Increased sensitivity to physical activity among individuals with knee osteoarthritis: Relation to pain outcomes, psychological factors, and responses to quantitative sensory testing

Pain ◽  
2014 ◽  
Vol 155 (4) ◽  
pp. 703-711 ◽  
Author(s):  
Timothy H. Wideman ◽  
Patrick H. Finan ◽  
Robert R. Edwards ◽  
Phillip J. Quartana ◽  
Luis F. Buenaver ◽  
...  
Keyword(s):  
Physical Activity ◽  
Knee Osteoarthritis ◽  
Psychological Factors ◽  
Quantitative Sensory Testing ◽  
Sensory Testing ◽  
Pain Outcomes ◽  
Increased Sensitivity

scholarly journals Sex moderates the effects of positive and negative affect on clinical pain in patients with knee osteoarthritis

2017 ◽  
Vol 16 (1) ◽  
pp. 66-73 ◽  
Author(s):  
Traci J. Speed ◽  
Jessica M. Richards ◽  
Patrick H. Finan ◽  
Michael T. Smith
Keyword(s):  
Sex Differences ◽  
Negative Affect ◽  
Knee Osteoarthritis ◽  
Positive Affect ◽  
Central Sensitization ◽  
Quantitative Sensory Testing ◽  
Sensory Testing ◽  
Clinical Pain ◽  
Pain Outcomes ◽  
State Affect

AbstractBackground and aimsSex differences in clinical pain severity and response to experimental pain are commonly reported, with women generally showing greater vulnerability. Affect, including state (a single rating) and stable (average daily ratings over two weeks) positive affect and negative affect has also been found to impact pain sensitivity and severity, and research suggests that affect may modulate pain differentially as a function of sex. The current study aimed to examine sex as a moderator of the relationships between affect and pain-related outcomes among participants with knee osteoarthritis (KOA).MethodsOne hundred and seventy-nine participants (59 men) with KOA completed electronic diaries assessing clinical pain, positive affect, and negative affect. A subset of participants (n = 120) underwent quantitative sensory testing, from which a single index of central sensitization to pain was derived. We used multiple regression models to test for the interactive effects of sex and affect (positive versus negative and stable versus state) on pain-related outcomes. We used mixed effects models to test for the moderating effects of sex on the relationships between state affect and pain over time.ResultsSex differences in affect and pain were identified, with men reporting significantly higher stable positive affect and lower central sensitization to pain indexed by quantitative sensory testing, as well as marginally lower KOA-specific clinical pain compared to women. Moreover, there was an interaction between stable positive affect and sex on KOA-specific clinical pain and average daily non-specific pain ratings. Post hoc analyses revealed that men showed trends towards an inverse relationship between stable positive affect and pain outcomes, while women showed no relationship between positive affect and pain. There was also a significant interaction between sex and stable negative affect and sex on KOA-specific pain such that men showed a significantly stronger positive relationship between stable negative affect and KOA-specific pain than women. Sex did not interact with state affect on pain outcomes.ConclusionsFindings suggest that men may be particularly sensitive to the effects of stable positive affect and negative affect on clinical pain. Future work with larger samples is needed in order to identify potential mechanisms driving the sex-specific effects of affect on pain.ImplicationsThe current study provides novel data that suggesting that the association of positive affect, negative affect, and pain are different in men versus women with KOA. Further understanding of the difference in affective expression between men and women may lead to the development of novel therapeutic interventions and help to identify additional modifiable factors in the prevention and management of pain.

scholarly journals Discordance between pain and radiographic severity in knee osteoarthritis: Findings from quantitative sensory testing of central sensitization

2013 ◽  
Vol 65 (2) ◽  
pp. 363-372 ◽  
Author(s):  
Patrick H. Finan ◽  
Luis F. Buenaver ◽  
Sara C. Bounds ◽  
Shahid Hussain ◽  
Raymond J. Park ◽  
...  
Keyword(s):  
Knee Osteoarthritis ◽  
Central Sensitization ◽  
Quantitative Sensory Testing ◽  
Sensory Testing ◽  
Radiographic Severity

scholarly journals Investigating the Feasibility of a Modified Quantitative Sensory Testing Approach to Profile Sensory Function and Predict Pain Outcomes Following Intrathecal Baclofen Implant Surgery in Cerebral Palsy

Pain Medicine ◽  
2019 ◽  
Vol 21 (1) ◽  
pp. 109-117
Author(s):  
Chantel C Barney ◽  
Alyssa M Merbler ◽  
Donald A Simone ◽  
David Walk ◽  
Frank J Symons
Keyword(s):  
Cerebral Palsy ◽  
Pain Intensity ◽  
Quantitative Sensory Testing ◽  
Intrathecal Baclofen ◽  
Sensory Function ◽  
Sensory Testing ◽  
Pain Outcomes ◽  
Testing Approach ◽  
Behavioral Reactivity ◽  
Sensory Profiles

