Physics-based modeling of cosmogenic nuclides part II – Key aspects of in-situ cosmogenic nuclide production

2015 ◽  
Vol 26 ◽  
pp. 44-55 ◽  
Author(s):  
David C. Argento ◽  
John O. Stone ◽  
Robert C. Reedy ◽  
Keran O'Brien
Author(s):  
Rainer Wieler

Cosmogenic nuclides are produced by the interaction of energetic elementary particles of galactic (or solar) cosmic radiation and their secondaries with atomic nuclei in extraterrestrial or terrestrial material. Cosmogenic nuclides usually are observable only for some noble gas isotopes, whose natural abundances in the targets of interest are exceedingly low; some radioactive isotopes with half-lives mostly in the million-year range; and a few stable nuclides of elements, such as Gd and Sm, whose abundance is sizably modified by reactions with low energy secondary cosmic ray neutrons. In solid matter, the mean attenuation length of galactic cosmic ray protons is on the order of 50 cm. Therefore, cosmogenic nuclides are a major tool in studying the history of small objects in space and of matter near the surfaces of larger parent bodies. A classical application is to measure “exposure ages” of meteorites, namely the time they spent as a small body in interplanetary space. In some cases, also the previous history of the future meteorite in its parent-body regolith can be constrained. Such information helps to understand delivery mechanisms of meteorites from their parent asteroids or parent planets and to constrain the number of ejection events responsible for the collected meteorites. Cosmogenic nuclides in lunar samples from known depths of up to ~2 m serve to study the deposition and mixing history of the lunar regolith over hundreds of millions of years, as well as to calibrate nuclide production models. Present and future sample return missions rely on cosmogenic nuclide measurements as important tools to constrain the sample’s exposure history or loss rates of their parent body surfaces to space. The first data from cosmogenic noble gas isotopes measured on the surface of Mars demonstrate that the exposure and erosional history of planetary bodies can be obtained by in-situ analyses. For the foreseeable future, exposure ages of presolar grains in meteorites are presumably the only means to quantitatively constrain their presolar history. In some cases, irradiation effects of energetic particles from the early sun can be detected in early solar system condensates, confirming that the early sun was likely much more active than today, as expected from observations of young stars. The ever-increasing precision of isotope analyses also reveals tiny isotopic anomalies induced by cosmic-ray effects in several elements of interest in cosmochemistry, which need to be recognized and corrected for. Cosmogenic nuclide studies rely on the knowledge of their production rates, which depend on the elemental composition of a sample and its “shielding” during irradiation, that is, its position within an irradiated object and for meteorites their preatmospheric size. The physics of cosmogenic nuclide production is basically well understood and has led to sophisticated production models. They are most successful if a sample’s shielding can be constrained by the analyses of several cosmogenic nuclides with different depth dependencies of their production rates. Cosmogenic nuclides are also an important tool in Earth Sciences. The foremost example is 14C produced in the atmosphere and incorporated into organic material, which is used for dating. Cosmogenic radionuclides and noble gases produced in-situ in near surface samples, mostly by secondary cosmic-ray neutrons, are an important tool in quantitative geomorphology and related fields.


Radiocarbon ◽  
1996 ◽  
Vol 38 (1) ◽  
pp. 135-147 ◽  
Author(s):  
John C. Gosse ◽  
Robert C. Reedy ◽  
Charles D. Harrington ◽  
Jane Poths

Measurements of cosmogenic nuclides made in situ in the Earth's surface are being used to help resolve a wide range of geologic and chronologic questions. Cosmogenic nuclides (3He, 10Be, 14C, 21Ne, 26Al 36C1 are presently used) can reveal rock exposure history information leading to estimates of timing of surface forming events, rates and styles of erosion, and timing and durations of episodes of burial. Depending on the problems being tackled, a significant source of error (±10–25%) for any cosmogenic nuclide method is the present uncertainty in the spatial and temporal variability of the rates of production of these in-situ nuclides.


