Do the traits of autism-spectrum overlap with those of schizophrenia or obsessive-compulsive disorder in the general population?

2012 ◽  
Vol 6 (2) ◽  
pp. 717-725 ◽  
Author(s):  
Akio Wakabayashi ◽  
Simon Baron-Cohen ◽  
Chris Ashwin
Keyword(s):  
General Population ◽  
Obsessive Compulsive Disorder ◽  
Autism Spectrum ◽  
Obsessive Compulsive ◽  
Compulsive Disorder

scholarly journals The prevalence of autism spectrum traits and autism spectrum disorders in children and adolescents with obsessive compulsive disorder: a systematic review

BJPsych Open ◽  
2021 ◽  
Vol 7 (S1) ◽  
pp. S56-S56
Author(s):  
Claire Tiley ◽  
Marinos Kyriakopoulos
Keyword(s):  
Systematic Review ◽  
Children And Adolescents ◽  
Obsessive Compulsive Disorder ◽  
Functional Impairment ◽  
Body Dysmorphic Disorder ◽  
Autism Spectrum ◽  
Control Group ◽  
Obsessive Compulsive ◽  
Global Functioning ◽  
Compulsive Disorder

AimsAutism Spectrum Disorder (ASD) and Obsessive Compulsive Disorder (OCD) commonly co-occur in children and adolescents (C&A); evidence suggests functional impairment is increased in those diagnosed with both disorders. The aims of this systematic review were: 1) To review studies that report on the prevalence of ASD traits and/or diagnosis in C&A with OCD. 2) To review whether the severity of OCD symptoms is related to the severity of ASD traits in C&A with OCD. 3)To review whether the severity of comorbid ASD traits or diagnosis in C&A with OCD impact on their global functioning.MethodThis systematic review was registered in PROSPERO. Prisma guidelines were followed . Electronic searches were carried out on Pubmed, EMBASE and Psychinfo with the use of selected keywords. Inclusion criteria : 1) Participants up to the age of 18 who had an ICD or DSM diagnosis of OCD. 2) Journal articles published in the English, with no date specifications. 3) Papers evaluating ASD diagnosis or traits, or where data on this could be extracted. Exclusion criteria: 1) Papers looking at OCD related disorders such as body dysmorphic disorder, compulsive skin picking, trichotillomania and hoarding disorder. 2) Samples including adults where C&A data could not be extracted. 3) Posters, abstracts and dissertations.ResultA total of 15 studies were included in the systematic review. Seven of these studies directly compared the prevalence of ASD traits (measured by questionnaires) or diagnosis in OCD to a control group or normative data, with all studies reporting a significant elevation in ASD trait scores and diagnosis in OCD. Ten of the studies reported on the correlation between ASD trait severity and OCD severity. Four studies identified a significant correlation between ASD and OCD total scores or specified subscales. In contrast, one study found significantly elevated OCD scores in an OCD only group when compared to a comorbid OCD and ASD group. Three studies reported on the correlation between ASD scores and functional impairment or compared an OCD only group to a comorbid group. All three studies demonstrated that the presence ASD or ASD traits are associated with elevated scores in global functional impairment.ConclusionIn conclusion, this review suggests that there is an increased prevalence of ASD traits and diagnosis amongst C&A with OCD. Elevated ASD traits within this population are associated with a greater impact on global functioning.

