Sex differences in α-pyrrolidinopentiophenone (α-PVP)-induced taste avoidance, place preference, hyperthermia and locomotor activity in rats

Abstract Rationale Mephedrone is a frequently overused drug of abuse that belongs to the group of novel psychoactive substances. Although its mechanism of action, as well as toxic and psychoactive effects, has been widely studied, the role of different factors that could contribute to the increased vulnerability to mephedrone abuse is still poorly understood. Objectives The aim of the presented study was to assess the impact of several factors (sex differences, social-conditioning, and chronic mild unpredictable stress — CMUS) on the liability to mephedrone-induced reward in Wistar rats. Methods The rewarding effects of mephedrone in male and female rats were assessed using the conditioned place preference (CPP) procedure. Furthermore, the impact of social factor and stress was evaluated in male rats using social-CPP and CMUS-dependent CPP, respectively. Results Mephedrone induced classic-CPP in female (10 mg/kg), as well as in male (10 and 20 mg/kg) rats. However, the impact of mephedrone treatment during social-CPP was highly dose-dependent as the rewarding effects of low dose of mephedrone (5 mg/kg; non-active in classic-CPP) were potentiated when administered during social-conditioning. Interestingly, social-conditioning with a higher dose of 20 mg/kg (that induced classic-CPP) was able to reverse these effects. Finally, CMUS potentiated rewarding effects of a low dose of mephedrone (5 mg/kg) and increased the level of corticosterone in rats’ prefrontal cortex and hippocampus. Conclusions Altogether, the presented results give new insight into possible factors underlying the vulnerability to mephedrone abuse and can serve as a basis for further studies assessing mechanisms underlying observed effects.

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Effects of β-funaltrexamine and naloxonazine on single-trial morphine-conditioned place preference and locomotor activity

Pharmacology Biochemistry and Behavior ◽

10.1016/s0091-3057(02)01049-3 ◽

2003 ◽

Vol 74 (3) ◽

pp. 617-622 ◽

Cited By ~ 9

Author(s):

M.T Bardo ◽

B.J Gehrke ◽

B.E Shortridge ◽

A.S Rauhut

Keyword(s):

Locomotor Activity ◽

Conditioned Place Preference ◽

Place Preference ◽

Single Trial

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Sex differences in anxiety-like behavior and locomotor activity following chronic nicotine exposure in mice

Neuroscience Letters ◽

10.1016/j.neulet.2008.05.023 ◽

2008 ◽

Vol 439 (2) ◽

pp. 187-191 ◽

Cited By ~ 52

Author(s):

Barbara J. Caldarone ◽

Sarah L. King ◽

Marina R. Picciotto

Keyword(s):

Sex Differences ◽

Locomotor Activity ◽

Nicotine Exposure ◽

Chronic Nicotine

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The Effect of Dihydromyricetin, a Natural Flavonoid, on Morphine-induced Conditioned Place Preference and Physical Dependence in Mice

Drug Research ◽

10.1055/a-1206-6757 ◽

2020 ◽

Vol 70 (09) ◽

pp. 410-416

Author(s):

Leila Etemad ◽

Hadi Farkhari ◽

Mohaddeseh Sadat Alavi ◽

Ali Roohbakhsh

Keyword(s):

Locomotor Activity ◽

Animal Models ◽

Conditioned Place Preference ◽

Gabaa Receptors ◽

Physical Dependence ◽

Place Preference ◽

Morphine Dependence ◽

Male Mice ◽

Alcohol Hangover ◽

Withdrawal Signs

Abstract Objective Dihydromyricetin (DHM), a natural flavonoid, is used to reduce alcohol hangover. It has a modulatory role on GABAA receptors with significant effects on seizure and anxiety in animal models. We aimed to evaluate the effect of DHM on morphine conditioned place preference (CPP) and withdrawal sings following morphine dependence using animal models. Methods The effect of DHM (1, 2 and 5 mg/kg, intraperitoneal; ip) on the acquisition and expression of morphine-induced CPP was evaluated in male mice. Administration of morphine for three consecutive days induced physical dependence. The withdrawal signs such as jumping and defecation were precipitated by administration of naloxone (8 mg/kg, ip). The effect of DHM on the development of physical dependence was assessed by injection of DHM before morphine administrations. Results DHM, at the dose of 5 mg/kg, reduced expression of morphine CPP with an increase in the locomotor activity. DHM, at the doses of 2 and 5 mg/kg, also reduced development of morphine CPP. DHM alleviated development of morphine-induced physical dependence at the dose of 1, 2, and 5 mg/kg by decreasing jumping and defecation. Conclusion These results indicated that DHM decreased acquisition and expression of morphine CPP and inhibited development of morphine-induced physical dependence.