2008 ◽  
Vol 57 (1/2) ◽  
pp. 226-238
Author(s):  
Naki Akcar ◽  
Susan Ivy-Ochs ◽  
Christian Schlüchter

Abstract. The wide applicability of in-situ produced Terrestrial Cosmogenic Nuclides (TCNs) to geological problems and experiences in development and testing gained over the past decade is encouraging for its application to archaeological questions, where there is a distinct need for an additional independent dating tool beyond the limits of radiocarbon (~ 40 ka). Just as TCNs are applicable to a broader time period with considerable precision in archaeology, so also are they applicable to all lithologies. Application of TCNs to archaeological problems is relatively simple: either surface exposure dating (using cosmogenic nuclide production) or burial dating (using decay of radioactive cosmogenic nuclides) can be applied. For a successful application, close collaboration between archaeologists and TCN experts is required. The total exposure from 100 a to 5 Ma of a given surface of archaeological origin can be determined by surface exposure dating. The range of burial dating is from ~0.1 to 5 Ma. TCNs have been successfully applied to many archaeological problems during the last decade and both surface exposure dating and burial dating show high potential in the solving of archaeological problems.


2021 ◽  
Vol 22 (9) ◽  
pp. 4732
Author(s):  
Vincenza Ylenia Cusenza ◽  
Alessandra Bisagni ◽  
Monia Rinaldini ◽  
Chiara Cattani ◽  
Raffaele Frazzi

The cytogenetic and molecular assessment of deletions, amplifications and rearrangements are key aspects in the diagnosis and therapy of cancer. Not only the initial evaluation and classification of the disease, but also the follow-up of the tumor rely on these laboratory approaches. The therapeutic choice can be guided by the results of the laboratory testing. Genetic deletions and/or amplifications directly affect the susceptibility or the resistance to specific therapies. In an era of personalized medicine, the correct and reliable molecular characterization of the disease, also during the therapeutic path, acquires a pivotal role. Molecular assays like multiplex ligation-dependent probe amplification and droplet digital PCR represent exceptional tools for a sensitive and reliable detection of genetic alterations and deserve a role in molecular oncology. In this manuscript we provide a technical comparison of these two approaches with the golden standard represented by fluorescence in situ hybridization. We also describe some relevant targets currently evaluated with these techniques in solid and hematologic tumors.


2021 ◽  
Author(s):  
Olivier Duriez ◽  
Jovan Andevski ◽  
Christopher G. R. Bowden ◽  
Alvaro Camiña-Cardenal ◽  
Hans Frey ◽  
...  

ABSTRACT Although vulture feeding stations are a widely used tool for vulture conservation in many regions worldwide, there has been some confusion about their functions and this is reflected in the range of terminology used. The origin of food supply at provisioning sites (both for in situ and ex situ situations) and the goals of feeding station managers (ranging from purely conservation of vultures to the necessity for carcass disposal) are two key aspects that are often neglected. We review the definitions and nomenclature for the provision of predictable anthropogenic food for vultures and vultures' role in sanitation in the landscape. We propose that “supplementary feeding stations for vultures” (SFSV) defines a particular case and this term should only be applied when a station has vulture conservation goals and a food supply coming from outside of the landscape (ex situ). We introduce the term “recycling station with vultures” (RSV) for cases when the goal is the elimination of carcasses and the food is sourced in situ (natural, NRSV) or ex situ (supplementary food, SRSV). This clarification of goals and terminology for feeding stations worldwide could have important consequences for the understanding and assessment of vulture conservation and management actions, among researchers and conservationists and also importantly among stakeholders and wider society.


