First trimester depression and/or anxiety disorders increase the risk of low birthweight in IVF offspring: a prospective cohort study

BackgroundNeonatal mortality is a major contributor worldwide to the number of deaths in children under 5 years of age. The primary objective of this study was to assess the overall mortality rate of babies with a birth weight equal or below 1500 g in a neonatal unit at a tertiary hospital in the Eastern Cape Province, South Africa. Furthermore, different maternal-related and infant-related factors for higher mortality were analysed.MethodsThis is a prospective cohort study which included infants admitted to the neonatal wards of the hospital within their first 24 hours of life and with a birth weight equal to or below 1500 g. Mothers who consented answered a questionnaire to identify factors for mortality.Results173 very low birth weight (VLBW) infants were recruited in the neonatal department between November 2017 and December 2018, of whom 55 died (overall mortality rate 32.0%). Twenty-three of the 44 infants (53,5%) with a birth weight below 1000 g died during the admission. One hundred and sixty-one mothers completed the questionnaire and 45 of their babies died.Main factors associated with mortality were lower gestational age and lower birth weight. Need for ventilator support and sepsis were associated with higher mortality, as were maternal factors such as HIV infection and age below 20 years.ConclusionThis prospective study looked at survival of VLBW babies in an underprivileged part of the Eastern Cape of South Africa. Compared with other public urban hospitals in the country, the survival rate remains unacceptably low. Further research is required to find the associated causes and appropriate ways to address these.

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Substance-induced psychosis as a risk factor for unipolar depression or anxiety disorders: A nationwide register-based prospective cohort study

Journal of Affective Disorders ◽

10.1016/j.jad.2021.09.004 ◽

2021 ◽

Author(s):

Carsten Hjorthøj ◽

Benjamin Arnfred ◽

Silke Behrendt ◽

Stine Bjerrum Møller ◽

Merete Nordentoft

Keyword(s):

Risk Factor ◽

Cohort Study ◽

Anxiety Disorders ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Unipolar Depression

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Gestational metabolic syndrome and neonatal anthropometric indices: a prospective cohort study

British Journal of Midwifery ◽

10.12968/bjom.2021.29.7.386 ◽

2021 ◽

Vol 29 (7) ◽

pp. 386-391

Author(s):

Zeinab Hatamian ◽

Lida Moghaddam-Banaem ◽

Samira Mokhlesi ◽

Marzieh Saei Ghare Naz

Keyword(s):

Metabolic Syndrome ◽

Cohort Study ◽

Birth Weight ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Linear Regression Analysis ◽

First Trimester ◽

P Value ◽

Anthropometric Parameters ◽

First Trimester Of Pregnancy

Background and aim There is limited knowledge about the effect of maternal metabolic syndrome (MetS) on the anthropometric parameters of newborns. Therefore, the authors aimed to evaluate the association between MetS in the first trimester of pregnancy with weight and height of the newborn. Methods This prospective cohort study was conducted on 455 pregnant women in Tehran during their first trimester of pregnancy. MetS was defined as the coexistence of three or more of the following criteria: fasting blood sugar (FBS) level ≥92 mg/dl, blood pressure ≥130.85 mm/hg, triglyceride ≥150 mg/dl, high density lipoprotein ≤50 mg/dl, and body mass index (BMI) ≥30 kg/m2. All participants were followed up to childbirth. After birth, the baby's weight and height data were collected from the birth certificate. Results Linear regression analysis showed FBS (ß: 0.100, p-value: 0.038), BMI (ß: 0.139, p-value: 0.004), and MetS (ß: -0.122, p-value: 0.015) were significantly associated with birth weight but no statistically significant results were found for birth height. Conclusion MetS and some of its components in pregnancy can affect birth weight of neonates.

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