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Diverging frequency-modulated 50-kHz vocalization, locomotor activity and conditioned place preference effects in rats given repeated amphetamine treatment

Neuropharmacology ◽

10.1016/j.neuropharm.2014.04.008 ◽

2014 ◽

Vol 83 ◽

pp. 128-136 ◽

Cited By ~ 34

Author(s):

Ewa Taracha ◽

Ewelina Kaniuga ◽

Stanisław J. Chrapusta ◽

Piotr Maciejak ◽

Lech Śliwa ◽

...

Keyword(s):

Locomotor Activity ◽

Conditioned Place Preference ◽

Place Preference ◽

Amphetamine Treatment

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Sex differences in spontaneous locomotor activity and rotational behavior in meadow voles

Physiology & Behavior ◽

10.1016/s0031-9384(98)00111-5 ◽

1998 ◽

Vol 65 (2) ◽

pp. 387-391 ◽

Cited By ~ 5

Author(s):

C Marczinski ◽

T.S Perrot-Sinal ◽

M Kavaliers ◽

K.-P Ossenkopp

Keyword(s):

Sex Differences ◽

Locomotor Activity ◽

Spontaneous Locomotor Activity ◽

Rotational Behavior ◽

Meadow Voles

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Sex differences in pregabalin-seeking like behavior in a conditioned place preference paradigm

Saudi Pharmaceutical Journal ◽

10.1016/j.jsps.2020.11.001 ◽

2020 ◽

Vol 28 (12) ◽

pp. 1749-1755

Author(s):

Hashem O. Alsaab ◽

Ebtehal Altowairqi ◽

Nada Alzahrani ◽

Reem Alzahrani ◽

Fahad S. Alshehri ◽

...

Keyword(s):

Sex Differences ◽

Conditioned Place Preference ◽

Place Preference ◽

Conditioned Place Preference Paradigm

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α-Conotoxin TxID and [S9K]TxID, α3β4 nAChR Antagonists, Attenuate Expression and Reinstatement of Nicotine-Induced Conditioned Place Preference in Mice

Marine Drugs ◽

10.3390/md18120646 ◽

2020 ◽

Vol 18 (12) ◽

pp. 646

Author(s):

Xiaodan Li ◽

Shen You ◽

Jian Xiong ◽

Yamin Qiao ◽

Jinpeng Yu ◽

...

Keyword(s):

Smoking Cessation ◽

Locomotor Activity ◽

Conditioned Place Preference ◽

Addiction Treatment ◽

Nicotine Addiction ◽

Place Preference ◽

Inhibition Activity ◽

Nicotinic Acetylcholine ◽

The World ◽

Superior Effect

Tobacco smoking has become a prominent health problem faced around the world. The α3β4 nicotinic acetylcholine receptor (nAChR) is strongly associated with nicotine reward and withdrawal symptom. α-Conotoxin TxID, cloned from Conus textile, is a strong α3β4 nAChR antagonist, which has weak inhibition activity of α6/α3β4 nAChR. Meanwhile, its analogue [S9K]TxID only inhibits α3β4 nAChR (IC50 = 6.9 nM), and has no inhibitory activity to other nAChRs. The present experiment investigates the effect of α3β4 nAChR antagonists (TxID and [S9K]TxID) on the expression and reinstatement of nicotine-induced conditioned place preference (CPP) and explores the behaviors of acute nicotine in mice. The animal experimental results showed that TxID and [S9K] TxID could inhibit the expression and reinstatement of CPP, respectively. Moreover, both had no effect in acute nicotine experiment and the locomotor activity in mice. Therefore, these findings reveal that the α3β4 nAChR may be a potential target for anti-nicotine addiction treatment. [S9K]TxID, α3β4 nAChR antagonist, exhibit a superior effect for anti-nicotine addiction, which is promising to develop a novel smoking cessation drug.

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