scholarly journals The impact of sensory neuropathy and inflammation on epithelial wound healing in diabetic corneas

2022 ◽  
pp. 101039
Author(s):  
Fu-shin X. Yu ◽  
Patrick S.Y. Lee ◽  
Lingling Yang ◽  
Nan Gao ◽  
Yangyang Zhang ◽  
...  
Keyword(s):  
Wound Healing ◽  
Sensory Neuropathy ◽  
Epithelial Wound Healing ◽  
The Impact

Management of Deep Spinal Wound Infections Following Instrumentation Surgery with Subfascial Negative Pressure Wound Therapy

2021 ◽  
Author(s):  
Marcus Rickert ◽  
Michael Rauschmann ◽  
Nizar Latif-Richter ◽  
Mohammad Arabmotlagh ◽  
Tamin Rahim ◽  
...  
Keyword(s):  
Risk Factors ◽  
Wound Healing ◽  
Wound Infection ◽  
Spinal Fusion ◽  
Negative Pressure Wound Therapy ◽  
Wound Infections ◽  
Wound Therapy ◽  
Postoperative Wound ◽  
Deep Wound ◽  
The Impact

Abstract Background and Study Aims The treatment of infections following a spine surgery continues to be a challenge. Negative pressure wound therapy (NPWT) has been an effective method in the context of infection therapy, and its use has gained popularity in recent decades. This study aims to analyze the impact of known risk factors for postoperative wound infection on the efficiency and length of NPWT therapy until healing. Patients and Methods We analyzed 50 cases of NPWT treatment for deep wound infection after posterior and posteroanterior spinal fusion from March 2010 to July 2014 retrospectively. We included 32 women and 18 men with a mean age of 69 years (range, 36–87 years). Individual risk factors for postoperative infection, such as age, gender, obesity, diabetes, immunosuppression, duration of surgery, intraoperative blood loss, and previous surgeries, as well as type and onset (early vs. late) of the infection were analyzed. We assessed the associations between these risk factors and the number of revisions until wound healing. Results In 42 patients (84%), bacterial pathogens were successfully detected by means of intraoperative swabs and tissue samples during first revision. A total of 19 different pathogens could be identified with a preponderance of Staphylococcus epidermidis (21.4%) and S. aureus (19.0%). Methicillin-resistant S. aureus (MRSA) was recorded in two patients (2.6%). An average of four NPWT revisions was required until the infection was cured. Patients with infections caused by mixed pathogens required a significantly higher number of revisions (5.3 vs. 3.3; p < 0.01) until definitive wound healing. For the risk factors, no significant differences in the number of revisions could be demonstrated when compared with the patients without the respective risk factor. Conclusion NPWT was an effective therapy for the treatment of wound infections after spinal fusion. All patients in the study had their infections successfully cured, and all spinal implants could be retained. The number of revisions was similar to those reported in the published literature. The present study provides insights regarding the effectiveness of NPWT for the treatment of deep wound infection after spinal fusion. Further investigations on the impact of potential risk factors for postoperative wound healing disorders are required. Better knowledge on the impact of specific risk factors will contribute to a higher effectiveness of prophylaxis for postoperative wound infections considering the patient-specific situation.

Role of the C Domain of IGFs in Synergistic Promotion, with a Substance P–Derived Peptide, of Rabbit Corneal Epithelial Wound Healing

2004 ◽  
Vol 45 (4) ◽  
pp. 1125 ◽  
Author(s):  
Naoyuki Yamada ◽  
Ryoji Yanai ◽  
Masatsugu Nakamura ◽  
Makoto Inui ◽  
Teruo Nishida
Keyword(s):  
Wound Healing ◽  
Substance P ◽  
Corneal Epithelial ◽  
Epithelial Wound Healing

The functions of FoxO transcription factors in epithelial wound healing

2018 ◽  
Vol 60 (2) ◽  
pp. 105-109 ◽  
Author(s):  
Chaoyang Miao ◽  
Yunpeng Li ◽  
Xiaoyan Zhang
Keyword(s):  
Wound Healing ◽  
Transcription Factors ◽  
Epithelial Wound Healing ◽  
Foxo Transcription Factors

Expression of Nerve Growth Factor during Corneal Epithelial Wound Healing in Rats

2011 ◽  
Vol 52 (5) ◽  
pp. 597
Author(s):  
Hye Young Shin ◽  
Ji Wook Yang ◽  
Young Chun Lee ◽  
Su Young Kim
Keyword(s):  
Wound Healing ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Nerve Growth ◽  
Corneal Epithelial ◽  
Epithelial Wound Healing

scholarly journals Transcription factor CUX1 is required for intestinal epithelial wound healing and targets the VAV2-RAC1 Signalling complex

2017 ◽  
Vol 1864 (12) ◽  
pp. 2347-2355 ◽  
Author(s):  
Roxanne Latreille ◽  
Raphaëlle Servant ◽  
Mathieu Darsigny ◽  
Sébastien Marcoux ◽  
Christine Jones ◽  
...  
Keyword(s):  
Wound Healing ◽  
Transcription Factor ◽  
Intestinal Epithelial ◽  
Epithelial Wound Healing
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