Single dose testosterone administration reduces loss chasing in healthy females

Our aim was to investigate whether plasma l-arginine and asymmetric dimethylarginine (ADMA) concentrations and nitric oxide (NO) production are altered in male idiopathic hypogonadotropic hypogonadism (IHH) patients in the hypogonadal state and after single dose testosterone administration compared with those in control subjects. Eighteen newly diagnosed male patients with IHH and 20 healthy volunteer controls matched by age and body mass index were enrolled in the study. Single dose testosterone was administrated im. Initially, pretreatment blood samples were collected after overnight fasting. Posttreatment blood samples were drawn 10 d after the injection. ADMA, l-arginine, and NO were measured in pre- and posttreatment blood samples. The pretreatment ADMA and l-arginine levels were significantly higher, and plasma nitrite plus nitrate (NOx) levels were lower than those in the control group. After 10 d of treatment, ADMA and l-arginine levels were significantly reduced, and NOx levels were significantly increased. There was a significant positive correlation (P < 0.01) between ADMA and l-arginine and a negative correlation between ADMA and NOx levels in patients and controls. In conclusion, the patients with IHH showed elevated plasma ADMA levels associated with a reduction in NO production. Single dose parenteral T administration lowered ADMA concentrations and increased NO production to the control group values.

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Effect of a single-dose of olanzapine on sleep in healthy females and males

International Clinical Psychopharmacology ◽

10.1097/00004850-200207000-00004 ◽

2002 ◽

Vol 17 (4) ◽

pp. 177-184 ◽

Cited By ~ 33

Author(s):

N. Lindberg ◽

M. Virkkunen ◽

P. Tani ◽

B. Appelberg ◽

J. Virkkala ◽

...

Keyword(s):

Single Dose ◽

Healthy Females

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Testosterone modulates preattentive sensory processing and involuntary attention switches to emotional voices

Journal of Neurophysiology ◽

10.1152/jn.00587.2014 ◽

2015 ◽

Vol 113 (6) ◽

pp. 1842-1849 ◽

Cited By ~ 12

Author(s):

Chenyi Chen ◽

Chin-Yau Chen ◽

Chih-Yung Yang ◽

Chi-Hung Lin ◽

Yawei Cheng

Keyword(s):

Single Dose ◽

Sensory Processing ◽

Acute Effect ◽

Oddball Paradigm ◽

Involuntary Attention ◽

Double Blind ◽

Voice Perception ◽

Auditory Oddball ◽

Healthy Female ◽

Testosterone Administration

Testosterone is capable of altering facial threat processing. Voices, similar to faces, convey social information. We hypothesized that administering a single dose of testosterone would change voice perception in humans. In a placebo-controlled, randomly assigned, double-blind crossover design, we administered a single dose of testosterone or placebo to 18 healthy female volunteers and used a passive auditory oddball paradigm. The mismatch negativity (MMN) and P3a in responses to fearfully, happily, and neutrally spoken syllables dada and acoustically matched nonvocal sounds were analyzed, indicating preattentive sensory processing and involuntary attention switches. Results showed that testosterone administration had a trend to shorten the peak latencies of happy MMN and significantly enhanced the amplitudes of happy and fearful P3a, whereas the happy- and fearful-derived nonvocal MMN and P3a remained unaffected. These findings demonstrated acute effect of testosterone on the neural dynamics of voice perception. Administering a single dose of testosterone modulates preattentive sensory processing and involuntary attention switches in response to emotional voices.

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