Antiphospholipid antibodies do not cause retargeting of placental extracellular vesicles in the maternal body

Placenta ◽  
2022 ◽  
Author(s):  
Tsai BW ◽  
Lau S ◽  
Paek S ◽  
Wise M ◽  
Kando I ◽  
...  
Keyword(s):  
Extracellular Vesicles ◽  
Antiphospholipid Antibodies ◽  
Maternal Body

Extracellular Vesicles in the Antiphospholipid Syndrome

2017 ◽  
Vol 44 (05) ◽  
pp. 493-504 ◽  
Author(s):  
Ravi Alluri ◽  
Shruti Chaturvedi ◽  
Keith McCrae
Keyword(s):  
Tissue Factor ◽  
Extracellular Vesicles ◽  
Antiphospholipid Syndrome ◽  
Antiphospholipid Antibodies ◽  
Bioactive Lipids ◽  
Pathogenic Role ◽  
Cellular Activation ◽  
Clinical Events ◽  
Glycoprotein I ◽  
Relationship Of

AbstractAntiphospholipid antibodies (aPL), particularly those directed against β2-glycoprotein I, cause activation of vascular cells (endothelial cells, platelets, monocytes) and release of extracellular vesicles (EVs), which include exosomes and microparticles (MPs). MPs, particularly endothelial MPs, have been most extensively studied in antiphospholipid syndrome (APS). Compared with healthy controls, patients with aPL have significantly higher levels of circulating endothelial and platelet MPs, including MPs expressing immunological and functional tissue factor. Although a consistent relationship of EVs with APS-related thrombosis and obstetric events has not yet been demonstrated, elevated levels of MPs occurring remote from thrombotic events suggest a chronic state of vascular activation in APS. In addition to being a marker of cellular activation, EVs express bioactive lipids, proteins, and nucleic acids, particularly microribonucleic acid (microRNA). EVs may potentially play a pathogenic role in APS by stimulating thrombosis through tissue factor-dependent and independent mechanisms and by promoting vascular activation. Further research is needed to understand these mechanisms and to determine whether EVs may be a useful biomarker to identify patients with aPL at highest risk of clinical events.

Antiphospholipid antibodies affect mitochondrial DNA levels in placental extracellular vesicles: Alarmin(g) for preeclampsia

Placenta ◽  
2015 ◽  
Vol 36 (9) ◽  
pp. A52
Author(s):  
Mancy Tong ◽  
Qi Chen ◽  
Chez Viall ◽  
Joana Desousa ◽  
Michelle Wise ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Extracellular Vesicles ◽  
Antiphospholipid Antibodies

scholarly journals Antiphospholipid antibodies increase the levels of mitochondrial DNA in placental extracellular vesicles: Alarmin-g for preeclampsia

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Mancy Tong ◽  
Caroline Johansson ◽  
Fengyi Xiao ◽  
Peter R. Stone ◽  
Joanna L. James ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Extracellular Vesicles ◽  
Antiphospholipid Antibodies

Elevated release of extracellular vesicles in obese patients with no-alcoholic fatty liver disease (NAFLD)

2016 ◽  
Vol 54 (12) ◽  
pp. 1343-1404
Author(s):  
A Canbazoglu ◽  
O Kucukoglu ◽  
JP Sowa ◽  
G Gerken ◽  
B Giebel ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Extracellular Vesicles ◽  
Fatty Liver Disease ◽  
Obese Patients ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease
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