scholarly journals Statistical Optimization of Lactic Acid Extraction Using Green Solvent and Mixed Extractants (TOA and TOMAC)

2020 ◽  
Vol 21 (1) ◽  
pp. 20-35
Author(s):  
Anil Kumar ◽  
Avinash Thakur
Keyword(s):  
Lactic Acid ◽  
Distribution Coefficient ◽  
Process Parameters ◽  
Chemical Engineering ◽  
Fermentation Broth ◽  
Mutual Effect ◽  
Reactive Extraction ◽  
Acid Extraction ◽  
Green Solvent ◽  
Separation And Purification

Since some previous years, reactive extraction has become more attractive and competitive technique for the separation and purification of lower carboxylic acids from fermentation broth as well as from dilute aqueous streams. This paper shows the results of investigation of reactive extraction of lactic acid (LA) from an aqueous solution using the synergistic mixture of the extractants (TOA (tri-n-octylamine) and TOMAC (Tri-n-octylmethylammonium chloride)) and a non-toxic and biocompatible green solvent (soybean oil). Three-level Box-Behnken design (BBD) under response surface methodology (RSM) was opted for the experimental design and to interpret the mutual effect of seven independent process parameters on the LA distribution coefficient (KD). The maximum values of LA distribution coefficient (KD=2.51) and its extraction efficiency (ηη=71.5%) were obtained for the optimum values of various process parameters such as 0.02 [M] initial LA concentration (CC1), 0.5 (v/v) extractant ratio (α), 28.66% (v/v) mixed extractants concentration (ψ), 2 (v/v) phase ratio (φ), 270C temperature (T), 102 rpm stirring speed (ω), and 63 mincontact time (τ). This present investigation will provide a noble discussion on LA reactive extraction using green solvent and on various influencing process parameters for gaining the enhanced value of LA distribution coefficient (KD). Chemical Engineering Research Bulletin 21(2019) 20-35

Recent advances in the separation and purification of lactic acid from fermentation broth

2021 ◽  
Vol 104 ◽  
pp. 142-151
Author(s):  
Chenglong Li ◽  
Ming Gao ◽  
Wenbin Zhu ◽  
Nuohan Wang ◽  
Xiaoyu Ma ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Fermentation Broth ◽  
Separation And Purification ◽  
Recent Advances

scholarly journals Reactive Extraction of Lactic Acid, Formic Acid and Acetic Acid from Aqueous Solutions with Tri-n-octylamine/1-Octanol/n-Undecane

2019 ◽  
Vol 3 (2) ◽  
pp. 43 ◽  
Author(s):  
Nuttakul Mungma ◽  
Marlene Kienberger ◽  
Matthäus Siebenhofer
Keyword(s):  
Mass Transfer ◽  
Acetic Acid ◽  
Lactic Acid ◽  
Formic Acid ◽  
Fermentation Broth ◽  
Lactic Acid Production ◽  
Mass Action ◽  
Reactive Extraction ◽  
Technical Application ◽  
Pka Value

The present work develops the basics for the isolation of lactic acid, acetic acid and formic acid from a single as well as a mixed feed stream, as is present, for example, in fermentation broth for lactic acid production. Modelling of the phase equilibria data is performed using the law of mass action and shows that the acids are extracted according to their pka value, where formic acid is preferably extracted in comparison to lactic and acetic acid. Back-extraction was performed by 1 M NaHCO3 solution and shows the same tendency regarding the pka value. Based on lactic acid, the solvent phase composition, consisting of tri-n-octylamine/1-octanol/n-undecane, was optimized in terms of the distribution coefficient. The data clearly indicate that, compared to physical extraction, mass transfer can be massively enhanced by reactive extraction. With increasing tri-n-octylamine and 1-octanol concentration, the equilibrium constant increases. However, even when mass transfer increases, tri-n-octylamine concentrations above 40 wt%, lead to third phase formation, which needs to be prevented for technical application. The presented data are the basis for the transfer to liquid membrane permeation, which enables the handling of emulsion tending systems.

