Automated delineation of the clinical target volume using anatomically constrained 3D expansion of the gross tumor volume

2020 ◽  
Vol 146 ◽  
pp. 37-43 ◽  
Author(s):  
Nadya Shusharina ◽  
Jonas Söderberg ◽  
David Edmunds ◽  
Fredrik Löfman ◽  
Helen Shih ◽  
...  
Keyword(s):  
Gross Tumor Volume ◽  
Clinical Target Volume ◽  
Tumor Volume ◽  
Target Volume

scholarly journals Pattern of Recurrence of Glioblastoma Versus Grade 4 IDH-Mutant Astrocytoma Following Chemoradiation

2021 ◽  
Author(s):  
James Stewart ◽  
Arjun Sahgal ◽  
Aimee K.M. Chan ◽  
Hany Soliman ◽  
Chia-Lin Tseng ◽  
...  
Keyword(s):  
Gross Tumor Volume ◽  
Clinical Target Volume ◽  
Tumor Volume ◽  
Extent Of Resection ◽  
Target Volume ◽  
Radiotherapy Planning ◽  
Recurrence Pattern ◽  
Wild Type ◽  
Failure Patterns ◽  
Pattern Of Recurrence

Abstract Purpose To quantitatively compare the recurrence pattern of glioblastoma (IDH-wild type) versus grade 4 IDH-mutant astrocytoma (herein referred to as wtIDH and mutIDH, respectively) following primary chemoradiation. Methods Twenty-two wtIDH and 22 mutIDH patients matched by sex, extent of resection, and corpus callosum involvement were enrolled. The recurrent gross tumor volume (rGTV) was compared with both the gross tumor volume (GTV) and clinical target volume (CTV) from radiotherapy planning. Failure patterns were quantified by the incidence and volume of the rGTV outside the GTV and CTV, and positional differences of the rGTV centroid from the GTV and CTV. Results The GTV was smaller in wtIDH compared to the mutIDH group (mean±SD: 46.5±26.0 cm3 v. 72.2±45.4 cm3, p=0.026). The rGTV was 10.7±26.9 cm3 and 46.9±55.0 cm3 smaller than the GTV for the same groups (p=0.018). The rGTV extended outside the GTV in 22 (100%) and 15 (68%) (p=0.009) of wtIDH and mutIDH patients, respectively; however, the volume of rGTV outside the GTV was not significantly different (12.4±16.1 cm3 vs. 8.4±14.2 cm3, p=0.443). The rGTV metrics extending outside the CTV was not different between the groups. The rGTV centroid was within 5.7 mm of the closest GTV edge for 21 (95%) and 22 (100%) of wtIDH and mutIDH patients, respectively. Conclusion The rGTV extended beyond the GTV less often in mutIDH patients, suggesting limited margin radiotherapy could be beneficial in this group. The results support the study of small margin adaptive radiotherapy per the ongoing UNITED MR-Linac 5 mm CTV trial (NCT04726397).

Gross tumor volume and clinical target volume in prostate cancer: How do satellites relate to the index lesion

2015 ◽  
Vol 115 (1) ◽  
pp. 96-100 ◽  
Author(s):  
Birgit G. Hollmann ◽  
Baukelien van Triest ◽  
Ghazaleh Ghobadi ◽  
Greetje Groenendaal ◽  
Jeroen de Jong ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Gross Tumor Volume ◽  
Clinical Target Volume ◽  
Tumor Volume ◽  
Target Volume ◽  
Index Lesion

On the Delineation of the Gross Tumor Volume and Clinical Target Volume for Head and Neck Squamous Cell Carcinomas

2001 ◽  
Vol 87 (3) ◽  
pp. 152-161 ◽  
Author(s):  
Giuseppe Sanguineti ◽  
Franca Foppiano ◽  
Michela Marcenaro ◽  
Federico Roncallo ◽  
Renzo Corvò ◽  
...  
Keyword(s):  
Head And Neck ◽  
Squamous Cell ◽  
Gross Tumor Volume ◽  
Clinical Target Volume ◽  
Tumor Volume ◽  
Target Volume ◽  
Squamous Cell Carcinomas

Gross Tumor Volume and Clinical Target Volume

2008 ◽  
pp. 225-234
Author(s):  
Ernesto Brianzoni ◽  
Gloria Rossi ◽  
Alfredo Proietti
Keyword(s):  
Gross Tumor Volume ◽  
Clinical Target Volume ◽  
Tumor Volume ◽  
Target Volume

Computed Tomographic–Pathologic Correlation of Gross Tumor Volume and Clinical Target Volume in Non–Small Cell Lung Cancer

2001 ◽  
Vol 125 (11) ◽  
pp. 1469-1472
Author(s):  
Roscoe Chan ◽  
Yu He ◽  
Abida Haque ◽  
Joseph Zwischenberger
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Gross Tumor Volume ◽  
Clinical Target Volume ◽  
Tumor Volume ◽  
Target Volume ◽  
Small Cell ◽  
Small Cell Lung ◽  
Computed Tomographic

Abstract Context.—Computed tomographic (CT) scan data are used regularly in radiation treatment planning for patients with lung cancer. To our knowledge, the relationship of the CT images of tumors and their corresponding microscopic extent has not yet been studied in detail. Objective.—To correlate tumor sizes on CT with tumor sizes measured microscopically (ie, the gross tumor volume [GTV]-clinical target volume margin) in non–small cell lung cancers. Design.—Prospective pilot study. Setting.—Single institution. Patients.—Patients with operable non–small cell lung cancer were identified preoperatively. Interventions.—Once the surgical specimen was available, it was oriented with the surgeon and the pathologist. Seven whole-mount, cross-sectional histologic glass slides were made from 5 tumors using formalin fixation and hematoxylin-eosin staining. The pathologist then outlined the cancer-containing area under the microscope (Micro-GTV) and the area of surrounding inflammatory response (Micro-GTV + inflammation). Preoperative CT scans were used for outlining tumor on the corresponding slice (CT-GTV). Main Outcome Measures.—Correlation of the areas of Micro-GTV, Micro-GTV + inflammation, and CT-GTV was performed. Results.—There was an obvious trend that the CT-GTV was bigger than the Micro-GTV, except in specimen 1, in which the 2 areas were about equal. However, on comparing the values for the CT-GTV and the Micro-GTV + inflammation, the difference between the 2 areas became smaller. Conclusions.—Modern CT scans might overestimate the GTV in non–small cell lung cancer. The GTV–clinical target volume margin could actually be zero or even a negative value. The findings in this small study are interesting and provoking. Further study with a larger number of patients and more rigid quality control is warranted to confirm our findings.

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