Primary mucosal melanoma of the head and neck. Comparison of clinical presentation and histopathologic features of oral and sinonasal melanoma

Acrokeratosis paraneoplastica (Bazex syndrome) is a rare paraneoplastic dermatosis associated with internal malignancies. Clinical presentation is characterized by erythematous or violaceous scaly plaques involving the digits, nose, ears, palms, and soles. Nail changes commonly present concurrently with cutaneous manifestations. In this review, we characterize nail changes associated with acrokeratosis paraneoplastica. A total of 48 cases were analyzed. Nail findings were nonspecific, with the most common being nail plate thickening, onycholysis, subungual hyperkeratosis, longitudinal ridging, discoloration, and nail plate loss. In most patients, nail changes involved the majority of fingernails and toenails and most often appeared prior to the diagnosis of malignancy. The most common associated underlying malignancies were squamous cell carcinomas of the head and neck. A diagnosis of acrokeratosis paraneoplastica should be considered in patients with onychodystrophy involving multiple nails with accompanying atypical psoriasiform dermatoses. Screening for internal malignancies may significantly decrease morbidity and mortality for these patients.

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Adjuvant Therapy and Prognosticators of Survival in Head and Neck Mucosal Melanoma

The Laryngoscope ◽

10.1002/lary.29807 ◽

2021 ◽

Author(s):

Arash Abiri ◽

Tyler M. Yasaka ◽

Brandon M. Lehrich ◽

Khodayar Goshtasbi ◽

Peter Papagiannopoulos ◽

...

Keyword(s):

Adjuvant Therapy ◽

Head And Neck ◽

Mucosal Melanoma

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PO-0824: Feasibility and efficacy of radiotherapy in treating recurrent mucosal melanoma of the head and neck

Radiotherapy and Oncology ◽

10.1016/s0167-8140(21)00841-0 ◽

2020 ◽

Vol 152 ◽

pp. S446

Author(s):

D. Dong ◽

S. Li ◽

L. Li ◽

B. Zheng ◽

W. Wang

Keyword(s):

Head And Neck ◽

Mucosal Melanoma

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Mucosal Melanoma of the Head and Neck

The Laryngoscope ◽

10.1288/00005537-199402000-00001 ◽

1994 ◽

Vol 101 (2) ◽

pp. 121???126 ◽

Cited By ~ 11

Author(s):

Steve P. Lee ◽

Kenneth T. Shimizu ◽

Luu M. Tran ◽

Guy Juillard ◽

Thomas C. Calcaterra

Keyword(s):

Head And Neck ◽

Mucosal Melanoma

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R452 – Nasopharyngeal Yolk Sac Tumors: A Rare Pediatric Occurrence

Otolaryngology ◽

10.1016/j.otohns.2008.05.609 ◽

2008 ◽

Vol 139 (2_suppl) ◽

pp. P196-P196 ◽

Cited By ~ 1

Author(s):

Lorraine M Smith ◽

Ryan F Osborne

Keyword(s):

Head And Neck ◽

Clinical Presentation ◽

Yolk Sac ◽

High Dose ◽

Presenting Symptoms ◽

Mild Improvement ◽

Pathologic Features ◽

Yolk Sac Tumors ◽

Infant Girl ◽

High Level

Problem To report the rare occurrence of a yolk sac tumor of the nose and nasopharynx presenting as acute sinusitis and bilateral complete blindness. Methods The clinical presentation, pathologic features, and management of this 2-year-old infant girl is reviewed. We also performed a medical literature search in English using PUBMED and OVID databases. We then analyzed the literature with respect to clinical presentation, manifestations and therapies for other extra-gonadal yolk sac tumors presenting in the head and neck. Results The patient was treated with 4 courses of high dose cis-platinum, etoposide, bleomycin repeated every 3 weeks along with surgery. She had initial mild improvement in visual perception along with shrinkage of her tumor. The yolk sac malignancies of the head and neck are often, large, aggressive lesions on presentation that once treated have a tendency to recur. Conclusion Yolk sac tumors (endodermal sinus tumors) represent 3–5% of pediatric malignancies. They are rare malignancies in the head and neck, of germ cell origin. Successful treatment usually requires a combination of chemotherapy and surgical extirpation followed by postoperative chemotherapy. Significance Recurrent sinusitis and nasal obstruction in children should be evaluated carefully and with a high level of suspicion for rare nasal and nasopharyngeal malignancies. Early diagnosis and prompt treatment may alleviate many of the presenting symptoms and prolong life.

