Gene mutations and clinical prognosis of mucosal melanoma in different locations of head and neck

Abstract Background: As a highly malignant tumor type, the mucosal type is the second most common pathological subtype in China. In this study, we analyzed the results and clinical data for C-KIT, NRAS, PDGFRA and BRAF genotypes in patients, to explore the characteristics of gene mutation in head and neck mucosal melanoma and the correlation between the four common gene mutation types and prognosis.Methods: C-KIT (exons 9, 11, 13, 17 and 18), NRAS (exons 1 and 2), PDGFRA (exons 12, 14 and 18) and BRAF (exons 11 and 15) were analyzed by PCR amplification and Sanger sequencing in patients. The Chi-squared test, Log rank test and Cox regression model were used to analyze the risk factors. Results: In total, 96 patients were included in the study. 14 (14.58%) patients had the C-KIT mutation, 6 (6.25%) had the BRAF mutation, 23 (23.96%) had the PDGFRA mutation, and 12 (12.50%) had the NRAS mutation. The NRAS mutation (P = 0.037, 95%CI: 1.050–4.572) was an independent factor affecting postoperative distant metastasis. The mutation types of different primary tumor sites were different. The BRAF mutation was more common in the nasopharynx and other sites (P = 0.008), whereas the NRAS mutation was more common in the nasal cavity/sinus (P = 0.043).Conclusion: The specificity of this genotype may have some guiding significance for treatment of patients with head and neck mucosal melanoma, but this study did not find any correlation with survival time, and this needs further analysis with a larger dataset.

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Methyltransferase like 13 mediates the translation of Snail in head and neck squamous cell carcinoma

International Journal of Oral Science ◽

10.1038/s41368-021-00130-8 ◽

2021 ◽

Vol 13 (1) ◽

Author(s):

Xiaochen Wang ◽

Kang Li ◽

Yuehan Wan ◽

Fangfang Chen ◽

Maosheng Cheng ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Head And Neck ◽

Squamous Cell ◽

Neck Squamous Cell Carcinoma ◽

Translation Efficiency ◽

Mechanism Study ◽

Clinical Prognosis ◽

Cellular Phenotypes

AbstractMethyltransferase like 13 (METTL13), a kind of methyltransferase, is implicated in protein binding and synthesis. The upregulation of METTL13 has been reported in a variety of tumors. However, little was known about its potential function in head and neck squamous cell carcinoma (HNSCC) so far. In this study, we found that METTL13 was significantly upregulated in HNSCC at both mRNA and protein level. Increased METTL13 was negatively associated with clinical prognosis. And METTL13 markedly affected HNSCC cellular phenotypes in vivo and vitro. Further mechanism study revealed that METTL13 could regulate EMT signaling pathway by mediating enhancing translation efficiency of Snail, the key transcription factor in EMT, hence regulating the progression of EMT. Furthermore, Snail was verified to mediate METTL13-induced HNSCC cell malignant phenotypes. Altogether, our study had revealed the oncogenic role of METTL13 in HNSCC, and provided a potential therapeutic strategy.

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Adjuvant Therapy and Prognosticators of Survival in Head and Neck Mucosal Melanoma

The Laryngoscope ◽

10.1002/lary.29807 ◽

2021 ◽

Author(s):

Arash Abiri ◽

Tyler M. Yasaka ◽

Brandon M. Lehrich ◽

Khodayar Goshtasbi ◽

Peter Papagiannopoulos ◽

...

Keyword(s):

Adjuvant Therapy ◽

Head And Neck ◽

Mucosal Melanoma

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PO-0824: Feasibility and efficacy of radiotherapy in treating recurrent mucosal melanoma of the head and neck

Radiotherapy and Oncology ◽

10.1016/s0167-8140(21)00841-0 ◽

2020 ◽

Vol 152 ◽

pp. S446

Author(s):

D. Dong ◽

S. Li ◽

L. Li ◽

B. Zheng ◽

W. Wang

Keyword(s):

Head And Neck ◽

Mucosal Melanoma

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Mucosal Melanoma of the Head and Neck

The Laryngoscope ◽

10.1288/00005537-199402000-00001 ◽

1994 ◽

Vol 101 (2) ◽

pp. 121???126 ◽

Cited By ~ 11

Author(s):

