Folic acid-modified phthalocyanine-nanozyme loaded liposomes for targeted photodynamic therapy

In photodynamic therapy (PDT), photosensitizers and light are used to cause photochemically induced cell death. The selectivity and the effectiveness of the phototoxicity in cancer can be increased by a specific uptake of the photosensitizer into tumor cells. A promising target for this goal is the folic acid receptor α (FRα), which is overexpressed on the surface of many tumor cells and mediates an endocytotic uptake. Here, we describe a polysaccharide-based nanoparticle system suitable for targeted uptake and its photochemical and photobiological characterization. The photosensitizer 5, 10, 15, 20-tetraphenyl-21H, 23H-porphyrine (TPP) was encapsulated in spermine- and acetal-modified dextran (SpAcDex) nanoparticles and conjugated with folic acid (FA) on the surface [SpAcDex(TPP)-FA]. The particles are successfully taken up by human HeLa-KB cells, and a light-induced cytotoxicity is observable. An excess of free folate as the competitor for the FRα-mediated uptake inhibits the phototoxicity. In conclusion, folate-modified SpAcDex particles are a promising drug delivery system for a tumor cell targeted photodynamic therapy.

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Folic acid and its derivatives for targeted photodynamic therapy of cancer

Russian Chemical Bulletin ◽

10.1007/s11172-017-1973-7 ◽

2017 ◽

Vol 66 (11) ◽

pp. 1982-2008 ◽

Cited By ~ 9

Author(s):

N. V. Suvorov ◽

A. F. Mironov ◽

M. A. Grin

Keyword(s):

Photodynamic Therapy ◽

Folic Acid ◽

Photodynamic Therapy Of Cancer ◽

Targeted Photodynamic Therapy

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The Interest of Folic Acid in Targeted Photodynamic Therapy

Current Medicinal Chemistry ◽

10.2174/0929867322666150729113912 ◽

2015 ◽

Vol 22 (27) ◽

pp. 3185-3207 ◽

Cited By ~ 15

Author(s):

Aurelie Stallivieri ◽

Francis Baros ◽

Gulim Jetpisbayeva ◽

Bauyrzhan Myrzakhmetov ◽

Celine Frochot

Keyword(s):

Photodynamic Therapy ◽

Folic Acid ◽

Targeted Photodynamic Therapy

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Functional titanium dioxide nanoparticle conjugated with phthalocyanine and folic acid as a promising photosensitizer for targeted photodynamic therapy in vitro and in vivo

Journal of Photochemistry and Photobiology B Biology ◽

10.1016/j.jphotobiol.2020.112122 ◽

2021 ◽

pp. 112122

Author(s):

Xinyue Liang ◽

Yonghui Xie ◽

Junxin Wu ◽

Jing Wang ◽

Marijana Petković ◽

...

Keyword(s):

Titanium Dioxide ◽

Photodynamic Therapy ◽

Folic Acid ◽

Titanium Dioxide Nanoparticle ◽

Targeted Photodynamic Therapy

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OFF/ON galvanic replacement reaction for preparing divergent AuAg nano-hollows as a SERS-visualized drug delivery system in targeted photodynamic therapy

RSC Advances ◽

10.1039/c6ra12971d ◽

2016 ◽

Vol 6 (69) ◽

pp. 64494-64498 ◽

Cited By ~ 13

Author(s):

Chih-Chia Huang ◽

Pei-Hua Lin ◽

Chien-Wei Lee

Keyword(s):

Drug Delivery ◽

Photodynamic Therapy ◽

Folic Acid ◽

Proton Exchange ◽

Detection Sensitivity ◽

Galvanic Replacement ◽

Galvanic Replacement Reaction ◽

Replacement Reaction ◽

Photodynamic Therapy Of Cancer ◽

Targeted Photodynamic Therapy

3-D AuAg nano-hollows were fabricated by an anti-galvanic replacement reaction (off), followed by a proton exchange reaction (on). They exhibited superior Raman detection sensitivity for potentially imaging-guided and folic acid-targeted photodynamic therapy of cancer cells.

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