Equilibrium and Kinetics of Reactive Extraction of Propionic Acid Using Aliquat 336 and Tri-n-Butyl Phosphate in n-Hexanol

2009 ◽  
Vol 7 (1) ◽  
Author(s):  
Dr. Kailas L. Wasewar ◽  
Amit Keshav ◽  
Shri Chand
Keyword(s):  
Propionic Acid ◽  
Acid Concentration ◽  
Fermentation Broth ◽  
Reactive Extraction ◽  
Acid Extraction ◽  
Aliquat 336 ◽  
Pseudo First Order Reaction ◽  
First Order ◽  
Pharmaceutical Industries ◽  
Kinetics Of

Recovery of propionic acid from different sources, like aqueous streams or from fermentation broth, is important in view of its wide usage in food, chemical and pharmaceutical industries. Reactive extraction is an emerging separation technique having numerous advantages like high selectivity and recovery. Effect of acid concentration, extractant concentration, pH, temperature and kinetics are the important steps in the reactive extraction. Equilibrium of propionic acid extraction using tri-n-butyl phosphate (TBP) and Aliquat 336 in n-hexanol respectively was carried out to find the better extractant out of the two for extraction of propionic acid. Aliquat 336 was found to be better than TBP with Ks = 2.2119 m3/kmol, thus indicating good complexation between it and the acid. The kinetics of extraction of the acid using Aliquat 336 in a stirred cell was investigated. The reaction was found to be first order in acid concentration and zero order in Aliquat 336 concentration. The reaction was found to be fast pseudo first order reaction occurring in the diffusion film and was found to be independent of hydrodynamics conditions. Rate constant was evaluated to be 163.398 1/s.

scholarly journals Reactive Extraction of Levulinic Acid using Tri-n-octylamine in 1-Octanol: Equilibria and Effect of pH

2020 ◽  
Vol 8 (5) ◽  
pp. 5252-5256
Keyword(s):  
Distribution Coefficient ◽  
Levulinic Acid ◽  
Extraction Efficiency ◽  
Fermentation Broth ◽  
Reactive Extraction ◽  
High Yield ◽  
Chemical Extraction ◽  
Effect Of Ph ◽  
Loading Ratio ◽  
Physical And Chemical

Reactive extraction is a sophisticated separation technique used for the recovery of carboxylic acids from fermentation broth. Levulinic acid is a versatile chemical. A right combination of extractant and diluent will provide a high yield. The reactive extraction of levulinic acid from aqueous solution with tri-n-octylamine (TOA) dissolved in 1-octanol was investigated at room temperature. The effect of pH was studied. From the physical and chemical equilibrium experimental results, the distribution coefficient (KD), extraction efficiency (E%), loading ratio (Z), stoichiometric loading factor (ZS) and modified separation factor (Sf ) are calculated. It was found that physical extraction provided less yield compared to chemical extraction. A maximum KD was obtained as 5.248 using 40% TOA (0.9059 mol/L) while 83.99 % of the levulinic acid was extracted. By increasing the initial concentration of levulinic acid increased the concentration of levulinic acid in both the organic phase and aqueous phase. As the concentration of TOA increases from 10 to 40 % (0.2264 mol/L to 0.9059 mol/L), the distribution coefficient and extraction efficiency also increase. By increasing the pH from 3 to 7, the distribution coefficient and extraction efficiency were drastically affected.

Separation and Purification of Lactic Acid from Fermentation Broth Using Membrane-Integrated Separation Processes

2017 ◽  
Vol 56 (29) ◽  
pp. 8301-8310 ◽  
Author(s):  
Hee Dae Lee ◽  
Min Yong Lee ◽  
Yoon Sung Hwang ◽  
Young Hoon Cho ◽  
Hyo Won Kim ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Fermentation Broth ◽  
Separation And Purification ◽  
Separation Processes

scholarly journals Design and Optimization of Lactic Acid Purification Process by Reactive Distillation with Isoamyl Alcohol

