Reduced platelet [3H]paroxetine binding in anorexia nervosa: Relationship to eating symptoms and personality pathology

2006 ◽  
Vol 142 (2-3) ◽  
pp. 225-232 ◽  
Author(s):  
Kenneth R. Bruce ◽  
Howard Steiger ◽  
N.M.K. Ng Ying Kin ◽  
Mimi Israel
Keyword(s):  
Anorexia Nervosa ◽  
Personality Pathology ◽  
Paroxetine Binding

A pilot study of personality pathology in patients with anorexia nervosa: Modifiable factors related to outcome after hospitalization

2009 ◽  
Vol 14 (2-3) ◽  
pp. e113-e120 ◽  
Author(s):  
L. M. McCormick ◽  
P. K. Keel ◽  
M. C. Brumm ◽  
D. B. Watson ◽  
V. L. Forman-Hoffman ◽  
...  
Keyword(s):  
Anorexia Nervosa ◽  
Pilot Study ◽  
Personality Pathology ◽  
Modifiable Factors

Do illness characteristics and familial risk differ between women with anorexia nervosa grouped on the basis of personality pathology?

2005 ◽  
Vol 36 (4) ◽  
pp. 529-538 ◽  
Author(s):  
JOANNA HOLLIDAY ◽  
SABINE LANDAU ◽  
DAVID COLLIER ◽  
JANET TREASURE
Keyword(s):  
Anorexia Nervosa ◽  
Clinical Symptoms ◽  
Familial Risk ◽  
Emotional Dysregulation ◽  
Self Report ◽  
Personality Pathology ◽  
Eating Disordered ◽  
Dsm Iv ◽  
Dimensional Assessment ◽  
High Inhibition

Background. In view of the potential utility of personality-based groupings in eating disorders (EDs), and the lack of studies using this approach in large samples of individuals with anorexia nervosa (AN), this study set out to examine (i) the nature of personality-based clusters of women with lifetime AN and (ii) if these clusters are associated with either clinical symptoms or aetiological variables.Method. The self-report Dimensional Assessment of Personality Pathology (DAPP) was completed by 153 women with a lifetime diagnosis of DSM-IV AN. A cluster analysis was used to identify personality-based subgroups. Clusters were then compared on clinical and aetiological variables.Results. Three personality-based clusters were identified, defined by broad, avoidant and compulsive types of personality pathology. Dimensions of low dissocial behaviour, high inhibition and high compulsivity were common to all clusters, while dimensions related to emotional dysregulation appeared more heterogeneous. Clinical symptoms were not related to personality profile with the exception of a trend towards more fasting behaviour in the broad group. The compulsive cluster with the narrowest range of extreme personality traits reported the highest familial risk of eating pathology.Conclusions. The three clusters identified in our AN sample were similar to those previously identified in broader eating disordered samples. Personality-based clusters did not correspond overall to clinical symptoms but aetiological differences supported their validity. Broader personality pathology indicative of emotional dysregulation, problems with identity and relationships, in addition to core traits, may increase vulnerability to AN in those with less familial risk.

Personality Pathology Among Individuals With a Lifetime History of Anorexia Nervosa

2006 ◽  
Vol 20 (4) ◽  
pp. 417-430 ◽  
Author(s):  
Joanna Holliday ◽  
Rudolf Uher ◽  
Sabine Landau ◽  
David Collier ◽  
Janet Treasure
Keyword(s):  
Anorexia Nervosa ◽  
Personality Pathology ◽  
Lifetime History ◽  
History Of

Eine internationale neuropsychologische Testbatterie für Kinder, Jugendliche und Erwachsene mit Anorexia nervosa – die deutsche Adaptation des Ravello Profils

2013 ◽  
Vol 41 (6) ◽  
pp. 371-381 ◽  
Author(s):  
Betteke Maria van Noort ◽  
Ernst Pfeiffer ◽  
Ulrike Lehmkuhl ◽  
Viola Kappel
Keyword(s):  
Anorexia Nervosa

