Poster 59 Moyamoya Disease and Rehabilitation Outcomes: A Case Series

PM&R ◽  
2011 ◽  
Vol 3 ◽  
pp. S197-S197
Author(s):  
Mallikarjuna Nallegowda ◽  
Ziyad Ayyoub ◽  
Murray Brandstater ◽  
Jared Myers ◽  
Jiangnan Wang ◽  
...  
2016 ◽  
Vol 8 (2) ◽  
pp. 113-117
Author(s):  
Lokesh Chauhan ◽  
◽  
K.S. Rana ◽  
Giriraj Singh ◽  
◽  
...  

Blood ◽  
2006 ◽  
Vol 108 (11) ◽  
pp. 1489-1489 ◽  
Author(s):  
Janna M. Journeycake ◽  
Laura E. Brumley

Abstract Thromboembolic complications in children occur at an estimated rate of 5.3 per 10,000 hospitalized children per year. Over the last decade, investigators have determined that underlying medical conditions such as cancer and congenital heart disease (CHD) and the intensive therapies required to manage these conditions are strongly associated with the thromboembolic complications. Recently, we perceived an increase in the incidence of thrombosis in children with Down Syndrome (DS), a chromosomal abnormality which is associated with both CHD and cancer, but there is very little evidence in the medical literature to suggest that it is an independent risk factor for thrombosis. Although, there are case series describing an association of moyamoya disease and DS, only a few case reports describe venous and arterial thrombosis in children with DS, and there is no information about its rate and severity. Therefore, we conducted a retrospective analysis of patients treated at Children’s Medical Center Dallas between January 1, 2000 and November 30, 2005, hypothesizing that thrombosis would be more prevalent in patients with DS (with or without associated co-morbidities) than in children without DS. ICD-9 codes for CHD, DS, cancer, and thromboembolic complications and the CPT codes for the surgical procedures used to correct CHD were used to identify patients of interest. During the study period, the emergency center, ambulatory outpatient areas, and inpatient units saw 729,324 children. Among these, we identified 511 patients with DS (0.07%), 2168 (0.29%) with CHD, and 1182 (0.16%) with cancer. Sixty-one percent (n=311) of the patients with DS also had CHD, and 2.9% (n=15) had cancer. Thrombosis was identified in 398 (5.4 per 10,000 children). The majority (n=220, 55%) developed deep venous thrombosis (DVT), with catheter-related thrombosis (n= 156) being most common. There were 165 (41%) arterial ischemic strokes (AIS), 19 associated with moyamoya disease. Fifteen children with DS developed thrombosis (rate of 293 per 10, 000 children with DS). Among these 15, DVT occurred in 11 (73%) patients and AIS in 5 (33%), 2 with moyamoya. Among the subgroup of patients diagnosed with AIS, DS was not found to be a risk factor for moyamoya disease (OR 5.6, 95% CI 1.05, 30.5, p=0.1). Two patients with DS (13%) had both DVT and AIS. Children diagnosed with DS (OR 57.5, 95% CI 34.2, 96.5, p<0.0001), CHD (OR 129.5, 95% CI 103, 163, p<0.0001), or cancer (OR 57.3, 95% CI 40, 82, p<0.0001) were more likely to develop thrombosis than children without these three diagnoses. Among the children with CHD, having DS did not increase the odds for thrombosis. However, for children with cancer, DS did increase the odds (OR 9.5, 95% CI 2.7, 33.1, p= 0.007). Four of 15 (27%) children with DS did not have cancer or CHD and still had a higher than expected rate of venous and/or arterial thrombosis (OR 60, 95% CI 23, 156, p< 0.0001). In conclusion, the results of this retrospective analysis indicate that DS may be an independent risk factor for thromboembolic disease during childhood. Prospective studies are needed to confirm these findings and explore potential mechanisms.


2020 ◽  
Vol 138 ◽  
pp. e749-e758 ◽  
Author(s):  
Anthony Larson ◽  
Lorenzo Rinaldo ◽  
Waleed Brinjikji ◽  
Fredric Meyer ◽  
Giuseppe Lanzino

2018 ◽  
Vol 33 (14) ◽  
pp. 901-908 ◽  
Author(s):  
Chengjun Wang ◽  
Meng Zhao ◽  
Jia Wang ◽  
Shuo Wang ◽  
Dong Zhang ◽  
...  

The purpose of this study is to investigate the surgical results and long-term outcomes of encephaloduroarteriosynangiosis for moyamoya disease in pediatric patients. We performed a retrospective analysis of 67 pediatric patients with moyamoya disease who underwent encephaloduroarteriosynangiosis in Beijing Tiantan Hospital. The case series included 36 boys and 31 girls. All the patients underwent surgical revascularization, and a total of 93 encephaloduroarteriosynangiosis procedures were performed (41 unilateral, 26 bilateral). The mean follow-up period after surgery was 30 months. During follow-up, ischemic stroke events were detected in 5 patients and the stroke rate for pediatric patients who underwent encephaloduroarteriosynangiosis procedure was 7.1% per patient-years. At the last follow-up, favorable outcomes (modified Rankin Scale score ≤ 2) were observed in 65 cases (97.0%). Our study suggests that long-term surgical outcome of encephaloduroarteriosynangiosis in pediatric moyamoya disease patients is satisfactory, and this technique has a positive impact on the prevention of stroke recurrence.


2015 ◽  
Vol 29 (6) ◽  
pp. 804-810 ◽  
Author(s):  
Ming Wan ◽  
Cong Han ◽  
Peng Xian ◽  
Wei-Zhong Yang ◽  
De-Sheng Li ◽  
...  

2009 ◽  
Vol 26 (4) ◽  
pp. E8 ◽  
Author(s):  
Robert M. Starke ◽  
Ricardo J. Komotar ◽  
E. Sander Connolly

Moyamoya disease is a chronic cerebrovascular occlusive disorder that results in severe morbidity and death. There is much controversy surrounding the optimal treatment for adult patients with the disorder. There have been no randomized trials to assess the efficacy of any single surgical treatment, and existing case series suffer from inadequate power, selection bias, and inherent differences in patient characteristics. In this article the authors review the literature concerning the optimal surgical treatment of adult patients with moyamoya disease.


Sign in / Sign up

Export Citation Format

Share Document