Liver mesenchymal neoplasms: something old, something new

Pathology ◽  
2021 ◽  
Author(s):  
Khaled Algashaamy ◽  
Elizabeth A. Montgomery ◽  
Monica Garcia-Buitrago
Keyword(s):  
Mesenchymal Neoplasms

Gastrointestinal Stromal Tumor Presenting as a Recurrent Vaginal Mass

2004 ◽  
Vol 128 (12) ◽  
pp. 1442-1444 ◽  
Author(s):  
Katherine M. Ceballos ◽  
Julie-Ann Francis ◽  
John L. Mazurka
Keyword(s):  
Differential Diagnosis ◽  
Smooth Muscle ◽  
Gastrointestinal Stromal Tumor ◽  
Interstitial Cell ◽  
Smooth Muscle Tumor ◽  
Stromal Tumor ◽  
Mesenchymal Neoplasms ◽  
Smooth Muscle Neoplasm ◽  
Rectal Involvement ◽  
Vaginal Smooth Muscle

Abstract Gastrointestinal stromal tumors are CD117 (c-Kit)–positive mesenchymal neoplasms with histologic and ultrastructural features of the interstitial cell of Cajal. While tumors outside of the gastrointestinal tract have been described, to our knowledge the case we present is the first such case in the vagina. We describe a 75-year-old woman with a recurrent vaginal gastrointestinal stromal tumor without apparent rectal involvement. This tumor was characterized by short intersecting fascicles of spindled cells, focal necrosis, and 12 to 15 mitoses per 50 high-power fields. Immunohistochemistry revealed diffuse cytoplasmic positivity for CD117 (c-Kit), CD34, vimentin, and h-caldesmon. Tumor cells were negative for S100, desmin, actin, and CAM 5.2. The differential diagnosis in this case included a vaginal smooth muscle tumor. While histologically similar to a smooth muscle neoplasm, the immunohistochemical profile ruled out smooth muscle differentiation. Gastrointestinal stromal tumor should be considered in the differential diagnosis of vaginal mesenchymal neoplasms.

scholarly journals Malignant Mesenchymal Renal Tumor: A Rare Case of Primary Renal Fibrosarcoma

2013 ◽  
Vol 3 ◽  
pp. 52 ◽  
Author(s):  
Madanmohan Gupta ◽  
Nandini U. Bahri ◽  
Pankaj Watal ◽  
Shilpa L. Chudasama ◽  
Swetang G. Brahmbhatt ◽  
...  
Keyword(s):  
Rare Case ◽  
Renal Mass ◽  
Renal Tumor ◽  
Abdominal Discomfort ◽  
Renal Neoplasms ◽  
Cross Sectional ◽  
Elderly Female ◽  
Mesenchymal Neoplasms ◽  
Cross Sectional Imaging ◽  
Rare Group

Malignant mesenchymal neoplasms of kidney constitute a rare group of tumors. Primary fibrosarcoma of kidney is an extremely rare subtype of primary malignant mesenchymal renal neoplasms. An elderly female presented with a gradually increasing abdominal lump and mild abdominal discomfort. On cross-sectional imaging, the lesion showed features suggestive of an atypical renal mass not conforming to either ball or bean type growth pattern. The mass was surgically removed and on histopathological and immunohistological investigations diagnosed to be primary renal fibrosarcoma.

Mesenchymal Neoplasms

2013 ◽  
pp. 169-175
Author(s):  
Scott R. Owens ◽  
Henry D. Appelman
Keyword(s):  
Mesenchymal Neoplasms

Solitary Testicular Myofibroma: A Case Report and Review of the Literature

2005 ◽  
Vol 129 (10) ◽  
pp. 1322-1325
Author(s):  
Samson W. Fine ◽  
North J. Davis ◽  
Lawrence E. Lykins ◽  
Elizabeth Montgomery
Keyword(s):  
Case Report ◽  
Soft Tissues ◽  
Smooth Muscle Actin ◽  
Male Infant ◽  
Muscle Actin ◽  
Review Of The Literature ◽  
Infantile Myofibromatosis ◽  
Internal Organs ◽  
Mesenchymal Neoplasms ◽  
Spindle Cells

