Identification of long and very long chain fatty acids, plasmalogen-C16:0 and phytanic acid as new lipid biomarkers in Tunisian coronary artery disease patients

2017 ◽  
Vol 131 ◽  
pp. 49-58 ◽  
Author(s):  
Samia Hadj Ahmed ◽  
Nadia Koubaa ◽  
Wafa Kharroubi ◽  
Amira Zarrouk ◽  
Amira Mnari ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Fatty Acids ◽  
Coronary Artery ◽  
Phytanic Acid ◽  
Lipid Biomarkers ◽  
Long Chain Fatty Acids ◽  
Artery Disease ◽  
Long Chain ◽  
Chain Fatty Acids

Role of SNPs of CPTIA and CROT genes in the carnitine-shuttle in coronary artery disease: a case-control study

2019 ◽  
Vol 44 (6) ◽  
pp. 822-830
Author(s):  
Aslihan Demircan ◽  
Ender Coskunpinar ◽  
Deniz Kanca ◽  
Gulcin Ozkara ◽  
Fatih Yanar ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Fatty Acids ◽  
Case Control Study ◽  
Threshold Value ◽  
Case Control ◽  
Long Chain Fatty Acids ◽  
Artery Disease ◽  
Control Study ◽  
Long Chain

Abstract Objective Fatty acid β-oxidation defects can lead to difficulties at covering energy requirement of heart. The carnitine-shuttle is responsible for the transfering of long-chain fatty acids from the internal mitochondrial membrane. The role of genetic variants of the enzymes in the carnitine shuttle in coronary artery disease (CAD) has not been studied. Therefore, we performed a case-control study investigating the possible relation between the CPTIA-rs3019613 and CROT-rs2214930 gene variations located carnitine shuttle and CAD risk. Materials and methods Study groups were comprised of 96 CAD patients and 85 controls. CPTIA-rs3019613 G > A and CROT-rs2214930 T > C polymorphisms were determined by real-time-PCR. Results The CROT-rs2214930-CC genotype was found to be associated with decreased HDL-cholesterol (HDL-C) in controls (p = 0.029). In patients with CPTIA-rs3019613-A allele, body mass index (BMI) (p = 0.016) and BMI threshold-value (p = 0.030) were found be higher compared to those with GG-genotype, while HDL-C threshold-value (HDL-C ≤ 0.90 mmol/L) was found to be lower (p = 0.015). Regression analysis confirmed CPTIA-rs3019613-A allele has a significant relationship with decreased HDL-C (p = 0.009) in patients. Conclusion Our study indicated that the polymorphisms of the CROT and CPTIA genes related to β-oxidation of long-chain fatty acids had an important effect on serum HDL-C levels and may be a potential risk for CAD.

The opposite associations of long-chain versus very long-chain monounsaturated fatty acids with mortality among patients with coronary artery disease

Heart ◽  
2014 ◽  
Vol 100 (20) ◽  
pp. 1597-1605 ◽  
Author(s):  
Zhongxia Li ◽  
Yuan Zhang ◽  
Dongfang Su ◽  
Xiaofei Lv ◽  
Min Wang ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Fatty Acids ◽  
Coronary Artery ◽  
Monounsaturated Fatty Acids ◽  
Artery Disease ◽  
Long Chain
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