Aloe-emodin-mediated antimicrobial photodynamic therapy against multidrug-resistant Acinetobacter baumannii: an in vivo study

2021 ◽  
pp. 102311
Author(s):  
Yang Wang ◽  
Jiao Li ◽  
Songmei Geng ◽  
Xiaopeng Wang ◽  
Zixin Cui ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Acinetobacter Baumannii ◽  
Multidrug Resistant ◽  
In Vivo Study ◽  
Antimicrobial Photodynamic Therapy ◽  
Aloe Emodin

Antimicrobial photodynamic therapy in chronic osteomyelitis induced by Staphylococcus aureus: An in vitro and in vivo study

2012 ◽  
Author(s):  
João Alves dos Reis Júnior ◽  
Patrícia Nascimento de Assis ◽  
Garde^nia Matos Paraguassú ◽  
Isabele Cardoso Vieira de de Castro ◽  
Renan Ferreira Trindade ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Photodynamic Therapy ◽  
Chronic Osteomyelitis ◽  
In Vivo Study ◽  
Antimicrobial Photodynamic Therapy

Antimicrobial Photodynamic Therapy on Drug-resistant Pseudomonas aeruginosa-induced Infection. An In Vivo Study†

2012 ◽  
Vol 88 (3) ◽  
pp. 590-595 ◽  
Author(s):  
Maria C. E. Hashimoto ◽  
Renato A. Prates ◽  
Ilka T. Kato ◽  
Silvia C. Núñez ◽  
Lília C. Courrol ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Photodynamic Therapy ◽  
In Vivo Study ◽  
Antimicrobial Photodynamic Therapy ◽  
Drug Resistant

scholarly journals Antimicrobial Photodynamic Therapy for Methicillin-ResistantStaphylococcus aureusInfection

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Xiu-jun Fu ◽  
Yong Fang ◽  
Min Yao
Keyword(s):  
Photodynamic Therapy ◽  
Multidrug Resistant ◽  
In Vivo Studies ◽  
Resistant Bacteria ◽  
Antimicrobial Photodynamic Therapy ◽  
Multidrug Resistant Bacteria ◽  
Resistant Infection ◽  
Mrsa Infection

Nowadays methicillin-resistantStaphylococcus aureus(MRSA) is one of the most common multidrug resistant bacteria both in hospitals and in the community. In the last two decades, there has been growing concern about the increasing resistance to MRSA of the most potent antibiotic glycopeptides. MRSA infection poses a serious problem for physicians and their patients. Photosensitizer-mediated antimicrobial photodynamic therapy (PDT) appears to be a promising and innovative approach for treating multidrug resistant infection. In spite of encouraging reports of the use of antimicrobial PDT to inactivate MRSA in large in vitro studies, there are only few in vivo studies. Therefore, applying PDT in the clinic for MRSA infection is still a long way off.

scholarly journals Antimicrobial Photodynamic Therapy and Dental Plaque: A Systematic Review of the Literature

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
G. C. Santin ◽  
D. S. B. Oliveira ◽  
R. Galo ◽  
M. C. Borsatto ◽  
S. A. M. Corona
Keyword(s):  
Systematic Review ◽  
Photodynamic Therapy ◽  
Data Extraction ◽  
Antimicrobial Photodynamic Therapy ◽  
Review Of The Literature ◽  
Eligibility Criteria ◽  
Dental Biofilm ◽  
Quality Assessments

Background. The aim of this study was to perform a systematic review of the literature on the efficacy of antimicrobial photodynamic therapy (PDTa) on cariogenic dental biofilm.Types of Studies Reviewed. Studiesin vivo,in vitro, andin situwere included. Articles that did not address PDTa, those that did not involve cariogenic biofilm, those that used microorganisms in the plankton phase, and reviews were excluded. Data extraction and quality assessments were performed independently by two raters using a scale.Results. Two hundred forty articles were retrieved; only seventeen of them met the eligibility criteria and were analyzed in the present review. Considerable variability was found regarding the methodologies and application protocols for antimicrobial PDTa. Two articles reported unfavorable results.Practical Implications. The present systematic review does not allow drawing any concrete conclusions regarding the efficacy of antimicrobial PDTa, although this method seems to be a promising option.

Photodynamic therapy on bacterial reduction in dental caries: in vivo study

2010 ◽  
Author(s):  
Alessandra Baptista ◽  
Renato Araujo Prates ◽  
Ilka Tiemy Kato ◽  
Marcello Magri Amaral ◽  
Anderson Zanardi de Freitas ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Dental Caries ◽  
In Vivo Study ◽  
Bacterial Reduction

In Vivo Study of Biological Effects of Photodynamic Therapy on Cervical Cancer

2005 ◽  
pp. 215
Author(s):  
V. A. Marquez-Lemus ◽  
B. M. Noguez-Juarez ◽  
L. Solano-Rodriguez ◽  
A. J. Perez-Zapata ◽  
O. P. Schneider-Ehrenberg ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Photodynamic Therapy ◽  
Biological Effects ◽  
In Vivo Study

scholarly journals Genome-Scale Metabolic Modeling Reveals Metabolic Alterations of Multidrug-Resistant Acinetobacter baumannii in a Murine Bloodstream Infection Model

2020 ◽  
Vol 8 (11) ◽  
pp. 1793
Author(s):  
Jinxin Zhao ◽  
Yan Zhu ◽  
Jiru Han ◽  
Yu-Wei Lin ◽  
Michael Aichem ◽  
...  
Keyword(s):  
Acinetobacter Baumannii ◽  
Bloodstream Infection ◽  
Post Infection ◽  
Metabolic Modeling ◽  
Nutrient Utilization ◽  
Multidrug Resistant ◽  
Host Environment ◽  
Gene Essentiality ◽  
Genome Scale

Multidrug-resistant (MDR) Acinetobacter baumannii is a critical threat to human health globally. We constructed a genome-scale metabolic model iAB5075 for the hypervirulent, MDR A. baumannii strain AB5075. Predictions of nutrient utilization and gene essentiality were validated using Biolog assay and a transposon mutant library. In vivo transcriptomics data were integrated with iAB5075 to elucidate bacterial metabolic responses to the host environment. iAB5075 contains 1530 metabolites, 2229 reactions, and 1015 genes, and demonstrated high accuracies in predicting nutrient utilization and gene essentiality. At 4 h post-infection, a total of 146 metabolic fluxes were increased and 52 were decreased compared to 2 h post-infection; these included enhanced fluxes through peptidoglycan and lipopolysaccharide biosynthesis, tricarboxylic cycle, gluconeogenesis, nucleotide and fatty acid biosynthesis, and altered fluxes in amino acid metabolism. These flux changes indicate that the induced central metabolism, energy production, and cell membrane biogenesis played key roles in establishing and enhancing A. baumannii bloodstream infection. This study is the first to employ genome-scale metabolic modeling to investigate A. baumannii infection in vivo. Our findings provide important mechanistic insights into the adaption of A. baumannii to the host environment and thus will contribute to the development of new therapeutic agents against this problematic pathogen.

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