Abstract Objectives Intrathecal baclofen (ITB) pumps used to manage spasticity in children with cerebral palsy (CP) also improve pain outcomes for some but not all patients. The purpose of this clinical feasibility study was to explore whether a quantitative sensory testing approach could a) be modified and used to subgroup individuals into sensory profiles and b) test whether the profiles were related to postimplant pain outcomes (i.e., pain responsive or pain persistent). Subjects A purposeful clinical sample of nine children with CP (mean age = 12.5 years, male = 56%) and complex communication needs participated. Methods A prospective within-subject design was used to measure proxy-reported pain before and after ITB implant. Pain response status was determined by proxy-reported pain intensity change (>50% change in maximum rated intensity). A modified quantitative sensory testing (mQST) procedure was used to assess behavioral responsivity to an array of calibrated sensory (tactile/acute nociceptive) stimuli before surgery. Results Seven individuals with presurgical pain had mQST differentiated sensory profiles in relation to ITB pain outcomes and relative to the two individuals with no pain. Presurgically, the ITB pain responsive subgroup (N = 3, maximum rated pain intensity decreased >50% after ITB implant) showed increased behavioral reactivity to an acute nociceptive stimulus and cold stimulus, whereas the ITB pain persistent subgroup (N = 4) showed reduced behavioral reactivity to cold and repeated von Frey stimulation relative to the no pain individuals. Conclusion Implications for patient selection criteria and stratification to presurgically identify individuals with CP “at risk” for persistent postprocedure pain are discussed.

scholarly journals Thermal Quantitative Sensory Testing to Predict Postoperative Pain Outcomes Following Gynecologic Surgery

Pain Medicine ◽  
2014 ◽  
Vol 15 (5) ◽  
pp. 857-864 ◽  
Author(s):  
Shireen Ahmad ◽  
Gildasio S. De Oliveira ◽  
Jane M. Bialek ◽  
Robert J. McCarthy
Keyword(s):  
Postoperative Pain ◽  
Quantitative Sensory Testing ◽  
Gynecologic Surgery ◽  
Sensory Testing ◽  
Pain Outcomes

scholarly journals Expanded Distribution of Pain as a Sign of Central Sensitization in Individuals With Symptomatic Knee Osteoarthritis

2016 ◽  
Vol 96 (8) ◽  
pp. 1196-1207 ◽  
Author(s):  
Enrique Lluch Girbés ◽  
Lirios Dueñas ◽  
Marco Barbero ◽  
Deborah Falla ◽  
Isabel A.C. Baert ◽  
...  
Keyword(s):  
Knee Osteoarthritis ◽  
Central Sensitization ◽  
Quantitative Sensory Testing ◽  
Clinical Symptoms ◽  
Sensory Testing ◽  
Knee Oa ◽  
Pressure Pain Thresholds ◽  
Symptomatic Knee Osteoarthritis ◽  
Pain Frequency ◽  
Pain Drawings

AbstractBackgroundExpanded distribution of pain is considered a sign of central sensitization (CS). The relationship between recording of symptoms and CS in people with knee osteoarthritis (OA) has been poorly investigated.ObjectiveThe aim of this study was to examine whether the area of pain assessed using pain drawings relates to CS and clinical symptoms in people with knee OA.DesignThis was a cross-sectional study.MethodsFifty-three people with knee OA scheduled to undergo primary total knee arthroplasty were studied. All participants completed pain drawings using a novel digital device, completed self-administration questionnaires, and were assessed by quantitative sensory testing. Pain frequency maps were generated separately for women and men. Spearman correlation coefficients were computed to reveal possible correlations between the area of pain and quantitative sensory testing and clinical symptoms.ResultsPain frequency maps revealed enlarged areas of pain, especially in women. Enlarged areas of pain were associated with higher knee pain severity (rs=.325, P<.05) and stiffness (rs=.341, P<.05), lower pressure pain thresholds at the knee (rs=−.306, P<.05) and epicondyle (rs=−.308, P<.05), and higher scores with the Central Sensitization Inventory (rs=.456, P<.01). No significant associations were observed between the area of pain and the remaining clinical symptoms and measures of CS.LimitationsFirm conclusions about the predictive role of pain drawings cannot be drawn. Further evaluation of the reliability and validity of pain area extracted from pain drawings in people with knee OA is needed.ConclusionExpanded distribution of pain was correlated with some measures of CS in individuals with knee OA. Pain drawings may constitute an easy way for the early identification of CS in people with knee OA, but further research is needed.

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