Emotional response bias, autistic traits and paranormal beliefs in patients with OCD

2021 ◽  
pp. 1-13
Author(s):  
Ayesha Ashraf ◽  
Rabia Iftikhar
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Response Bias ◽  
Emotional Response ◽  
Recognition Task ◽  
Autistic Traits ◽  
Autism Spectrum ◽  
Autism Spectrum Quotient ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Paranormal Beliefs

Objective: To find the relationship involving autistic traits, paranormal beliefs and emotional response bias in obsessive compulsive disorder patients. Method: The cross-sectional quasi-experimental study was conducted from November 2017 to November 2018 at the Government College University, Lahore, Pakistan, and comprised patients with obsessive compulsive disorder and healthy controls from the general population aged 20-40 years. Data was collected using the self-reporting Autism Spectrum Quotient, the Revised Paranormal Belief Scale, the Emotional Recognition Task and the Obsessive Compulsive Disorder symptom checklist. Data was analysed using SPSS 20. Results: Of the 140 participants, there were 70(50%) patients and as many controls. Overall, there were 72(52%) males and 68(48%) females. High level of autistic traits (p<0.001) and paranormal beliefs (p<0.001) had a significant impact on obsessive compulsive disorder. Impairments in recognition of emotions were related to the presence of high autistic traits and obsessive compulsive symptoms in the patients group (p<0.05). Emotion of disgust (p<0.001) was significantly impaired in the patients, while the differences were not significant in terms of emotions of happiness and surprise (p>0.05). Conclusion: Autistic traits, paranormal beliefs and emotional response bias were found to have a significant relationship in obsessive compulsive disorder patients.   Continuous....

Integrative Analysis of shared Genetic Pathogenesis by Autism Spectrum Disorder and Obsessive-Compulsive Disorder

2019 ◽  
Author(s):  
Dongbai Liu ◽  
Hongbao Cao ◽  
Kamil Can Kural ◽  
Qi Fang ◽  
Fuquan Zhang
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Large Scale ◽  
Genetic Network ◽  
Autism Spectrum ◽  
P Value ◽  
Genetic Associations ◽  
Obsessive Compulsive ◽  
Systematic Analysis ◽  
Gene Markers ◽  
Compulsive Disorder

Abstract Background Many common pathological features have been observed for both autism spectrum disorders (ASD) and obsessive-compulsive disorder (OCD). However, no systematic analysis of the common gene markers associated both ASD and OCD has been conducted so far. Results Here, two batches of large-scale literature based disease-gene relation data (updated in 2017 and 2019, respectively) and gene expression data were integrated to study the possible association between OCD and ASD at the genetic level. Genes linked to OCD and ASD present significant overlap (p-value<2.64e-39). A genetic network of over 20 genes was constructed, through which OCD and ASD may exert influence on each other. The 2017-based analysis suggested six potential common risk genes for OCD and ASD (CDH2, ADCY8, APOE, TSPO, TOR1A, and OLIG2), and the 2019-based study identified two more genes (DISP1 and SETD1A). Notably, the gene APOE identified by the 2017-based analysis has been implicated to have an association with ASD in a recently study (2018) with DNA methylation analysis. Conclusions Our results support the possible complex genetic associations between OCD and ASD. Genes linked to one disease is worthy of further investigation as potential risk factors for the other.

scholarly journals An Evaluation of a New Autism-Adapted Cognitive Behaviour Therapy Manual for Adolescents with Obsessive–Compulsive Disorder

2020 ◽  
Author(s):  
Amita Jassi ◽  
Lorena Fernández de la Cruz ◽  
Ailsa Russell ◽  
Georgina Krebs
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Cognitive Behaviour Therapy ◽  
Autism Spectrum ◽  
Behaviour Therapy ◽  
Obsessive Compulsive ◽  
Global Functioning ◽  
Compulsive Disorder ◽  
Cognitive Behaviour ◽  
Treatment Gains

Abstract Obsessive–compulsive disorder (OCD) and autism spectrum disorder (ASD) frequently co-occur. Standard cognitive behaviour therapy (CBT) for OCD outcomes are poorer in young people with ASD, compared to those without. The aim of this naturalistic study was to evaluate the effectiveness of a novel adolescent autism-adapted CBT manual for OCD in a specialist clinical setting. Additionally, we examined whether treatment gains were maintained at 3-month follow-up. Thirty-four adolescents underwent CBT; at the end of treatment, 51.51% were treatment responders and 21.21% were in remission. At 3-month follow-up, 52.94% were responders and 35.29% remitters. Significant improvements were also observed on a range of secondary measures, including family accommodation and global functioning. This study indicates this adapted package of CBT is associated with significant improvements in OCD outcomes, with superior outcomes to those reported in previous studies. Further investigation of the generalizability of these results, as well as dissemination to different settings, is warranted.

