Plasma acylcarnitines and risk of incident heart failure and atrial fibrillation: the Prevención con dieta mediterránea study

2021 ◽  
Author(s):  
Miguel Ruiz-Canela ◽  
Marta Guasch-Ferré ◽  
Cristina Razquin ◽  
Estefanía Toledo ◽  
Pablo Hernández-Alonso ◽  
...  
Keyword(s):  
Heart Failure ◽  
Atrial Fibrillation ◽  
Incident Heart Failure ◽  
Dieta Mediterranea ◽  
Dieta Mediterránea

scholarly journals High Plasma Glutamate and a Low Glutamine-to-Glutamate Ratio Are Associated with Increased Risk of Heart Failure but Not Atrial Fibrillation in the Prevención con Dieta Mediterránea (PREDIMED) Study

2020 ◽  
Vol 150 (11) ◽  
pp. 2882-2889 ◽  
Author(s):  
Christopher Papandreou ◽  
Pablo Hernández-Alonso ◽  
Mònica Bulló ◽  
Miguel Ruiz-Canela ◽  
Jun Li ◽  
...  
Keyword(s):  
Heart Failure ◽  
Atrial Fibrillation ◽  
Cardiometabolic Risk ◽  
High Plasma ◽  
Risk Profile ◽  
Cvd Risk ◽  
Increased Risk ◽  
Incident Cases ◽  
Dieta Mediterranea ◽  
Dieta Mediterránea

ABSTRACT Background Although the association between glutamate and glutamine in relation to cardiometabolic disorders has been evaluated, the role of these metabolites in the development of atrial fibrillation (AF) and heart failure (HF) remains unknown. Objectives We examined associations of glutamate, glutamine, and the glutamine-to-glutamate ratio with AF and HF incidence in a Mediterranean population at high cardiovascular disease (CVD) risk. Methods The present study used 2 nested case-control studies within the PREDIMED (Prevención con Dieta Mediterránea) study. During ∼10 y of follow-up, there were 509 AF incident cases matched to 618 controls and 326 HF incident cases matched to 426 controls. Plasma concentrations of glutamate and glutamine were semiquantitatively profiled with LC–tandem MS. ORs were estimated with multivariable conditional logistic regression models. Results In fully adjusted models, per 1-SD increment, glutamate was associated with a 29% (95% CI: 1.08, 1.54) increased risk of HF and glutamine-to-glutamate ratio with a 20% (95% CI: 0.67, 0.94) decreased risk. Glutamine-to-glutamate ratio was also inversely associated with HF risk (OR per 1-SD increment: 0.80; 95% CI: 0.67, 0.94) when comparing extreme quartiles. Higher glutamate concentrations were associated with a worse cardiometabolic risk profile, whereas a higher glutamine-to-glutamate ratio was associated with a better cardiometabolic risk profile. No associations between the concentrations of these metabolites and AF were observed. Conclusions Our findings suggest that high plasma glutamate concentrations possibly resulting from alterations in the glutamate-glutamine cycle may contribute to the development of HF in Mediterranean individuals at high CVD risk. This trial was registered at www.isrctn.com as ISRCTN35739639.

scholarly journals Assessment of Conventional Cardiovascular Risk Factors and Multiple Biomarkers for the Prediction of Incident Heart Failure and Atrial Fibrillation

2010 ◽  
Vol 56 (21) ◽  
pp. 1712-1719 ◽  
Author(s):  
J. Gustav Smith ◽  
Christopher Newton-Cheh ◽  
Peter Almgren ◽  
Joachim Struck ◽  
Nils G. Morgenthaler ◽  
...  
Keyword(s):  
Risk Factors ◽  
Heart Failure ◽  
Atrial Fibrillation ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Multiple Biomarkers ◽  
Incident Heart Failure

Change in Cardiac Biomarkers and Risk of Incident Heart Failure and Atrial Fibrillation in CKD: The Chronic Renal Insufficiency Cohort (CRIC) Study

2020 ◽  
Author(s):  
Nisha Bansal ◽  
Leila R. Zelnick ◽  
Elsayed Soliman ◽  
Amanda Anderson ◽  
Robert Christenson ◽  
...  
Keyword(s):  
Heart Failure ◽  
Atrial Fibrillation ◽  
Renal Insufficiency ◽  
Chronic Renal Insufficiency ◽  
Cardiac Biomarkers ◽  
Incident Heart Failure

scholarly journals Predictors and Prognostic Implications of Incident Heart Failure in Patients With Prevalent Atrial Fibrillation

2017 ◽  
Vol 5 (1) ◽  
pp. 44-52 ◽  
Author(s):  
Ambarish Pandey ◽  
Sunghee Kim ◽  
Curtiss Moore ◽  
Laine Thomas ◽  
Bernard Gersh ◽  
...  
Keyword(s):  
Heart Failure ◽  
Atrial Fibrillation ◽  
Incident Heart Failure ◽  
Prognostic Implications

scholarly journals Atrial Fibrillation in Patients With Cardiomyopathy: Prevalence and Clinical Outcomes From Real‐World Data