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The Tumor Suppressor p53 in Mucosal Melanoma of the Head and Neck

Genes ◽

10.3390/genes8120384 ◽

2017 ◽

Vol 8 (12) ◽

pp. 384 ◽

Cited By ~ 4

Author(s):

◽

Keyword(s):

Tumor Suppressor ◽

Head And Neck ◽

Mucosal Melanoma ◽

Tumor Suppressor P53

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Adjuvant radiotherapy plus systemic chemotherapy in resected head and neck mucosal melanoma.

Journal of Clinical Oncology ◽

10.1200/jco.2021.39.15_suppl.e18042 ◽

2021 ◽

Vol 39 (15_suppl) ◽

pp. e18042-e18042

Author(s):

Rong Duan ◽

Bixia Tang ◽

Zhihong Chi ◽

Chuanliang Cui ◽

Bin Lian ◽

...

Keyword(s):

Prognostic Factors ◽

Head And Neck ◽

Distant Metastasis ◽

Adjuvant Radiotherapy ◽

Postoperative Radiotherapy ◽

Local Relapse ◽

Mucosal Melanoma ◽

Uicc Stage ◽

Free Survival ◽

Cox Analysis

e18042 Background: The median over survival (OS) of resected head and neck mucosal melanoma (HNMM) is 49.0 months. About 65% of patients experience local recurrence or distant metastasis after surgery. Therefore, adjuvant therapy is critical to improve the poor prognosis. Methods: Data regarding HNMMs with radical surgery (stage III-IVa, AJCC HNMM 8th version) between September 1, 2006 and February 28, 2020 at Peking University Cancer Hospital was collected retrospectively. Postoperative radiotherapy was usually prescribed as GTV 60-70Gy/CTV 60Gy/30f. Patients were divided into four groups by the adjuvant regimens: radiotherapy+chemotherapy (RC), chemotherapy (C), radiotherapy (R) and observation (O). Results: In total, 368 patients were enrolled, including 104 RC,114 C, 53 R, 97 O, respectively. After median follow-up of 63.9 mo (range: 0.9-146.7), the median local relapse-free survival (LRFS) was 10.1 mo (95%CI: 6.7-13.6) in the O group, as compared with 65.9 mo (95%CI: 31.7-100.1, P＜0.001) in the R group, 75.6 mo (95%CI: 50.1-101.0, P＜0.001) in the C group, and 84.6 mo (95%CI: 48.5-120.8, P＜0.001) in the RC group. The median distant metastasis-free survival (DMFS) was 13.7 mo (95%CI: 8.0-19.5) in the O group, 15.3 mo (95%CI: 8.7-21.9, P = 0.898) in the R group, as compared with 25.7 mo (95%CI: 14.6-36.8, P = 0.001) in the C group, 49.3 mo (95%CI: 32.6-66.0, P＜0.001) in the RC group. Estimated OS was 36.4 mo (95%CI: 24.0-48.8) in the O group, as compared with 30.8 mo (95%CI: 23.0-38.6, P = 0.733) in the R group, 40.8 mo (95%CI: 34.8-46.8, P = 0.289) in the C group, 58.2 mp (95%CI: 36.4-79.9, P = 0.002) in the RC group. Primary location, age, gender, UICC staging and adjuvant regimens were included for multivariate Cox analysis. With regard to OS, UICC stage and RC were the prognostic factors. With regard to DMFS, UICC stage, RC and C were the prognostic factors. With regard to LRFS, UICC stage, RC, R, C were the prognostic factors. Conclusions: It is the largest study on the role of adjuvant radiotherapy and chemotherapy on HNMM till now. The results demonstrate that postoperative radiotherapy improves LRFS but has no impact on DMFS, while adjuvant radiotherapy plus chemotherapy prolongs OS. It further validates the clinical practice of UICC stage of HNMM, which might shed lights on the study of the whole mucosal melanoma.

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