Recent advances in the separation and purification of lactic acid from fermentation broth

2021 ◽  
Vol 104 ◽  
pp. 142-151
Author(s):  
Chenglong Li ◽  
Ming Gao ◽  
Wenbin Zhu ◽  
Nuohan Wang ◽  
Xiaoyu Ma ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Fermentation Broth ◽  
Separation And Purification ◽  
Recent Advances

Separation and Purification of Lactic Acid from Fermentation Broth Using Membrane-Integrated Separation Processes

2017 ◽  
Vol 56 (29) ◽  
pp. 8301-8310 ◽  
Author(s):  
Hee Dae Lee ◽  
Min Yong Lee ◽  
Yoon Sung Hwang ◽  
Young Hoon Cho ◽  
Hyo Won Kim ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Fermentation Broth ◽  
Separation And Purification ◽  
Separation Processes

scholarly journals Statistical Optimization of Lactic Acid Extraction Using Green Solvent and Mixed Extractants (TOA and TOMAC)

2020 ◽  
Vol 21 (1) ◽  
pp. 20-35
Author(s):  
Anil Kumar ◽  
Avinash Thakur
Keyword(s):  
Lactic Acid ◽  
Distribution Coefficient ◽  
Process Parameters ◽  
Chemical Engineering ◽  
Fermentation Broth ◽  
Mutual Effect ◽  
Reactive Extraction ◽  
Acid Extraction ◽  
Green Solvent ◽  
Separation And Purification

Since some previous years, reactive extraction has become more attractive and competitive technique for the separation and purification of lower carboxylic acids from fermentation broth as well as from dilute aqueous streams. This paper shows the results of investigation of reactive extraction of lactic acid (LA) from an aqueous solution using the synergistic mixture of the extractants (TOA (tri-n-octylamine) and TOMAC (Tri-n-octylmethylammonium chloride)) and a non-toxic and biocompatible green solvent (soybean oil). Three-level Box-Behnken design (BBD) under response surface methodology (RSM) was opted for the experimental design and to interpret the mutual effect of seven independent process parameters on the LA distribution coefficient (KD). The maximum values of LA distribution coefficient (KD=2.51) and its extraction efficiency (ηη=71.5%) were obtained for the optimum values of various process parameters such as 0.02 [M] initial LA concentration (CC1), 0.5 (v/v) extractant ratio (α), 28.66% (v/v) mixed extractants concentration (ψ), 2 (v/v) phase ratio (φ), 270C temperature (T), 102 rpm stirring speed (ω), and 63 mincontact time (τ). This present investigation will provide a noble discussion on LA reactive extraction using green solvent and on various influencing process parameters for gaining the enhanced value of LA distribution coefficient (KD). Chemical Engineering Research Bulletin 21(2019) 20-35

scholarly journals Study of Lactic Acid Thermal Behavior Using Thermoanalytical Techniques

2017 ◽  
Vol 2017 ◽  
pp. 1-7 ◽  
Author(s):  
Andrea Komesu ◽  
Patricia Fazzio Martins Martinez ◽  
Betânia Hoss Lunelli ◽  
Johnatt Oliveira ◽  
Maria Regina Wolf Maciel ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Thermal Behavior ◽  
Fermentation Broth ◽  
High Reactivity ◽  
Vaporization Enthalpy ◽  
Separation And Purification ◽  
Scanning Calorimetry ◽  
Biotechnological Production ◽  
Separation Processes ◽  
Thermoanalytical Techniques

Actually, there is a growing interest in the biotechnological production of lactic acid by fermentation aiming to substitute fossil fuel routes. The development of an efficient method for its separation and purification from fermentation broth is very important to assure the economic viability of production. Due to its high reactivity and tendency to decompose at high temperatures, the study of lactic acid thermal behavior is essential for its separation processes and potential application. In the present study, differential scanning calorimetry (DSC) analyses showed endothermic peaks related to the process of evaporation. Data of thermogravimetry (TG/DTG) were correlated to Arrhenius and Kissinger equations to provide the evaporation kinetic parameters and used to determine the vaporization enthalpy. Activation energies were 51.08 and 48.37 kJ·mol−1 and frequency values were 859.97 and 968.81 s−1 obtained by Arrhenius and Kissinger equations, respectively. Thermogravimetry, coupled with mass spectroscopy (TG-MS), provided useful information about decomposition products when lactic acid was heated at 573 K for approximately 30 min.