Adapted cognitive behavior therapy for obsessive–compulsive disorder with co-occurring autism spectrum disorder: A clinical effectiveness study

Autism ◽  
2019 ◽  
Vol 24 (1) ◽  
pp. 190-199
Author(s):  
Oskar Flygare ◽  
Erik Andersson ◽  
Helene Ringberg ◽  
Anna-Clara Hellstadius ◽  
Johan Edbacken ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Obsessive Compulsive Disorder ◽  
Behavior Therapy ◽  
Cognitive Behavior Therapy ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Cognitive Behavior ◽  
Obsessive Compulsive ◽  
Compulsive Disorder

Obsessive–compulsive disorder and autism spectrum disorder commonly co-occur. Adapted cognitive behavior therapy for obsessive–compulsive disorder in adults with autism spectrum disorder has not previously been evaluated outside the United Kingdom. In this study, 19 adults with obsessive–compulsive disorder and autism spectrum disorder were treated using an adapted cognitive behavior therapy protocol that consisted of 20 sessions focused on exposure with response prevention. The primary outcome was the clinician-rated Yale–Brown Obsessive–Compulsive Scale. Participants were assessed up to 3 months after treatment. There were significant reductions on the Yale–Brown Obsessive–Compulsive Scale at post-treatment (d = 1.5), and improvements were sustained at follow-up (d = 1.2). Self-rated obsessive–compulsive disorder and depressive symptoms showed statistically significant reductions. Improvements in general functioning and quality of life were statistically non-significant. Three participants (16%) were responders at post-treatment and four (21%) were in remission from obsessive–compulsive disorder. At follow-up, three participants (16%) were responders and one (5%) was in full remission. Adapted cognitive behavior therapy for obsessive–compulsive disorder in adults with co-occurring autism spectrum disorder is associated with reductions in obsessive–compulsive symptoms and depressive symptoms. However, outcomes are modest; few patients were completely symptom free, and treatment engagement was low with few completed exposures and low adherence to homework assignments. We identify and discuss the need for further treatment refinement for this vulnerable group.

A Case Report of Intensive Exposure-Based Cognitive Behavioral Therapy for a Child With Comorbid Autism Spectrum Disorder and Obsessive-Compulsive Disorder

2017 ◽  
Vol 31 (2) ◽  
pp. 118-123
Author(s):  
Katie L. Merricks ◽  
Joshua M. Nadeau ◽  
Amaya Ramos ◽  
Eric A. Storch
Keyword(s):  
Autism Spectrum Disorder ◽  
Cognitive Behavioral Therapy ◽  
Obsessive Compulsive Disorder ◽  
Treatment Modality ◽  
Behavioral Therapy ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Cognitive Behavioral ◽  
Obsessive Compulsive ◽  
Compulsive Disorder

Cognitive behavioral therapy (CBT) with exposure and response prevention (ERP) has proven to be an effective treatment modality for children with obsessive-compulsive disorder (OCD). Less research exists demonstrating efficacy for this treatment modality among children with comorbid diagnoses of OCD and autism spectrum disorder (ASD), and virtually, nothing has been reported examining intensive interventions for the most severe cases. As such, this article discusses the treatment of an adolescent male with severe OCD comorbid with ASD, attention deficit hyperactivity disorder (ADHD), generalized anxiety disorder (GAD), and chronic tic disorder using a cognitive behavioral approach and ERP. We conclude with recommendations for continued clinical research to understand approaches to help nonresponders to standard therapeutic approaches with this challenging population.

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