. Isoliquiritigenin might act as a novel therapeutic treatment for tongue squamous cell carcinoma cells through up-regulation of forkhead box G1 expression via inhibiting miR-21expression.

scholarly journals FHL1 inhibits the growth of tongue squamous cell carcinoma cells via G1/S cell cycle arrest

2015 ◽  
Vol 12 (3) ◽  
pp. 3958-3964 ◽  
Author(s):  
WEI REN ◽  
PANFENG LIAN ◽  
LONG CHENG ◽  
PEIYUN DU ◽  
XIN GUAN ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Cell Cycle Arrest ◽  
Squamous Cell ◽  
Carcinoma Cells ◽  
Tongue Squamous Cell Carcinoma ◽  
Cycle Arrest
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