2021 ◽  
pp. 29-42
Author(s):  
Ying Wang ◽  
Jumei Xu ◽  
Zuoxiang Zeng ◽  
Weilan Xue ◽  
Zhijie Mao
Keyword(s):  
Lactic Acid ◽  
Process Parameters ◽  
Annual Cost ◽  
Reactive Distillation ◽  
Fermentation Broth ◽  
Isoamyl Alcohol ◽  
Total Annual Cost ◽  
Operating Pressure ◽  
Feed Composition ◽  
Yield And Purity

The purpose of this study was to investigate a continuous process for the recovery of lactic acid from fermentation broth. A reactive distillation process to purify lactic acid by esterification with isoamyl alcohol and hydrolysis was designed and simulated by Aspen. Five columns were included in the process: esterification column, purification column, hydrolysis column, dehydration column and recovery column. Effects of process parameters (operating pressure, feed composition, feed position, number of reaction and separation stages, and reboiler duty) of the esterification column on the yield and purity of lactic ester was evaluated. Further evaluation was carried out to reveal the effects of process parameters of the hydrolysis column on the yield and purity of lactic acid. The total annual cost of the whole process was calculated. Simulation studies are carried out using Aspen Plus RADFRAC module. It was shown that under the optimized condition, the concentration of lactic acid can reach up to 82.4 wt%, and the organic acid impurities were less than 3 ppm. Compared with the traditional usage of methanol and butanol, the isoamyl alcohol process can save about 20% of the total annual cost at the same output of lactic acid. Results obtained in this work can be used for scale-up study of an industrial reactive distillation operation as an efficient and economical alternative to recover lactic acid from fermentation broth.

scholarly journals Study of Lactic Acid Thermal Behavior Using Thermoanalytical Techniques

2017 ◽  
Vol 2017 ◽  
pp. 1-7 ◽  
Author(s):  
Andrea Komesu ◽  
Patricia Fazzio Martins Martinez ◽  
Betânia Hoss Lunelli ◽  
Johnatt Oliveira ◽  
Maria Regina Wolf Maciel ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Thermal Behavior ◽  
Fermentation Broth ◽  
High Reactivity ◽  
Vaporization Enthalpy ◽  
Separation And Purification ◽  
Scanning Calorimetry ◽  
Biotechnological Production ◽  
Separation Processes ◽  
Thermoanalytical Techniques

Actually, there is a growing interest in the biotechnological production of lactic acid by fermentation aiming to substitute fossil fuel routes. The development of an efficient method for its separation and purification from fermentation broth is very important to assure the economic viability of production. Due to its high reactivity and tendency to decompose at high temperatures, the study of lactic acid thermal behavior is essential for its separation processes and potential application. In the present study, differential scanning calorimetry (DSC) analyses showed endothermic peaks related to the process of evaporation. Data of thermogravimetry (TG/DTG) were correlated to Arrhenius and Kissinger equations to provide the evaporation kinetic parameters and used to determine the vaporization enthalpy. Activation energies were 51.08 and 48.37 kJ·mol−1 and frequency values were 859.97 and 968.81 s−1 obtained by Arrhenius and Kissinger equations, respectively. Thermogravimetry, coupled with mass spectroscopy (TG-MS), provided useful information about decomposition products when lactic acid was heated at 573 K for approximately 30 min.

Chemical engineering methods in downstream processing in biotechnology

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
V. Beschkov ◽  
D. Yankov
Keyword(s):  
Chemical Engineering ◽  
Fermentation Broth ◽  
Downstream Processing ◽  
Chemical Technology ◽  
Industrial Biotechnology ◽  
Separation And Purification ◽  
Product Concentration ◽  
Unit Operations ◽  
The Cost

AbstractDownstream processing in industrial biotechnology is a very important part of the overall bioproduct manufacturing. Sometimes the cost for this part of biotechnologies is up to 50% of the overall expenses. It comprises product concentration, separation and purification to different extents, as requested. The usually low product concentrations, the large volumes of fermentation broth and the product sensitivity toward higher temperatures lead to specific methods, similar but not identical to the ones in traditional chemical technology.This article summarizes briefly the unit operations in downstream processing in industrial biotechnology, making a parallel between biotechnology and chemical technology.

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