Steve P. Lee ◽

Kenneth T. Shimizu ◽

Luu M. Tran ◽

Guy Juillard ◽

Thomas C. Calcaterra

Keyword(s):

Head And Neck ◽

Mucosal Melanoma

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The Tumor Suppressor p53 in Mucosal Melanoma of the Head and Neck

Genes ◽

10.3390/genes8120384 ◽

2017 ◽

Vol 8 (12) ◽

pp. 384 ◽

Cited By ~ 4

Author(s):

◽

Keyword(s):

Tumor Suppressor ◽

Head And Neck ◽

Mucosal Melanoma ◽

Tumor Suppressor P53

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Adjuvant radiotherapy plus systemic chemotherapy in resected head and neck mucosal melanoma.

Journal of Clinical Oncology ◽

10.1200/jco.2021.39.15_suppl.e18042 ◽

2021 ◽

Vol 39 (15_suppl) ◽

pp. e18042-e18042

Author(s):

Rong Duan ◽

Bixia Tang ◽

Zhihong Chi ◽

Chuanliang Cui ◽

Bin Lian ◽

...

Keyword(s):

Prognostic Factors ◽

Head And Neck ◽

Distant Metastasis ◽

Adjuvant Radiotherapy ◽

Postoperative Radiotherapy ◽

Local Relapse ◽

Mucosal Melanoma ◽

Uicc Stage ◽

Free Survival ◽

Cox Analysis

e18042 Background: The median over survival (OS) of resected head and neck mucosal melanoma (HNMM) is 49.0 months. About 65% of patients experience local recurrence or distant metastasis after surgery. Therefore, adjuvant therapy is critical to improve the poor prognosis. Methods: Data regarding HNMMs with radical surgery (stage III-IVa, AJCC HNMM 8th version) between September 1, 2006 and February 28, 2020 at Peking University Cancer Hospital was collected retrospectively. Postoperative radiotherapy was usually prescribed as GTV 60-70Gy/CTV 60Gy/30f. Patients were divided into four groups by the adjuvant regimens: radiotherapy+chemotherapy (RC), chemotherapy (C), radiotherapy (R) and observation (O). Results: In total, 368 patients were enrolled, including 104 RC,114 C, 53 R, 97 O, respectively. After median follow-up of 63.9 mo (range: 0.9-146.7), the median local relapse-free survival (LRFS) was 10.1 mo (95%CI: 6.7-13.6) in the O group, as compared with 65.9 mo (95%CI: 31.7-100.1, P＜0.001) in the R group, 75.6 mo (95%CI: 50.1-101.0, P＜0.001) in the C group, and 84.6 mo (95%CI: 48.5-120.8, P＜0.001) in the RC group. The median distant metastasis-free survival (DMFS) was 13.7 mo (95%CI: 8.0-19.5) in the O group, 15.3 mo (95%CI: 8.7-21.9, P = 0.898) in the R group, as compared with 25.7 mo (95%CI: 14.6-36.8, P = 0.001) in the C group, 49.3 mo (95%CI: 32.6-66.0, P＜0.001) in the RC group. Estimated OS was 36.4 mo (95%CI: 24.0-48.8) in the O group, as compared with 30.8 mo (95%CI: 23.0-38.6, P = 0.733) in the R group, 40.8 mo (95%CI: 34.8-46.8, P = 0.289) in the C group, 58.2 mp (95%CI: 36.4-79.9, P = 0.002) in the RC group. Primary location, age, gender, UICC staging and adjuvant regimens were included for multivariate Cox analysis. With regard to OS, UICC stage and RC were the prognostic factors. With regard to DMFS, UICC stage, RC and C were the prognostic factors. With regard to LRFS, UICC stage, RC, R, C were the prognostic factors. Conclusions: It is the largest study on the role of adjuvant radiotherapy and chemotherapy on HNMM till now. The results demonstrate that postoperative radiotherapy improves LRFS but has no impact on DMFS, while adjuvant radiotherapy plus chemotherapy prolongs OS. It further validates the clinical practice of UICC stage of HNMM, which might shed lights on the study of the whole mucosal melanoma.

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