scholarly journals Salivary endothelin-1 potential for detecting oral cancer in patients with oral lichen planus or oral cancer in remission

Oral Oncology ◽  
2011 ◽  
Vol 47 (12) ◽  
pp. 1122-1126 ◽  
Author(s):  
Yi-Shing Lisa Cheng ◽  
Terry Rees ◽  
Lee Jordan ◽  
Lance Oxford ◽  
John O’Brien ◽  
...  
Keyword(s):  
Oral Cancer ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Endothelin 1 ◽  
Oral Lichen

CD146 expression in oral lichen planus and oral cancer

2019 ◽  
Vol 24 (1) ◽  
pp. 325-332 ◽  
Author(s):  
Sarinthon Pariyawathee ◽  
Ekarat Phattarataratip ◽  
Kobkan Thongprasom
Keyword(s):  
Oral Cancer ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Oral Lichen ◽  
Cd146 Expression

scholarly journals Complete Blood Count as a Diagnostic Marker in Oral Lichen Planus

2020 ◽  
Vol 11 (SPL3) ◽  
pp. 1766-1771
Author(s):  
Indra G ◽  
Maragathavalli G ◽  
Deepika Rajendran
Keyword(s):  
Oral Cancer ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Blood Count ◽  
Diagnostic Marker ◽  
Complete Blood Count ◽  
Precancerous Lesions ◽  
Oral Submucous Fibrosis ◽  
Oral Precancerous Lesions ◽  
Oral Lichen

Oral precancerous lesions and conditions like oral lichen planus, leukoplakia, or oral submucous fibrosis have the potential to develop into oral cancer. Oral cancer accounts for approximately 3 % of all malignancies. Oral lichen planus is a premalignant condition occurring in the oral cavity due to various factors. Blood investigations are routinely done minimally invasive procedures carried out for various diagnostic purposes. The study aims to identify if the complete blood count (CBC) can be used as a pathologic diagnostic marker in an oral premalignant disorder like oral lichen planus. A total of 64 patients (38 female, 26 male) were taken into the study between the period July 2019 - March 2020. Each patient is exposed to blood investigations, and their results are studied. The results of the study show a minimal variation in the blood results. In conclusion, to determine if it can be used as a pathological diagnostic marker in premalignant disorders like oral lichen planus, further studies must be carried out in larger populations.

Detection of hepatitis C virus RNA in oral lichen planus and oral cancer tissues

2000 ◽  
Vol 29 (6) ◽  
pp. 259-266 ◽  
Author(s):  
Yumiko Nagao ◽  
Michio Sata ◽  
Seiji Noguchi ◽  
Tamiko Seno'O ◽  
Moritoshi Kinoshita ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Oral Cancer ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Hepatitis C Virus Rna ◽  
Virus Rna ◽  
Cancer Tissues ◽  
Oral Lichen

Assessment and Comparison of Salivary Survivin Biomarker in Oral Leukoplakia, Oral Lichen Planus, and Oral Cancer: A Comparative Study

2017 ◽  
Vol 8 (2) ◽  
pp. 73-76 ◽  
Author(s):  
Ruchika Garg ◽  
Arvind V Shetti ◽  
Anjana S Bagewadi
Keyword(s):  
Oral Cancer ◽  
Comparative Study ◽  
Malignant Transformation ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Oral Leukoplakia ◽  
Control Group ◽  
Significant Difference ◽  
Potentially Malignant ◽  
Oral Lichen