2021 ◽  
Author(s):  
Evin Magner ◽  
Pamela Sandoval-Sanchez ◽  
Peter F Hitchcock ◽  
Scott M Taylor

Abstract In mammals, photoreceptor loss causes permanent blindness, but in zebrafish (Danio rerio), Müller glia function as intrinsic stem cells, producing progenitor cells that regenerate photoreceptors and restore vision. MicroRNAs (miRNAs) critically regulate neurogenesis in the brain and retina, but the roles of miRNAs in injury-induced neuronal regeneration are largely unknown. The miRNA miR-18a regulates photoreceptor differentiation in the embryonic retina. The purpose of the current study was to determine the function of miR-18a during injury-induced photoreceptor regeneration. RT-qPCR, in-situ hybridization (ISH) and immunohistochemistry (IHC) showed that miR-18a expression increases throughout the retina by 1-day post-injury (dpi) and continues to increase through 5 dpi. Bromodeoxyuridine (BrdU) labeling showed that at 7 and 10 dpi, when regenerated photoreceptors are normally differentiating, there are more proliferating Müller glia-derived progenitors in homozygous miR-18a mutant (miR-18ami5012) retinas compared with wild type (WT), indicating that miR-18a negatively regulates injury-induced proliferation. At 7 and 10 dpi, miR-18ami5012 retinas have fewer mature photoreceptors than WT, but there is no difference at 14 dpi, revealing that photoreceptor regeneration is delayed. BrdU labeling showed that the excess progenitors in miR-18ami5012 retinas migrate to other retinal layers besides the photoreceptor layer. Inflammation is critical for photoreceptor regeneration and RT-qPCR showed that, in the absence of miR-18a, inflammation is prolonged. Suppressing inflammation with dexamethasone rescues the miR-18ami5012 phenotype. Together, these data show that during injury-induced photoreceptor regeneration, miR-18a regulates proliferation and photoreceptor regeneration by regulating key aspects of the inflammatory response during photoreceptor regeneration in zebrafish.


2015 ◽  
Vol 26 ◽  
pp. 56-69 ◽  
Author(s):  
Nathaniel Lifton ◽  
Marc Caffee ◽  
Robert Finkel ◽  
Shasta Marrero ◽  
Kunihiko Nishiizumi ◽  
...  

2019 ◽  
Vol 13 (11) ◽  
pp. 2935-2951 ◽  
Author(s):  
Keir A. Nichols ◽  
Brent M. Goehring ◽  
Greg Balco ◽  
Joanne S. Johnson ◽  
Andrew S. Hein ◽  
...  

Abstract. We describe new Last Glacial Maximum (LGM) ice thickness constraints for three locations spanning the Weddell Sea Embayment (WSE) of Antarctica. Samples collected from the Shackleton Range, Pensacola Mountains, and the Lassiter Coast constrain the LGM thickness of the Slessor Glacier, Foundation Ice Stream, and grounded ice proximal to the modern Ronne Ice Shelf edge on the Antarctic Peninsula, respectively. Previous attempts to reconstruct LGM-to-present ice thickness changes around the WSE used measurements of long-lived cosmogenic nuclides, primarily 10Be. An absence of post-LGM apparent exposure ages at many sites led to LGM thickness reconstructions that were spatially highly variable and inconsistent with flow line modelling. Estimates for the contribution of the ice sheet occupying the WSE at the LGM to global sea level since deglaciation vary by an order of magnitude, from 1.4 to 14.1 m of sea level equivalent. Here we use a short-lived cosmogenic nuclide, in situ-produced 14C, which is less susceptible to inheritance problems than 10Be and other long-lived nuclides. We use in situ 14C to evaluate the possibility that sites with no post-LGM exposure ages are biased by cosmogenic nuclide inheritance due to surface preservation by cold-based ice and non-deposition of LGM-aged drift. Our measurements show that the Slessor Glacier was between 310 and up to 655 m thicker than present at the LGM. The Foundation Ice Stream was at least 800 m thicker, and ice on the Lassiter Coast was at least 385 m thicker than present at the LGM. With evidence for LGM thickening at all of our study sites, our in situ 14C measurements indicate that the long-lived nuclide measurements of previous studies were influenced by cosmogenic nuclide inheritance. Our inferred LGM configuration, which is primarily based on minimum ice thickness constraints and thus does not constrain an upper limit, indicates a relatively modest contribution to sea level rise since the LGM of < 4.6 m, and possibly as little as < 1.5 m.


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