Host-defense peptides in skin secretions of the tetraploid frog Silurana epitropicalis with potent activity against methicillin-resistant Staphylococcus aureus (MRSA)

Peptides ◽  
2012 ◽  
Vol 37 (1) ◽  
pp. 113-119 ◽  
Author(s):  
J. Michael Conlon ◽  
Milena Mechkarska ◽  
Manju Prajeep ◽  
Agnes Sonnevend ◽  
Laurent Coquet ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Host Defense ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Host Defense Peptides ◽  
Methicillin Resistant ◽  
Skin Secretions ◽  
Defense Peptides

A comparison of host-defense peptides in skin secretions of female Xenopus laevis×Xenopus borealis and X. borealis×X. laevis F1 hybrids

Peptides ◽  
2013 ◽  
Vol 45 ◽  
pp. 1-8 ◽  
Author(s):  
Milena Mechkarska ◽  
Manju Prajeep ◽  
Jérôme Leprince ◽  
Hubert Vaudry ◽  
Mohammed A. Meetani ◽  
...  
Keyword(s):  
Xenopus Laevis ◽  
Host Defense ◽  
F1 Hybrids ◽  
Host Defense Peptides ◽  
Skin Secretions ◽  
Defense Peptides ◽  
Xenopus Borealis

scholarly journals Phenotypic and Genotypic Characteristics of Methicillin-Resistant Staphylococcus aureus (MRSA) Related to Persistent Endovascular Infection

Antibiotics ◽  
2019 ◽  
Vol 8 (2) ◽  
pp. 71 ◽  
Author(s):  
Liang Li ◽  
Michael R. Yeaman ◽  
Arnold S. Bayer ◽  
Yan Q. Xiong
Keyword(s):  
Staphylococcus Aureus ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Specific Mechanism ◽  
Host Defense Peptides ◽  
Methicillin Resistant ◽  
Preventative Measures ◽  
Life Threatening ◽  
Genotypic Characteristics

Persistent methicillin-resistant Staphylococcus aureus (MRSA) bacteremia (PB) represents an important subset of S. aureus infection and correlates with poor clinical outcomes. MRSA isolates from patients with PB differ significantly from those of resolving bacteremia (RB) with regard to several in vitro phenotypic and genotypic profiles. For instance, PB strains exhibit less susceptibility to cationic host defense peptides and vancomycin (VAN) killing under in vivo-like conditions, greater damage to endothelial cells, thicker biofilm formation, altered growth rates, early activation of many global virulence regulons (e.g., sigB, sarA, sae and agr) and higher expression of purine biosynthesis genes (e.g., purF) than RB strains. Importantly, PB strains are significantly more resistant to VAN treatment in experimental infective endocarditis as compared to RB strains, despite similar VAN minimum inhibitory concentrations (MICs) in vitro. Here, we review relevant phenotypic and genotypic characteristics related to the PB outcome. These and future insights may improve our understanding of the specific mechanism(s) contributing to the PB outcome, and aid in the development of novel therapeutic and preventative measures against this life-threatening infection.

Host-defense peptides isolated from the skin secretions of the Northern red-legged frog Rana aurora aurora

2005 ◽  
Vol 29 (1) ◽  
pp. 83-90 ◽  
Author(s):  
J.Michael Conlon ◽  
Agnes Sonnevend ◽  
Carlos Davidson ◽  
Anni Demandt ◽  
Thierry Jouenne
Keyword(s):  
Host Defense ◽  
Host Defense Peptides ◽  
Rana Aurora ◽  
Skin Secretions ◽  
Defense Peptides
Sign in / Sign up

Export Citation Format

Share Document