ABSTRACT Introduction Oral squamous cell carcinoma (OSCC) is the most common malignant tumor of the oral cavity. It is preceded by various potentially malignant conditions like oral leukoplakia and oral lichen planus. Survivin is an inhibitor of apoptosis whose levels have been found increased in oral cancer as well as various potentially malignant conditions. Thus survivin can act as a biomarker and help in early detection of potentially malignant conditions which can prevent its transformation into malignancy. Aim To assess and compare the level of total human salivary survivin in oral leukoplakia, oral lichen planus, oral cancer, and control group. Materials and methods A total of 96 subjects were included in the study, which were further grouped into 24 in each group. The saliva was analyzed for survivin level among all the four groups. Survivin concentration (pg/mL) was studied in relation to clinical data. The results were analyzed using Mann—Whitney U test to derive the statistical difference. Results The average of levels of survivin in control group was 0.199 pg/mL, in oral leukoplakia group 0.312 pg/mL, in oral lichen planus group 0.380 pg/mL, and in oral cancer group 0.430 pg/mL. A comparison of all these groups revealed statistically significant difference among the groups. Conclusion Survivin may not be considered as an independent predictor of the malignant transformation for premalignant lesions but it can be an indicator for an increased risk of malignant transformation. How to cite this article Garg R, Shetti AV, Bagewadi AS. Assessment and Comparison of Salivary Survivin Biomarker in Oral Leukoplakia, Oral Lichen Planus, and Oral Cancer: A Comparative Study. World J Dent 2017;8(2):73-76.

Neutrophil extracellular traps (NETs) formation induced by TGF-β in oral lichen planus – Possible implications for the development of oral cancer

Immunobiology ◽  
2020 ◽  
Vol 225 (2) ◽  
pp. 151901
Author(s):  
Ewa Jablonska ◽  
Marzena Garley ◽  
Arkadiusz Surazynski ◽  
Kamil Grubczak ◽  
Agnieszka Iwaniuk ◽  
...  
Keyword(s):  
Oral Cancer ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Neutrophil Extracellular Traps ◽  
Extracellular Traps ◽  
Oral Lichen

Is oral cancer incidence among patients with oral lichen planus/oral lichenoid lesions underestimated?

2016 ◽  
Vol 46 (2) ◽  
pp. 148-153 ◽  
Author(s):  
M. A. Gonzalez-Moles ◽  
J. A. Gil-Montoya ◽  
I. Ruiz-Avila ◽  
M. Bravo
Keyword(s):  
Oral Cancer ◽  
Lichen Planus ◽  
Cancer Incidence ◽  
Oral Lichen Planus ◽  
Oral Lichenoid Lesions ◽  
Oral Lichen

scholarly journals Expression of HER2/neu in premalignant lesions of oral cavity

2020 ◽  
Author(s):  
Vansh Verma ◽  
Dr. Ashesh Kumar Jha ◽  
Dr. Karsing Patiri ◽  
Dr. Nikhil Arora
Keyword(s):  
Oral Cancer ◽  
Oral Cavity ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Normal Mucosa ◽  
Premalignant Lesions ◽  
Severe Dysplasia ◽  
Positive Contribution ◽  
Cytoplasmic Staining ◽  
Oral Lichen

Context: Molecular alterations in premalignant lesions of oral cavity are not well known, many reports and have found increased HER2 expression to be correlated with poor prognosis in oral cancer. However,literature on expression of HER2 in premalignant lesions is limited and data is conflicting in nature. Overexpression of HER2 in premalignant lesions may denote its positive contribution in malignant transformation of these lesions. Aims: To evaluate the expression of HER2 in premalignant lesions of oral cavity. Settings and Design: In this prospective observational study of 2 months, patients attending OPD at Department of ENT and meeting the inclusion criteria were included. Methods and Material: 23 samples of Leukoplakia and 1 sample of oral lichen planus were stained by routine H&E to confirm clinical diagnosis and assess dysplasia if any, 5 samples of normal mucosa were used as control. Immunohistochemical staining for HER2 was done. ASCO/CAP 2018 guidelines were used for reporting the results. Statistical analysis used: Percentage of lesions expressing cytoplasmic or membranous expression was calculated. Results: 1 sample of Leukoplakia with severe dysplasia expressed focal membranous staining. 20% leukoplakia lesions expressed cytoplasmic staining. Staining was not observed in oral lichen planus and leucoplakia without dysplasia. Conclusions: Membranous expression in Severe dysplasia and higher expression in oral cancer is in concordance with the multistep theory of carcinogenesis. Larger studies are needed if HER2 is to be proposed as a marker for oral premalignant lesions. Significance of cytoplasmic staining in oral premalignant lesions needs to be elucidated.

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