IMPACT OF EXCISION MARGIN STATUS ON SURVIVAL OF ORAL SQUAMOUS CELL CARCINOMA

BACKGROUND A key technique that is used by the pathologists during intraoperative consultation is frozen section evaluation. It is very important for the surgeons to know if the surgical margin is clear of malignant cells and the status of dysplasia during oncosurgery. There should be concordance between the frozen section margin and paraffin-embedded section. The purpose of the study was to evaluate and validate the accuracy of frozen section surgical margin status in oral squamous cell carcinoma (OSCC) among 2 observers. METHODS A total of 25 histologically diagnosed OSCC cases from April 2018 to April 2019 were included in the study. A total of 122 surgical margin slides (61 frozen sections and paraffin-embedded slides) were retrieved. The interobserver agreement of frozen section margin status with paraffin-embedded was analyzed. RESULTS Interobserver agreement in frozen section margin was 73.80 % with a kappa value of 0.048 (slight) and P-value 0.344. The interobserver agreement for paraffinembedded margin was 93.40 % with a kappa value of 0.572 (moderate) and P-value 0.005. The concordance between frozen and paraffin section by observer 1 was 85.20 % and by observer 2 was 95.10 %. CONCLUSIONS The rate of discordant will get reduced by accurate sampling along with better communication between pathologist and surgeon and at times of uncertainty, a second pathologist’s opinion can be considered for re-evaluating the interpretations. KEY WORDS Frozen Section Margin Status, Interobserver, Paraffin Embedded Margin Status, OSCC

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From molecular diagnostics to molecular targeted therapy with natural product small molecule inhibitors in oral squamous cell carcinoma

Planta Medica ◽

10.1055/s-2007-986722 ◽

2007 ◽

Vol 73 (09) ◽

Cited By ~ 1

Author(s):

VB Konkimalla ◽

VL Suhas ◽

NR Chandra ◽

E Gebhart ◽

T Efferth

Keyword(s):

Squamous Cell Carcinoma ◽

Targeted Therapy ◽

Oral Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Natural Product ◽

Molecular Diagnostics ◽

Small Molecule ◽

Squamous Cell ◽

Molecular Targeted Therapy ◽

Small Molecule Inhibitors

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Role of Clinical Palpation in Evaluation of Cervical Lymph Node in Oral Squamous Cell Carcinoma

Update Dental College Journal ◽

10.3329/updcj.v1i2.13978 ◽

2013 ◽

Vol 1 (2) ◽

pp. 02-06

Author(s):

SM Anwar Sadat ◽

Sufia Nasrin Rita ◽

Shoma Banik ◽

Md Nazmul Hasan Khandker ◽

Md Mahfuz Hossain ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Lymph Node ◽

Oral Squamous Cell Carcinoma ◽

Lymph Nodes ◽

Cell Carcinoma ◽

Squamous Cell ◽

Predictive Value ◽

Cervical Lymph Node ◽

Betel Quid ◽

Cervical Lymph Nodes

A cross sectional study of 29 cases of oral squamous cell carcinoma with or without cervical lymph node metastasis was done among Bangladeshi patients from January 2006 to December 2007. Majority of the study subjects (34.5%) belonged to the age group of 40-49 years. 58.6% of the study subjects were male, while remaining 41.4% of them were female. 51.7% of the lesions were located in the alveolar ridge where the other common sites were buccal mucosa (27.6%) and retro molar area (13.8%). Half of the study subjects (51.7%) were habituated to betel quid chewing followed by 37.9% and 10.3% were habituated to smoking and betel quid-smoking respectively. Grade I lesions was most prevalent (75.9%) in the study subjects. Majority of cases presented with Stage IV lesions (55.2%). The sensitivity, specificity, positive predictive value, negative predictive value & accuracy of clinical palpation method for determining metastatic cervical lymph nodes were 93.33%, 64.29%, 73.68%, 90% and 79.3% respectively. Careful and repeated clinical palpation plays important role in evaluation of cervical lymph nodes though several modern techniques may help additionally in the management of oral cancer.DOI: http://dx.doi.org/10.3329/updcj.v1i2.13978 Update Dent. Coll. j. 2011: 1(2): 02-06

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