Optimizing and scale-up strategy of molecular distillation for the purification of lactic acid from fermentation broth

2015 ◽  
pp. 150623131312002 ◽  
Author(s):  
Jiang Yu ◽  
Aiwu Zeng ◽  
Xigang Yuan ◽  
Xinyu Zhang ◽  
Ji Ju
Keyword(s):  
Lactic Acid ◽  
Molecular Distillation ◽  
Fermentation Broth ◽  
Scale Up

scholarly journals Chemocatalytic Production of Lactates from Biomass-Derived Sugars

2018 ◽  
Vol 2018 ◽  
pp. 1-18 ◽  
Author(s):  
Heng Zhang ◽  
Yulin Hu ◽  
Liying Qi ◽  
Jian He ◽  
Hu Li ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Heterogeneous Catalysts ◽  
Catalytic Performance ◽  
Green Solvents ◽  
Separation And Purification ◽  
Sustainable Resources ◽  
Base Catalysts ◽  
Heterogeneous Catalytic ◽  
Acid And Base ◽  
Relative Separation

In recent decades, a great deal of attention has been paid to the exploration of alternative and sustainable resources to produce biofuels and valuable chemicals, with aims of reducing the reliance on depleting confined fossil resources and alleviating serious economic and environmental issues. In line with this, lignocellulosic biomass-derived lactic acid (LA, 2-hydroxypropanoic acid), to be identified as an important biomass-derived commodity chemical, has found wide applications in food, pharmaceuticals, and cosmetics. In spite of the current fermentation of saccharides to produce lactic acid, sustainability issues such as environmental impact and high cost derived from the relative separation and purification process will be growing with the increasing demands of necessary orders. Alternatively, chemocatalytic approaches to manufacture LA from biomass (i.e., inedible cellulose) have attracted extensive attention, which may give rise to higher productivity and lower costs related to product work-up. This work presents a review of the state-of-the-art for the production of LA using homogeneous, heterogeneous acid, and base catalysts, from sugars and real biomass like rice straw, respectively. Furthermore, the corresponding bio-based esters lactate which could serve as green solvents, produced from biomass with chemocatalysis, is also discussed. Advantages of heterogeneous catalytic reaction systems are emphasized. Guidance is suggested to improve the catalytic performance of heterogeneous catalysts for the production of LA.

Extraction and separation of D/L-lactic acid in simulated fermentation broth

2011 ◽  
Vol 28 (7) ◽  
pp. 1608-1612 ◽  
Author(s):  
Jun Zhou ◽  
Wentao Bi ◽  
Kyung Ho Row
Keyword(s):  
Lactic Acid ◽  
Fermentation Broth ◽  
Extraction And Separation

Separation and purification of lactic acid: Fundamental studies on the reverse osmosis down-stream process

Desalination ◽  
1995 ◽  
Vol 101 (3) ◽  
pp. 269-277 ◽  
Author(s):  
M.K.H. Liew ◽  
S. Tanaka ◽  
M. Morita
Keyword(s):  
Lactic Acid ◽  
Reverse Osmosis ◽  
Separation And Purification

scholarly journals Application of electrodialysis for lactic acid recovery

2013 ◽  
Vol 19 (No. 2) ◽  
pp. 73-80 ◽  
Author(s):  
V. Hábová ◽  
K. Melzoch ◽  
M. Rychtera ◽  
L. Přibyl ◽  
V. Mejta
Keyword(s):  
Lactic Acid ◽  
Fermentation Broth ◽  
Sodium Lactate ◽  
Final Concentration ◽  
Second Step ◽  
Slow Flow ◽  
Lactic Acid Concentration ◽  
Initial Concentration ◽  
Bipolar Membranes ◽  
Acid Recovery

The paper deals with the possibility of using two-stage electrodialysis for recovery of lactic acid from model solutions and from fermentation broth. In the first step lactate was concentrated with desalting electrodialysis using ion exchange membranes Ralex (Mega,Czech Republic). The highest final concentration of 111 g/l was reached in the concentrate, it means an increase more than 2.5-times in comparison with the initial concentration. At the most 2 g of lactate per litre remained in the feed. The second step was the electroconversion of sodium lactate to lactic acid by water-splitting electrodialysis with the bipolar membranes Neosepta (Tokuyama Corp.,Japan). The final lactic acid concentration of 157 g/l was reached in the diluate. Total required energy in both electrodialysis processes consisting of the energy consumption for lactate transfer and for its electroconversion to lactic acid was 142 Wh/mol. The fermentation broth was decolourised before electrodialysis experiments. The best decolourisation capacity was shown by granulated active charcoal filled in the column operated by a slow flow of broth.

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