Fragestellung: Erwachsene mit Anorexia nervosa (AN) zeigen vor und nach Gewichtsrehabilitation Beeinträchtigungen kognitiver Funktionen. Im Bereich der kindlichen und früh-adoleszenten AN besteht ein großer Bedarf an strukturierten Untersuchungen der kognitiven Funktionen. Bisherige Studien weisen methodische Inkonsistenzen bezüglich der Testauswahl und der Operationalisierung kognitiver Funktionen auf, die die Interpretierbarkeit und Vergleichbarkeit der Befunde deutlich einschränken. Um diese Inkonsistenzen zu verringern, wurde eine neuropsychologische Testbatterie, das sogenannte „Ravello Profil“ entwickelt, das bisher jedoch nicht für den deutschen Sprachraum zur Verfügung steht. Die vorliegende Arbeit stellt daher eine für den deutschen Sprachraum adaptierte Version des Ravello Profils vor und überprüft dessen Anwendbarkeit im Kindes- und Jugendalter. Methodik: Das Ravello Profil wurde für den deutschen Sprachraum adaptiert. Anhand von drei Fallbeispielen wurde die Durchführbarkeit des Ravello Profils bei Kindern und Jugendlichen mit AN überprüft. Ergebnisse und Schlussfolgerungen: Die Fallbeispiele verdeutlichen die Anwendbarkeit des adaptierten Ravello Profils bei Kindern und Jugendlichen mit AN. Das Ravello Profil ermöglicht somit auch im deutschen Sprachraum methodisch konsistente Untersuchungen kognitiver Funktionen bei Kindern, Jugendlichen und Erwachsenen mit AN. Mithilfe des Ravello Profils kann die Rolle kognitiver Funktionen bei der Entstehung einer AN über eine umfassende Altersspanne systematisch untersucht werden.

Perception of Autonomy and Connectedness Prior to the Onset of Anorexia Nervosa and Bulimia Nervosa

2012 ◽  
Vol 40 (1) ◽  
pp. 61-68 ◽  
Author(s):  
Julia Huemer ◽  
Maria Haidvogl ◽  
Fritz Mattejat ◽  
Gudrun Wagner ◽  
Gerald Nobis ◽  
...  
Keyword(s):  
Anorexia Nervosa ◽  
Risk Factor ◽  
Bulimia Nervosa ◽  
Family Environment ◽  
Significant Influence ◽  
Diagnostic Interview ◽  
Individual Autonomy ◽  
Mothers And Fathers ◽  
Image Test ◽  
Restrictive Type

Objective: This study examines retrospective correlates of nonshared family environment prior to onset of disease, by means of multiple familial informants, among anorexia and bulimia nervosa patients. Methods: A total of 332 participants was included (anorexia nervosa, restrictive type (AN-R): n = 41 plus families); bulimic patients (anorexia nervosa, binge-purging type; bulimia nervosa: n = 59 plus families). The EATAET Lifetime Diagnostic Interview was used to establish the diagnosis; the Subjective Family Image Test was used to derive emotional connectedness (EC) and individual autonomy (IA). Results: Bulimic and AN-R patients perceived significantly lower EC prior to onset of disease compared to their healthy sisters. Bulimic patients perceived significantly lower EC prior to onset of disease compared to AN-R patients and compared to their mothers and fathers. A low family sum – sister pairs sum comparison – of EC had a significant influence on the risk of developing bulimia nervosa. Contrary to expectations, AN-R patients did not perceive significantly lower levels of IA compared to their sisters, prior to onset of disease. Findings of low IA in currently ill AN-R patients may represent a disease consequence, not a risk factor. Conclusions: Developmental child psychiatrists should direct their attention to disturbances of EC, which may be present prior to the onset of the disease.

Morphological Changes in the Brain of Acutely Ill and Weight-Recovered Patients with Anorexia Nervosa

2014 ◽  
Vol 42 (1) ◽  
pp. 7-18 ◽  
Author(s):  
Jochen Seitz ◽  
Katharina Bühren ◽  
Georg G. von Polier ◽  
Nicole Heussen ◽  
Beate Herpertz-Dahlmann ◽  
...  
Keyword(s):  
Anorexia Nervosa ◽  
Cognitive Deficits ◽  
Time Course ◽  
Morphological Changes ◽  
Meta Analysis ◽  
Short Term ◽  
Clinical Prognosis ◽  
Qualitative Review ◽  
Brain Changes ◽  
The Brain

Objective: Acute anorexia nervosa (AN) leads to reduced gray (GM) and white matter (WM) volume in the brain, which however improves again upon restoration of weight. Yet little is known about the extent and clinical correlates of these brain changes, nor do we know much about the time-course and completeness of their recovery. Methods: We conducted a meta-analysis and a qualitative review of all magnetic resonance imaging studies involving volume analyses of the brain in both acute and recovered AN. Results: We identified structural neuroimaging studies with a total of 214 acute AN patients and 177 weight-recovered AN patients. In acute AN, GM was reduced by 5.6% and WM by 3.8% compared to healthy controls (HC). Short-term weight recovery 2–5 months after admission resulted in restitution of about half of the GM aberrations and almost full WM recovery. After 2–8 years of remission GM and WM were nearly normalized, and differences to HC (GM: –1.0%, WM: –0.7%) were no longer significant, although small residual changes could not be ruled out. In the qualitative review some studies found GM volume loss to be associated with cognitive deficits and clinical prognosis. Conclusions: GM and WM were strongly reduced in acute AN. The completeness of brain volume rehabilitation remained equivocal.

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