Milling is an important process for tailoring the particle size distribution for enhanced attributes, such as dissolution, content uniformity, tableting, etc., especially for active pharmaceutical ingredients and excipients in pharmaceutical industries. Milling performance of particulate solids depends on the equipment operating conditions (geometry, process conditions and input energy etc.) as well as material properties (particle size, shape, and mechanical properties, such as Young’s modulus, hardness and fracture toughness). In this paper the particle dynamics in a pin mill is analysed using Discrete Element Method (DEM), combined with a novel approach for assessing particle breakability by single particle impact testing. A sensitivity analysis is carried out addressing the effect of the milling conditions (rotational speed and feed particle flow rate), accounting for feed mechanical properties on the breakage behaviour of the particles. Particle collision energy spectra are calculated and shown to have a distribution with the upper tail end being close to the maximum energy associated with the collision with the rings. Breakage is primarily due to collisions with the rings, except for large particles that are comparable in size with the gap between the rings, nipping is also a contributory breakage mechanism.
Validation of Particle Size Segregation of Sintered Ore during Flowing through Laboratory-scale Chute by Discrete Element Method
