Effects of long-term antidepressant treatment on oxidative status in major depressive disorder: A 24-week follow-up study

2011 ◽  
Vol 35 (5) ◽  
pp. 1284-1290 ◽  
Author(s):  
Vahap Ozan Kotan ◽  
Emre Sarandol ◽  
Emine Kirhan ◽  
Guven Ozkaya ◽  
Selcuk Kirli
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Antidepressant Treatment ◽  
Oxidative Status ◽  
Major Depressive ◽  
Follow Up Study

scholarly journals Maintenance pharmacotherapy for recurrent major depressive disorder: 5-year follow-up study

2008 ◽  
Vol 193 (2) ◽  
pp. 163-164 ◽  
Author(s):  
Irina A. K. Holma ◽  
K. Mikael Holma ◽  
Tarja K. Melartin ◽  
Erkki T. Isometsä
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Maintenance Treatment ◽  
Antidepressant Treatment ◽  
Psychiatric Patients ◽  
Major Depressive ◽  
Good Adherence ◽  
Follow Up Study ◽  
Recurrent Major Depressive Disorder

SummaryPractice guidelines endorse maintenance antidepressant treatment for recurrent major depressive disorder. In the Vantaa Depression Study, we followed 218 psychiatric patients with major depressive disorder for up to 5 years with a life-chart. Of these patients, 86 (39.4%) had more than three lifetime episodes and an indication for maintenance pharmacotherapy. However, of these, only 57% received treatment and only for 16% of the time indicated. Good adherence to pharmacotherapy in the acute phase independently predicted maintenance treatment. The tertiary preventive impact of maintenance treatment may remain limited, as many patients with major depressive disorder either do not receive it, or receive it for too short a period.

Evaluation of psychosocial functioning in the acute treatment term of major depressive disorder: a 16-week multi-centered follow-up study

2021 ◽  
pp. 102883
Author(s):  
Neslihan ALTUNSOY ◽  
Didem SÜCÜLLÜOĞLU DİKİCİ ◽  
Fikret Poyraz ÇÖKMÜŞ ◽  
Hüseyin Murat ÖZKAN ◽  
Kadir AŞÇIBAŞI ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Psychosocial Functioning ◽  
Acute Treatment ◽  
Major Depressive ◽  
Follow Up Study

Increased mitogen-stimulated lymphocyte proliferation is associated with the clinical response in major depressive disorder in women: A follow-up study

2016 ◽  
Vol 239 ◽  
pp. 220-221
Author(s):  
Antti-Pekka Elomaa ◽  
Heimo Viinamäki ◽  
Ilkka T. Harvima ◽  
Heli Koivumaa-Honkanen ◽  
Kirsi Honkalampi ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Clinical Response ◽  
Lymphocyte Proliferation ◽  
Major Depressive ◽  
Follow Up Study

May duration of untreated illness influence the long-term course of major depressive disorder?

2008 ◽  
Vol 23 (2) ◽  
pp. 92-96 ◽  
Author(s):  
A. Carlo Altamura ◽  
Bernardo Dell'Osso ◽  
Serena Vismara ◽  
Emanuela Mundo
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Antidepressant Treatment ◽  
Age At Onset ◽  
Major Depressive ◽  
Chi Square ◽  
Duration Of Untreated Illness ◽  
Course Variables ◽  
Depressive Episodes

AbstractThe aim of this naturalistic study was to investigate the possible influence of the duration of untreated illness (DUI) on the long-term course of Major Depressive Disorder (MDD). One hundred and thirteen patients with recurrent MDD, according to DSM-IV-TR criteria, followed up for 5 years, were selected, interviewed and their clinical charts were reviewed. The DUI was defined as the interval between the onset of the first depressive episode and the first adequate antidepressant treatment. The sample was divided into two groups according to the DUI: one group with a DUI ≤ 12 months (n = 75), and the other with a DUI > 12 months (n = 38). The main demographic and clinical course variables were compared between the two groups using Student's t-tests or chi-square tests. Patients with a longer DUI showed an earlier age at onset (t = 2.82, p = 0.006) and a longer duration of illness (t = 3.20, p = 0.002) compared to patients with a shorter DUI. In addition, the total number of depressive episodes occurring before the first antidepressant treatment was higher in the group with a longer DUI (t = −2.223, p < 0.03). Even though limited by the retrospective nature of the study, these preliminary findings would suggest that a longer DUI may negatively influence the course of MDD. Larger prospective studies are warranted to further investigate the role of the DUI within MDD.

Intrinsic functional connectivity of cortico-basal ganglia-thalamo-cortical circuitry underlying psychomotor retardation in major depressive disorder

2017 ◽  
Vol 41 (S1) ◽  
pp. S328-S328
Author(s):  
Y. Yin ◽  
Y. Yuan ◽  
L. Fan ◽  
C. Xie ◽  
Z. Zhang
Keyword(s):  
Major Depressive Disorder ◽  
Basal Ganglia ◽  
Functional Connectivity ◽  
Depressive Disorder ◽  
Antidepressant Treatment ◽  
Psychomotor Retardation ◽  
Indirect Pathway ◽  
Major Depressive ◽  
Competing Interest

IntroductionPsychomotor retardation (PMR) in depression is analogous to the hypokinesia in Parkinson's disease, which is associated with the unbalanced direct and indirect pathways of cortico-basal ganglia-thalamo-cortical (CBTC) circuitry. This study hypothesized PMR in major depressive disorder (MDD) should be associated with the hyperactivity of CBTC indirect pathways.ObjectivesTo substantiate the hypothesis that the PMR symptom of MDD might attribute to the hyperactivity of the ortico-basal ganglia-thalamo-cortical indirect pathway which could inhibit psychomotor performance.MethodsWe investigated the intrinsic stiato-subthalamic nucleus (STN)-thalamic functional connectivity (FC), three pivotal hubs of the indirect pathway, in 30 MDD patients with PMR (PMR group) and well matched 30 patients without PMR (NPMR group) at baseline, and 11 patients of each group at follow-up who remitted after antidepressant treatment.ResultsThe results showed increased STN-striatum FC of PMR group at baseline and no more discrepancy at follow-up, and significant correlation between PMR severity and thalamo-STN FC.ConclusionsOur findings suggested the increased STN- striatum FC should be considered as a state biomarker to distinguish MDD patients with PMR from patients without PMR at acute period, and thalamo-STN FC could be identified as the predictor of the PMR severity for MDD patients.Disclosure of interestThe authors have not supplied their declaration of competing interest.

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