Abstract Myofibromas are benign mesenchymal neoplasms of myofibroblastic origin. Most present as solitary lesions at any age, but the presentation of multiple lesions in newborns and infants is known as infantile myofibromatosis. Multicentric lesions commonly involve soft tissues and bone and may involve internal organs, where they are associated with an unfavorable prognosis. Solitary lesions involving the viscera are rare. We report a case of a 3-month-old male infant with a left testicular mass detected during an evaluation for suspected torsion. The patient underwent orchiectomy, revealing a nodular mass with grossly evident foci of necrosis. Histologically, the lesion exhibited small fascicles of plump eosinophilic, smooth muscle actin–positive spindle cells, alternating with larger areas of primitive cells with vesicular nuclei and scant cytoplasm arranged around a hemangiopericytoma-like vasculature. To our knowledge, this is the first report of a myofibroma localized within the testis.

Solitary Fibrous Tumor of the Larynx: A Case Report and Review of the Literature

2006 ◽  
Vol 130 (2) ◽  
pp. 213-216 ◽  
Author(s):  
Jorge E. Dotto ◽  
William Ahrens ◽  
David J. Lesnik ◽  
Diane Kowalski ◽  
Clarence Sasaki ◽  
...  
Keyword(s):  
Case Report ◽  
Solitary Fibrous Tumor ◽  
Review Of The Literature ◽  
Solitary Fibrous Tumors ◽  
Subsequent Investigation ◽  
Mesenchymal Neoplasms ◽  
Fibrous Tumor

Abstract Solitary fibrous tumors are relatively rare mesenchymal neoplasms that were originally described as pleural- or peritoneal-based lesions. Although they were considered a form of mesothelioma, subsequent investigation failed to reveal mesothelial differentiation. Characterization of their histologic and immunohistochemical features, as well as identification in a multitude of nonmesothelial-based locations has further served to distinguish these lesions from the more diffuse and aggressive mesothelioma. Reports of solitary fibrous tumor in the larynx are extremely rare. We report a case of solitary fibrous tumor of the larynx in a 38-year-old man.

Aortic tumour

ESC CardioMed ◽  
2018 ◽  
pp. 2619-2621
Author(s):  
Francesca Urgnani ◽  
Vincent Riambau
Keyword(s):  
Nuclear Medicine ◽  
Monoclonal Antibodies ◽  
Treatment Options ◽  
Aortic Occlusion ◽  
Malignant Tumours ◽  
Nuclear Medicine Imaging ◽  
Mesenchymal Neoplasms ◽  
Low Levels ◽  
Poor Outcomes ◽  
Clinical Conditions

Primary malignant tumours of the aorta are extremely rare and aggressive mesenchymal neoplasms. Symptoms can be related to embolization or aortic occlusion. Diagnosis is difficult since they may mimic heterogeneous clinical conditions. The therapeutic management of aortic tumours shows poor outcomes. Improvements in imaging for an earlier and more precise detection of this pathology, as well as better treatment options, are needed. Hopefully, they will come in the future from advances in nuclear medicine imaging systems and treatment with monoclonal antibodies. However, diagnostic and therapeutic improvements are complicated by the low levels of experience on this condition and the reduced available literature, due to the rarity of the pathology.

scholarly journals Malignant Gastrointestinal Stromal Tumour with Metastasis

2015 ◽  
Vol 01 (01) ◽  
pp. 031-033
Author(s):  
Bhushita Lakhar ◽  
Nilesh Guru
Keyword(s):  
Gastrointestinal Stromal Tumors ◽  
Gastrointestinal Stromal Tumour ◽  
Anatomic Site ◽  
Stromal Tumors ◽  
Mesenchymal Neoplasms ◽  
Imaging Characteristics ◽  
The World ◽  
Mitotic Frequency ◽  
Malignant Lesions

AbstractGastrointestinal stromal tumors (GISTs) are the most usual mesenchymal neoplasms of the gastrointestinal tract. Ever since the classification of GIST as an entity distinct from leiomyoma's, leiomyosarcomas, etc., there has been an increased concern in defining their imaging characteristics. It is estimated that approximately 5000-10,000 people are affected per year by this tumor all over the world. Most GISTs are benign (70-80%). However, these tumors have a spectrum ranging from benign to malignant lesions, depending on its anatomic site, tumor size, and mitotic frequency. We report a case of multiple malignant GIST with metastasis into Liver.

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