New treatment strategy for endometriosis using progestin-primed ovarian stimulation with dienogest: A prospective cohort study, comparison of dienogest versus dydrogesterone

AbstractPreviously anecdotally observed rebounds in follicle growth after interruption of exogenous gonadotropins in absolute non-responders were the impetus for here reported study. In a prospective cohort study, we investigated 49 consecutive patients, absolutely unresponsive to maximal exogenous gonadotropin stimulation, for a so-called rebound response to ovarian stimulation. A rebound response was defined as follicle growth following complete withdrawal of exogenous gonadotropin stimulation after complete failure to respond to maximal gonadotropin stimulation over up to 5–7 days. Median age of study patients was 40.5 ± 5.1 years (range 23–52). Women with and without rebound did not differ significantly (40.0 ± 6.0 vs. 41.0 ± 7.0 years, P = 0.41), with 24 (49.0%) recording a rebound and 25 (51.0%) not. Among the former, 21 (87.5%) reached retrieval of 1–3 oocytes and 15 (30.6%) reached embryo transfer. A successful rebound in almost half of prior non-responders was an unsuspected response rate, as was retrieval of 1–3 oocytes in over half of rebounding patients. Attempting rebounds may, thus, represent another incremental step in very poor prognosis patients before giving up on utilization of autologous oocytes. Here presented findings support further investigations into the underlying physiology leading to such an unexpectedly high rebound rate.

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HIV diagnosis period influences ART initiation: findings from a prospective cohort study in China

AIDS Research and Therapy ◽

10.1186/s12981-021-00379-3 ◽

2021 ◽

Vol 18 (1) ◽

Author(s):

Tinglong Yang ◽

Xueying Yang ◽

Linghua Li ◽

Huifang Xu ◽

Lirui Fan ◽

...

Keyword(s):

Cohort Study ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Cox Regression ◽

Hiv Diagnosis ◽

Initiation Rate ◽

Art Initiation ◽

Significant Difference ◽

New Strategy ◽

New Treatment

Abstract Background We estimated the predictive effects of ART-related perceptions on the actual ART uptake behavior among ART naïve PLWH stratified by different time of HIV diagnosis under the new strategy. Methods A prospective cohort study was conducted among ART naïve PLWH in Guangzhou, China from June 2016 to June 2017. Cox regression model was used to evaluate the predictive effects of ART-related perceptions on ART initiation among PLWH stratified by different timepoint of HIV diagnosis (i.e., before or after the update of the new treatment policy). Results Among 411 participants, 150 and 261 were diagnosed before (pre-scaleup group) and after (post-scaleup group) the implementation of the new strategy, respectively. The ART initiation rate in the post-scaleup group (88.9%) was higher than that in the pre-scaleup group (73.3%) (p < 0.001). A significant difference of mean score was detected in each HBM construct between pre- and post-scaleup groups (p < 0.05). After adjusting for significant background variables, among all participants, only the self-efficacy [adjusted HR (HRa) = 1.23, 95% CI 1.06 to 1.43, p = 0.006], has a predictive effect on ART initiation; in pre-scaleup group, all constructs of HBM-related ART perceptions were predictors of ART initiation (HRa = 0.71 to 1.83, p < 0.05), while in post-scaleup group, no significant difference was found in each construct (p > 0.05). Conclusions The ART initiation rate was high particularly among participants who diagnosed after the new treatment strategy. The important role of the time of HIV diagnosis on ART initiation identified in this study suggested that future implementation interventions may consider to modify the ART-related perceptions for HIV patients who diagnosed before the implementation of the new ART strategy, while expand the accessibility of ART service for those who diagnosed after the implementation of the new strategy.

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Non-Oral Poster 132: Oral Desmopressin: A New Treatment Option for Women with OAB? Preliminary Results of a Prospective Cohort Study

Journal of Pelvic Medicine and Surgery ◽

10.1097/01.spv.0000134140.46375.d8 ◽

2004 ◽

Vol 10 ◽

pp. S70

Author(s):

M Werner ◽

B Schuessler

Keyword(s):

Cohort Study ◽

Treatment Option ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Preliminary Results ◽

New Treatment

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A PROSPECTIVE COHORT STUDY TO DEVELOP A TREATMENT ALGORITHM FOR CONTROLLED OVARIAN STIMULATION TO SELECT A STARTING DOSE OF RECOMBINANT FOLLICLE STIMULATING HORMONE BASED ON PATIENT CHARACTERISTICS AND OVARIAN RESPONSE (FAME STUDY)

Fertility and Sterility ◽

10.1016/j.fertnstert.2021.07.538 ◽

2021 ◽

Vol 116 (3) ◽

pp. e196

Author(s):

Chang-Woo Choo ◽

Ji Hyang Kim

Keyword(s):

Cohort Study ◽

Prospective Cohort Study ◽

Ovarian Stimulation ◽

Prospective Cohort ◽

Follicle Stimulating Hormone ◽

Treatment Algorithm ◽

Ovarian Response ◽

Patient Characteristics ◽

Controlled Ovarian Stimulation ◽

Starting Dose

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Abstract P5-15-02: Safety of letrozole-gonadotropin controlled ovarian stimulation protocol in women with breast cancer undergoing fertility preservation before or after tumor resection via embryo or oocyte cryopreservation: A prospective cohort study

