Maternal circulating SPINT1 is reduced in small-for-gestational age pregnancies at 26 weeks: Growing Up in Singapore Towards health Outcomes (GUSTO) cohort study

ObjectiveTo investigate socioeconomic differences in six perinatal health outcomes in Denmark in the first decade of the 21st century.DesignA population-based cohort study.SettingDanish national registries.ParticipantsA total of 646 829 live born children and 3076 stillborn children (≥22+0 weeks of gestation) born in Denmark from 2000 to 2009. We excluded children with implausible relations between birth weight and gestational age (n=644), children without information on maternal country of origin (n=138) and implausible values of maternal year of birth (n=36).Main outcome measuresWe investigated the following perinatal health outcomes: stillbirth, neonatal and postneonatal mortality, small-for-gestational age, preterm birth grated into moderate preterm, very preterm and extremely preterm, and congenital anomalies registered in the first year of life.ResultsMaternal educational level was inversely associated with all adverse perinatal outcomes. For all examined outcomes, the risk association displayed a clear gradient across the educational levels. The associations remained after adjustment for maternal age, maternal country of origin and maternal year of birth. Compared with mothers with vocational education, mothers with more than 15 years of education had an adjusted risk ratio for stillbirth of 0.64(95% CI 0.56 to 0.72). The corresponding adjusted risk ratios for neonatal mortality, postneonatal mortality, congenital anomalies, moderate preterm birth and small-for-gestational age were, respectively, 0.79(95% CI 0.67 to 0.93), 0.57(95% CI 0.42 to 0.78), 0.87(95% CI 0.83 to 0.91), 0.80(95% CI 0.77 to 0.83) and 0.83(95% CI 0.81 to 0.85).ConclusionSubstantial educational inequalities in perinatal health were still present in Denmark in the first decade of the 21st century.

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Early-Onset Thrombocytopenia in Small-for-Gestational-Age Neonates: A Retrospective Cohort Study

American Journal of Perinatology ◽

10.1055/s-0036-1592382 ◽

2016 ◽

Vol 33 (S 01) ◽

Author(s):

S. Fustolo-Gunnink ◽

R. Vlug ◽

V. Smits-Wintjens ◽

E. Heckman ◽

A. Te Pas ◽

...

Keyword(s):

Cohort Study ◽

Gestational Age ◽

Small For Gestational Age ◽

Retrospective Cohort Study ◽

Early Onset ◽

Retrospective Cohort

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Faculty Opinions recommendation of Effects of gestational age at birth on health outcomes at 3 and 5 years of age: population based cohort study.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.14264188.15777343 ◽

2012 ◽

Author(s):

Mark Sullivan

Keyword(s):

Cohort Study ◽

Health Outcomes ◽

Gestational Age ◽

Population Based ◽

Gestational Age At Birth ◽

Age At Birth

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Better Diet Quality during Pregnancy Is Associated with a Reduced Likelihood of an Infant Born Small for Gestational Age: An Analysis of the Prospective New Hampshire Birth Cohort Study

Journal of Nutrition ◽

10.1093/jn/nxx005 ◽

2018 ◽

Vol 148 (1) ◽

pp. 22-30 ◽

Cited By ~ 19

Author(s):

Jennifer A Emond ◽

Margaret R Karagas ◽

Emily R Baker ◽

Diane Gilbert-Diamond

Keyword(s):

Cohort Study ◽

Birth Cohort ◽

New Hampshire ◽

Diet Quality ◽

Gestational Age ◽

Small For Gestational Age ◽

Birth Cohort Study

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Maternal serum cadmium level during pregnancy and its association with small for gestational age infants: a population-based birth cohort study

Scientific Reports ◽

10.1038/srep22631 ◽

2016 ◽

Vol 6 (1) ◽

Cited By ~ 23

Author(s):

Hua Wang ◽

Lu Liu ◽

Yong-Fang Hu ◽

Jia-Hu Hao ◽

Yuan-Hua Chen ◽

...

Keyword(s):

Cohort Study ◽

Birth Cohort ◽

Gestational Age ◽

Small For Gestational Age ◽

Population Based ◽

Maternal Serum ◽

Birth Cohort Study ◽

Cadmium Level

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126. Sex and growth specific characteristics of small for gestational age neonates: A prospective cohort study

Pregnancy Hypertension ◽

10.1016/j.preghy.2018.08.074 ◽

2018 ◽

Vol 13 ◽

pp. S24-S25

Author(s):

Eva van der Vlugt ◽

Petra Verburg ◽

Shalem Leemaqz ◽

Lesley Mccowan ◽

Lucilla Poston ◽

...

Keyword(s):

Cohort Study ◽

Prospective Cohort Study ◽

Gestational Age ◽

Small For Gestational Age ◽

Prospective Cohort

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Reduced prevalence of small-for-gestational-age and preterm birth for women of low socioeconomic position: a population-based cohort study comparing antenatal midwifery and physician models of care

BMJ Open ◽

10.1136/bmjopen-2018-022220 ◽

2018 ◽

Vol 8 (10) ◽

pp. e022220 ◽

Cited By ~ 8

Author(s):

Daphne N McRae ◽

Patricia A Janssen ◽

Saraswathi Vedam ◽

Maureen Mayhew ◽

Deborah Mpofu ◽

...

Keyword(s):

British Columbia ◽

Cohort Study ◽

Preterm Birth ◽

Gestational Age ◽

Socioeconomic Position ◽

Small For Gestational Age ◽

Models Of Care ◽

Midwifery Care ◽

Low Socioeconomic ◽

Lower Odds

ObjectiveOur aim was to investigate if antenatal midwifery care was associated with lower odds of small-for-gestational-age (SGA) birth, preterm birth (PTB) or low birth weight (LBW) compared with general practitioner (GP) or obstetrician (OB) models of care for women of low socioeconomic position.SettingThis population-level, retrospective cohort study used province-wide maternity, medical billing and demographic data from British Columbia, Canada.ParticipantsOur study included 57 872 pregnant women, with low socioeconomic position, who: were residents of British Columbia, Canada, carried a singleton fetus, had low to moderate medical/obstetric risk, delivered between 2005 and 2012 and received medical insurance premium assistance.Primary and secondary outcome measuresWe report rates, adjusted ORs (aOR), and 95% CIs for the primary outcome, SGA birth (<the 10th percentile), and secondary outcomes, PTB (<37 weeks’ completed gestation) and LBW (<2500 g).ResultsOur sample included 4705 midwifery patients, 45 114 GP patients and 8053 OB patients. Odds of SGA birth were reduced for patients receiving antenatal midwifery versus GP (aOR 0.71, 95% CI 0.62 to 0.82) or OB care (aOR 0.59, 95% CI 0.50 to 0.69). Odds of PTB were lower for antenatal midwifery versus GP (aOR 0.74, 95% CI 0.63 to 0.86) or OB patients (aOR 0.53, 95% CI 0.45 to 0.62). Odds of LBW were reduced for midwifery versus GP (aOR 0.66, 95% CI 0.53 to 0.82) or OB patients (aOR 0.43, 95% CI 0.34 to 0.54).ConclusionAntenatal midwifery care in British Columbia, Canada, was associated with lower odds of SGA birth, PTB and LBW, for women of low socioeconomic position, compared with physician models of care. Results support the development of policy to ensure antenatal midwifery care is available and accessible for women of low socioeconomic position. Future research is needed to determine the underlying mechanisms linking midwifery care to better birth outcomes for women of low socioeconomic position.

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