scholarly journals Articulatory network reorganization in Parkinson's disease as assessed by multimodal MRI and acoustic measures

2021 ◽  
Vol 84 ◽  
pp. 122-128
Author(s):  
Patricia Klobusiakova ◽  
Jiri Mekyska ◽  
Lubos Brabenec ◽  
Zoltan Galaz ◽  
Vojtech Zvoncak ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Acoustic Measures ◽  
Multimodal Mri

In vivo multimodal (MRI, SPECT) imaging of the 6-OHDA rat model for Parkinson's disease correlated with behavior and histology

2005 ◽  
Vol 25 (1_suppl) ◽  
pp. S392-S392
Author(s):  
Nadja Van Camp ◽  
Koen Van Laere ◽  
Ruth Vreys ◽  
Marleen Verhoye ◽  
Erwin Lauwers ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Rat Model ◽  
Spect Imaging ◽  
Multimodal Mri

scholarly journals Alterations of the nigrostriatal pathway in a 6-OHDA rat model of Parkinson’s disease evaluated with multimodal MRI

PLoS ONE ◽  
2018 ◽  
Vol 13 (9) ◽  
pp. e0202597 ◽  
Author(s):  
Vincent Perlbarg ◽  
Justine Lambert ◽  
Benjamin Butler ◽  
Mehdi Felfli ◽  
Romain Valabrègue ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Rat Model ◽  
Nigrostriatal Pathway ◽  
Multimodal Mri

scholarly journals Erratum to: Substantia nigra in Parkinson’s disease: a multimodal MRI comparison between early and advanced stages of the disease

2014 ◽  
Vol 35 (5) ◽  
pp. 759-759
Author(s):  
Domenico Aquino ◽  
Valeria Contarino ◽  
Alberto Albanese ◽  
Ludovico Minati ◽  
Laura Farina ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Substantia Nigra ◽  
Advanced Stages ◽  
Multimodal Mri

scholarly journals Multimodal MRI Evaluation of the MitoPark Mouse Model of Parkinson’s Disease

PLoS ONE ◽  
2016 ◽  
Vol 11 (3) ◽  
pp. e0151884 ◽  
Author(s):  
Linlin Cong ◽  
Eric R. Muir ◽  
Cang Chen ◽  
Yusheng Qian ◽  
Jingwei Liu ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Mouse Model ◽  
Multimodal Mri ◽  
Mri Evaluation

Effect of Rate Reduction and Increased Loudness on Acoustic Measures of Anticipatory Coarticulation in Multiple Sclerosis and Parkinson's Disease

2005 ◽  
Vol 48 (2) ◽  
pp. 261-277 ◽  
Author(s):  
Kris Tjaden ◽  
Gregory E. Wilding
Keyword(s):  
Multiple Sclerosis ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Speech Production ◽  
Healthy Controls ◽  
Rate Reduction ◽  
Acoustic Measures ◽  
Slow Condition ◽  
Neurologically Normal ◽  
First Moment

The present study compared patterns of anticipatory coarticulation for utterances produced in habitual, loud, and slow conditions by 17 individuals with multiple sclerosis (MS), 12 individuals with Parkinson's disease (PD), and 15 healthy controls. Coarticulation was inferred from vowel F2 frequencies and consonant first-moment coefficients. Rate-related changes in coarticulation differed depending on the particular phonetic events in an utterance. In some instances, the slow condition was associated with stronger anticipatory effects, but in other instances the slow condition was associated with weaker anticipatory effects, relative to other speaking conditions. In contrast, coarticulatory patterns for the loud and habitual conditions typically did not differ. Coarticulatory patterns also tended to be similar among speaker groups within each condition. Finally, when acoustic measures of coarticulation differed among speaking conditions, the direction and magnitude of the effect generally were similar for healthy controls, speakers with MS, and speakers with PD. These results are consistent with studies suggesting mostly preserved patterns of coarticulation for speakers with mild to moderate dysarthria, as well as research indicating only subtle coordination deficits for individuals with dysarthria. The finding that increased loudness had a negligible effect on coarticulation also appears to be at odds with the suggestion that increased loudness stimulates orofacial coordination for speakers with dysarthria, although studies including speakers exhibiting coordination impairments at habitual speaking rates would provide a stronger test of this suggestion. Lastly, the fact that speaking condition similarly affected acoustic measures of anticipatory coarticulation for all speaker groups suggests the feasibility of applying theories and models of speech production for neurologically normal talkers to the study of dysarthria.

scholarly journals Folded concave penalized learning in identifying multimodal MRI marker for Parkinson’s disease

2016 ◽  
Vol 268 ◽  
pp. 1-6 ◽  
Author(s):  
Hongcheng Liu ◽  
Guangwei Du ◽  
Lijun Zhang ◽  
Mechelle M. Lewis ◽  
Xue Wang ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Multimodal Mri

Substantia nigra in Parkinson’s disease: a multimodal MRI comparison between early and advanced stages of the disease

2013 ◽  
Vol 35 (5) ◽  
pp. 753-758 ◽  
Author(s):  
Domenico Aquino ◽  
Valeria Contarino ◽  
Alberto Albanese ◽  
Ludovico Minati ◽  
Laura Farina ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Substantia Nigra ◽  
Advanced Stages ◽  
Multimodal Mri

Voice and Speech Characteristics of Persons With Parkinson’s Disease Pre- and Post-Pallidotomy Surgery

1999 ◽  
Vol 42 (5) ◽  
pp. 1176-1194 ◽  
Author(s):  
Geralyn M. Schulz ◽  
Teri Peterson ◽  
Christine M. Sapienza ◽  
Melvin Greer ◽  
William Friedman
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Motor Function ◽  
Drug Induced ◽  
Acoustic Measures ◽  
Speech Characteristics ◽  
Preliminary Study ◽  
Globus Pallidus Internal ◽  
Acoustic Measure ◽  
Voice And Speech

Pallidotomy surgery, lesioning the globus pallidus internal, has been performed to alleviate Parkinsonian symptoms and drug-induced dyskinesias. Improvements in limb motor function have been reported in recent years following pallidotomy surgery. The purpose of this preliminary study was to determine the effect of pallidotomy surgery on select voice and speech characteristics of 6 patients with Parkinson’s disease. Acoustic measures were analyzed pre-pallidotomy surgery and again at 3 months following surgery. Preliminary findings indicated that all participants demonstrated positive changes in at least one acoustic measure; 2 of the participants consistently demonstrated positive changes in phonatory and articulatory measures, whereas 3 participants did not consistently demonstrate positive changes postsurgery. The results are discussed relative to the differential effects observed across participants.

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