2021 ◽  
Author(s):  
Benjamin J. R. Buckley ◽  
Stephanie L. Harrison ◽  
Dhiraj Gupta ◽  
Elnara Fazio‐Eynullayeva ◽  
Paula Underhill ◽  
...  
Keyword(s):  
Heart Failure ◽  
Atrial Fibrillation ◽  
Clinical Outcomes ◽  
Restrictive Cardiomyopathy ◽  
The United States ◽  
Research Network ◽  
Real World Data ◽  
All Cause Mortality ◽  
Incident Heart Failure ◽  
The Impact

Background Cardiomyopathy is a common cause of atrial fibrillation (AF) and may also present as a complication of AF. However, there is a scarcity of evidence of clinical outcomes for people with cardiomyopathy and concomittant AF. The aim of the present study was therefore to characterize the prevalence of AF in major subtypes of cardiomyopathy and investigate the impact on important clinical outcomes. Methods and Results A retrospective cohort study was conducted using electronic medical records from a global federated health research network, with data primarily from the United States. The TriNetX network was searched on January 17, 2021, including records from 2002 to 2020, which included at least 1 year of follow‐up data. Patients were included based on a diagnosis of hypertrophic, dilated, or restrictive cardiomyopathy and concomitant AF. Patients with cardiomyopathy and AF were propensity‐score matched for age, sex, race, and comorbidities with patients who had a cardiomyopathy only. The outcomes were 1‐year mortality, hospitalization, incident heart failure, and incident stroke. Of 634 885 patients with cardiomyopathy, there were 14 675 (2.3%) patients with hypertrophic, 90 117 (7.0%) with restrictive, and 37 685 (5.9%) with dilated cardiomyopathy with concomitant AF. AF was associated with significantly higher odds of all‐cause mortality (odds ratio [95% CI]) for patients with hypertrophic (1.26 [1.13–1.40]) and dilated (1.36 [1.27–1.46]), but not restrictive (0.98 [0.94–1.02]), cardiomyopathy. Odds of hospitalization, incident heart failure, and incident stroke were significantly higher in all cardiomyopathy subtypes with concomitant AF. Among patients with AF, catheter ablation was associated with significantly lower odds of all‐cause mortality at 12 months across all cardiomyopathy subtypes. Conclusions Findings of the present study suggest AF may be highly prevalent in patients with cardiomyopathy and associated with worsened prognosis. Subsequent research is needed to determine the usefulness of screening and multisdisciplinary treatment of AF in this population.

Response to Letter Regarding Article, “Extravirgin Olive Oil Consumption Reduces Risk of Atrial Fibrillation: The PREDIMED (Prevención con Dieta Mediterránea) Trial”

Circulation ◽  
2015 ◽  
Vol 132 (10) ◽  
Author(s):  
Miguel Á. Martínez-González ◽  
Estefanía Toledo ◽  
Fernando Arós ◽  
Miquel Fiol ◽  
Dolores Corella ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Olive Oil ◽  
Oil Consumption ◽  
Dieta Mediterranea ◽  
Dieta Mediterránea

scholarly journals Risk assessment for incident heart failure in individuals with atrial fibrillation

2013 ◽  
Vol 15 (8) ◽  
pp. 843-849 ◽  
Author(s):  
Renate B. Schnabel ◽  
Michiel Rienstra ◽  
Lisa M. Sullivan ◽  
Jenny X. Sun ◽  
Carlee B. Moser ◽  
...  
Keyword(s):  
Heart Failure ◽  
Atrial Fibrillation ◽  
Risk Assessment ◽  
Incident Heart Failure

scholarly journals Associations between relevant cardiovascular pharmacotherapies and incident heart failure in patients with atrial fibrillation

2018 ◽  
Vol 36 (9) ◽  
pp. 1929-1935 ◽  
Author(s):  
Per Wändell ◽  
Axel C. Carlsson ◽  
Martin J. Holzmann ◽  
Johan Ärnlöv ◽  
Jan Sundquist ◽  
...  
Keyword(s):  
Heart Failure ◽  
Atrial Fibrillation ◽  
Incident Heart Failure

scholarly journals Left atrial hypertension and the risk of early incident heart failure after atrial fibrillation ablation

2020 ◽  
Author(s):  
Jasen L. Gilge ◽  
Asim Ahmed ◽  
Brad A. Clark ◽  
Alexander Slaten ◽  
Rahul Devathu ◽  
...  
Keyword(s):  
Heart Failure ◽  
Atrial Fibrillation ◽  
Left Atrial ◽  
Atrial Fibrillation Ablation ◽  
Incident Heart Failure
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