Relaxation of human placental chorionic plate blood vessels by calcium-activated potassium channel activation

Placenta ◽  
2013 ◽  
Vol 34 (9) ◽  
pp. A64
Author(s):  
Felicity Hey ◽  
Christina E. Hayward ◽  
Mark Wareing
Keyword(s):  
Potassium Channel ◽  
Blood Vessels ◽  
Channel Activation ◽  
Chorionic Plate ◽  
Calcium Activated Potassium Channel

scholarly journals In Vivo Evidence for Nitric Oxide–Mediated Calcium-Activated Potassium-Channel Activation During Human Endotoxemia

Circulation ◽  
2006 ◽  
Vol 114 (5) ◽  
pp. 414-421 ◽  
Author(s):  
Peter Pickkers ◽  
Mirrin J. Dorresteijn ◽  
Martijn P.W.J.M. Bouw; ◽  
Johannes G. van der Hoeven ◽  
Paul Smits
Keyword(s):  
Nitric Oxide ◽  
Potassium Channel ◽  
Channel Activation ◽  
Human Endotoxemia ◽  
Calcium Activated Potassium Channel

Gastrointestinal effects of Ocimum selloi essential oil is mediated by calcium channel blockade and potassium channel activation

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
SDF Souza ◽  
CS Franca ◽  
FV Menezes ◽  
LCB Costa ◽  
ES Niculau ◽  
...  
Keyword(s):  
Essential Oil ◽  
Potassium Channel ◽  
Calcium Channel ◽  
Channel Blockade ◽  
Calcium Channel Blockade ◽  
Channel Activation

New Insights on KCa3.1 Channel Modulation

2020 ◽  
Vol 26 (18) ◽  
pp. 2096-2101
Author(s):  
Giuseppe Manfroni ◽  
Francesco Ragonese ◽  
Lorenzo Monarca ◽  
Andrea Astolfi ◽  
Loretta Mancinelli ◽  
...  
Keyword(s):  
Potassium Channel ◽  
Critical Role ◽  
Calcium Signalling ◽  
Typical Feature ◽  
Open Probability ◽  
Pharmacological Agents ◽  
Channel Modulation ◽  
Calcium Dependent ◽  
Modelling Techniques ◽  
Calcium Activated Potassium Channel

The human intermediate conductance calcium-activated potassium channel, KCa3.1, is involved in several pathophysiological conditions playing a critical role in cell secretory machinery and calcium signalling. The recent cryo-EM analysis provides new insights for understanding the modulation by both endogenous and pharmacological agents. A typical feature of this channel is the low open probability in saturating calcium concentrations and its modulation by potassium channel openers (KCOs), such as benzo imidazolone 1-EBIO, without changing calcium-dependent activation. In this paper, we proposed a model of KCOs action in the modulation of channel activity. The KCa3.1 channel has a very rich pharmacological profile with several classes of molecules that selectively interact with different binding sites of the channel. Among them, benzo imidazolones can be openers (positive modulators such as 1-EBIO, DC-EBIO) or blockers (negative modulators such as NS1619). Through computation modelling techniques, we identified the 1,4-benzothiazin-3-one as a promising scaffold to develop new KCa3.1 channel modulators. Further studies are needed to explore the potential use of 1-4 benzothiazine- 3-one in KCa3.1 modulation and its pharmacological application.

scholarly journals Bradykinin-induced, endothelium-dependent responses in porcine coronary arteries: involvement of potassium channel activation and epoxyeicosatrienoic acids

2005 ◽  
Vol 145 (6) ◽  
pp. 775-784 ◽  
Author(s):  
Arthur H Weston ◽  
Michel Félétou ◽  
Paul M Vanhoutte ◽  
John R Falck ◽  
William B Campbell ◽  
...  
Keyword(s):  
Potassium Channel ◽  
Coronary Arteries ◽  
Epoxyeicosatrienoic Acids ◽  
Channel Activation
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