II. Antidepressants and sexual behavior: Acute fluoxetine, but not ketamine, disrupts paced mating behavior in sexually experienced female rats

Background: Aging is associated neuroendocrine changes in women. Animals can be used to model these changes, as well as changes in reproductive behavior. Objective: The current study was designed to characterize mating behavior across age and assess the effects of age and sexual history on mating behavior. Methods: Sexual motivation was assessed using the partner-preference test, in which a female rat is given the choice to interact with a same-sex conspecific or a sexually-vigorous male rat, with which she can mate. Results: Across repeated mating tests (2-12 months of age), female rats spent more time with the male, displayed more solicitation behaviors, were less likely to leave the male after mounts, but visited both stimulus animals less frequently. Comparing a separate group of age-matched, hormoneyoked female rats mated for the first time at 12 months of age to female rats mated for the first time at 2 months of age showed that the 12 month rats visited both stimulus animals less, were less likely to leave the male after mounts, took longer to return to the male after mounts, and displayed fewer solicitation behaviors than their younger counterparts. Relative to middle-aged female rats once they were sexually experienced, 12 month naïve rats spent less time with the male, were more likely to leave the male after mounts, and displayed fewer solicitation behaviors. Furthermore, 12 month naïve rats failed to discriminate between the stimulus animals, visiting both stimulus animals at the same rate unlike 2 month naïve or 12 month experienced rats. Conclusion: Taken together, these results suggest that aging affects some measures of sexual behavior, but most effects of age can be mitigated by regular, repeated mating.

Download Full-text

Increasing 3α,5α-THP following inhibition of neurosteroid biosynthesis in the ventral tegmental area reinstates anti-anxiety, social, and sexual behavior of naturally receptive rats

Reproduction ◽

10.1530/rep-08-0250 ◽

2009 ◽

Vol 137 (1) ◽

pp. 119-128 ◽

Cited By ~ 23

Author(s):

Cheryl A Frye ◽

Jason J Paris ◽

Madeline E Rhodes

Keyword(s):

Sexual Behavior ◽

Social Interaction ◽

Ventral Tegmental Area ◽

Mating Behavior ◽

Elevated Plus Maze ◽

Female Rats ◽

Plus Maze ◽

Ventral Tegmental ◽

Behavior Inhibition ◽

Progesterone Metabolite

The progesterone metabolite and neurosteroid, 5α-pregnan-3α-ol-20-one (3α,5α-THP), has actions in the midbrain ventral tegmental area (VTA) to modulate lordosis, but its effects on other reproductively relevant behaviors are not well understood. Effects on exploration, anxiety, and social behavior resulting from inhibition of 3α,5α-THP formation, as well as 3α,5α-THP enhancement, were investigated in the midbrain VTA. Naturally sexually receptive, female rats (n=8–10/group) received infusions aimed at the midbrain VTA of vehicle, PK11195 (an inhibitor of neurosteroidogenesis), and/or indomethacin (an inhibitor of 3α,5α-THP formation from prohormones), and were subsequently infused with vehicle or FGIN 1-27 (a neurosteroidogenesis enhancer). The rats were then assessed in a behavioral battery that examined exploration (open field), anxiety (elevated plus maze), social (social interaction), and sexual (paced mating) behavior. Inhibition of 3α,5α-THP formation decreased exploratory, anti-anxiety, social, and sexual behavior, as well as midbrain 3α,5α-THP levels. Infusions of FGIN 1-27 following 3α,5α-THP inhibition restored these behaviors and midbrain 3α,5α-THP levels to those commensurate with control rats that had not been administered inhibitors. These findings suggest that 3α,5α-THP formation in the midbrain VTA may influence appetitive, as well as consummatory, aspects of mating behavior.

Download Full-text

The Features of Sexual Behavior of Female Rats with Hyperandrogenia in Pubertal and Postpubertal Periods

International Journal of Physiology and Pathophysiology ◽

10.1615/intjphyspathophys.v6.i1.40 ◽

2015 ◽

Vol 6 (1) ◽

pp. 35-39

Author(s):

Nadiya D. Nosenko ◽

Anna A. Lymareva

Keyword(s):

Sexual Behavior ◽

Female Rats

Download Full-text

A selective androgen receptor modulator with minimal prostate hypertrophic activity enhances lean body mass in male rats and stimulates sexual behavior in female rats

Endocrine ◽

10.1007/s12020-007-9005-2 ◽

2007 ◽

Vol 32 (1) ◽

pp. 41-51 ◽

Cited By ~ 25

Author(s):

George F. Allan ◽

Pamela Tannenbaum ◽

Tifanie Sbriscia ◽

Olivia Linton ◽

Muh-Tsann Lai ◽

...

Keyword(s):

Sexual Behavior ◽

Androgen Receptor ◽

Lean Body Mass ◽

Body Mass ◽

Female Rats ◽

Male Rats ◽

Selective Androgen Receptor Modulator ◽

Receptor Modulator

Download Full-text

EFFECT OF YOHIMBINE ON CLOMIPRAMINE-INDUCED SEXUAL DYSFUNCTION IN MALE RATS

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2017.v10i2.12970 ◽

2017 ◽

Vol 10 (2) ◽

pp. 92

Author(s):

Devangam Sheshadri Shekar

Keyword(s):

Sexual Behavior ◽

Sexual Dysfunction ◽

Histopathological Examination ◽

Red Light ◽

Female Rats ◽

Male Rats ◽

Male Rat ◽

Testicular Damage

Object: The present investigation has been carried out to find out the effect of yohimbine on clomipramine-induced sexual dysfunction in male rats.Methods: The male rats were treated with clomipramine and yohimbine simultaneously for 60 days. During the treatment, all the male rats werechallenged with the female rats which are in estrous phase and their sexual behavior was observed under dim red light. Half of the animals in each group and remaining on 60 day were sacrificed, blood was collected and serum separated. Testis was collected and preserved in 10% formalin forsubsequent histopathological examination. thResults: The study reveals that yohimbine failed to antagonize the clomipramine-induced sexual dysfunction in male rats in all aspects, except thepartial improvement in the sexual behavior.Conclusion: Yohimbine a well-known aphrodisiac failed to antagonize the clomipramine-induced sexual dysfunction in male rats. The decrease intestosterone levels, a decrease in spermatozoa count were continued even in the presence of yohimbine except improvement in the sexual behaviorparameters. Hence, yohimbine could not be a safe antidote against clomipramine-induced sexual dysfunction in male rats.Keywords: Yohimbine, Clomipramine, Testosterone, Male rat sexual competence, Testicular damage.

Download Full-text