scholarly journals Basal serum cortisol concentration in very low birth weight infants

2019 ◽  
Vol 60 (6) ◽  
pp. 648-653 ◽  
Author(s):  
Ji Hye Hwang ◽  
Byong Sop Lee ◽  
Chae Young Kim ◽  
Euiseok Jung ◽  
Ellen Ai-Rhan Kim ◽  
...  
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Very Low Birth Weight ◽  
Serum Cortisol ◽  
Cortisol Concentration ◽  
Low Birth Weight Infants ◽  
Basal Serum ◽  
Serum Cortisol Concentration

scholarly journals The Pituitary-Adrenal Responses to Exogenous Human Corticotropin-Releasing Hormone in Preterm, Very Low Birth Weight Infants

1997 ◽  
Vol 82 (3) ◽  
pp. 797-799 ◽  
Author(s):  
P. C. Ng ◽  
G. W. K. Wong ◽  
C. W. K. Lam ◽  
C. H. Lee ◽  
M. Y. Wong ◽  
...  
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Very Low Birth Weight ◽  
Mode Of Delivery ◽  
Corticosteroid Treatment ◽  
Serum Cortisol ◽  
Plasma Acth ◽  
Low Birth Weight Infants ◽  
Acth Concentration ◽  
Adrenal Response

Abstract To evaluate the pituitary-adrenal reserve and to standardize the methodology of performing the human CRH (hCRH) stimulation test, we performed the hCRH test on 14 preterm (<32 gestational weeks), very low birth weight infants, who did not receive antenatal or postnatal corticosteroid treatment, on days 7 and 14 of life. Blood samples were obtained 0 (baseline), 15, 30, and 60 min after an iv dose of hCRH (1μ g/kg). The plasma ACTH concentration rose from a basal value of 5.7 ± 0.6 pmol/L (mean ± sem) to 11.9 ± 2.1 pmol/L (P < 0.005), 9.2 ± 1.2 pmol/L (P < 0.005), and 7.7 ± 0.8 pmol/L (P < 0.005) at 15, 30, and 60 min, respectively. The corresponding rises in serum cortisol from a basal concentration of 396 ± 67 nmol/L were 509 ± 71 nmol/L (P< 0.0001), 647 ± 62 nmol/L (P < 0.0001), and 578 ± 60 nmol/L (P < 0.0001). The plasma ACTH concentration consistently peaked early at 15 min, whereas the maximum cortisol response occurred 30 min post-hCRH stimulation. No significant differences were detected between the hCRH tests performed on days 7 and 14 (P > 0.15). Mechanical ventilation, infant gender, and mode of delivery did not significantly influence the hormonal responses (P > 0.25). We have defined in this study the pattern, the magnitude of the pituitary-adrenal response, and the timing of the peak concentrations of plasma ACTH and serum cortisol in relation to a standard iv dose of hCRH. The hCRH test in very low birth weight infants appears to be safe and reproducible, and produces a pituitary-adrenal response comparable to that seen in older children and adults, indicating that pituitary-adrenal function is mature at these early stages of gestation.

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