10.1158/1538-7445.sabcs14-p5-15-02 ◽

2015 ◽

Cited By ~ 3

Author(s):

Kutluk Oktay ◽

Jayeon Kim ◽

Giuliano Bedoschi ◽

Volkan Turan

Keyword(s):

Breast Cancer ◽

Cohort Study ◽

Fertility Preservation ◽

Prospective Cohort Study ◽

Ovarian Stimulation ◽

Prospective Cohort ◽

Tumor Resection ◽

Controlled Ovarian Stimulation ◽

Oocyte Cryopreservation ◽

Stimulation Protocol

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The Effect of Ovarian Stimulation on Endothelial Function—A Prospective Cohort Study using Peripheral Artery Tonometry

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/clinem/dgaa681 ◽

2020 ◽

Vol 105 (12) ◽

pp. e4722-e4729

Author(s):

Michal Kirshenbaum ◽

Jigal Haas ◽

Ravit Nahum ◽

Adva Aizer ◽

Yoav Yinon ◽

...

Keyword(s):

Cohort Study ◽

Endothelial Function ◽

Prospective Cohort Study ◽

Ovarian Stimulation ◽

Prospective Cohort ◽

Medical Center ◽

Reactive Hyperemia ◽

Peripheral Arterial Tonometry ◽

Follicular Maturation ◽

Arterial Tonometry

Abstract Context Gonadotropin-releasing hormone agonist (GnRH-a) serves as an alternative to human chorionic gonadotropin (hCG) to trigger final oocyte maturation, while it significantly reduces the risk of ovarian hyperstimulation syndrome (OHSS), probably by attenuating vascular/endothelial activation. Objectives The objectives of this work are to compare the effect of different modes of final follicular maturation (hCG vs GnRH-a) following ovarian stimulation (OS) for in vitro fertilization (IVF) on endothelial function. Design and Setting A prospective cohort study was conducted at a tertiary medical center. Participants Patients age 37 years or younger, undergoing OS for IVF, were allocated into 2 groups according to the type of final follicle maturation: the hCG group (n = 7) or the GnRH-a group (n = 8). Intervention Endothelial function was assessed by measurement of the peripheral arterial tonometry in reaction to temporary ischemia at 3 study points: day 3 of menstrual cycle (day 0), day of hCG/GnRH-a administration (day trigger) and day of oocyte pick-up (day OPU). The ratio of arterial tonometry readings before and after ischemia is called the reactive hyperemia index (RHI). Decreased RHI (< 1.67) indicates endothelial dysfunction. Main Outcome Measures The main outcomes measures of this study included endothelial function at 3 study points during OS with different modes of triggering final follicular maturation. Results The mean RHI values at day 0 were within the normal range for all patients and comparable between both groups (hCG: 1.7 ± 0.3 vs GnRH-a: 1.79 ± 0.4, P = .6). All patients presented a decrease in RHI values on day trigger, which did not differ between the 2 groups (1.62 ± 0.3 vs 1.4 ± 0.2, respectively, P = .2). However, the hCG group demonstrated a further decrease in RHI on day OPU, whereas patients who received GnRH-a had restored normal endothelial function reflected by increased RHI values (1.4 ± 0.2 vs 1.75 ± 0.2, respectively, P = .03). Conclusions Triggering final follicular maturation with GnRH-a restored normal endothelial function, whereas hCG trigger resulted in a decrease in endothelial function.

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HIV Diagnosis Time Differentiates ART Initiation: Implications from a Prospective Cohort Study in China

10.21203/rs.3.rs-117179/v1 ◽

2020 ◽

Author(s):

YANG Tinglong ◽

Xueying Yang ◽

Linghua Li ◽

Huifang Xu ◽

Lirui Fan ◽

...

Keyword(s):

Cohort Study ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Cox Regression ◽

Hiv Diagnosis ◽

Initiation Rate ◽

Art Initiation ◽

Significant Difference ◽

New Strategy ◽

New Treatment

Abstract Background: We estimated the predictive effects of ART-related perceptions on the actual ART uptake behavior among ART naïve PLWH stratified by different time of HIV diagnosis under the new strategy. Methods: A prospective cohort study was conducted among ART naïve PLWH in Guangzhou, China from June 2016 to June 2017. Cox regression model was used to evaluate the predictive effects of ART-related perceptions on ART initiation among PLWH stratified by different timepoint of HIV diagnosis (i.e., before or after the update of the new treatment policy). Results: Among 411 participants, 150 and 261 were diagnosed before (pre-scaleup group) and after (post-scaleup group) the implementation of the new strategy, respectively. The ART initiation rate in the post-scaleup group (88.9%) was higher than that in the pre-scaleup group (73.3%) (p<0.001). A significant difference of mean score was detected in each HBM construct between pre- and post- scaleup groups (p<0.05). After adjusting for significant background variables, among all participants, only the self-efficacy (adjusted HR (HRa) =1.23, 95% C.I.: 1.06 to 1.43, p=0.006), has a predictive effect on ART initiation; in pre-scaleup group, all constructs of HBM-related ART perceptions were predictors of ART initiation (HRa=0.71 to 1.83, p<0.05), while in post-scaleup group, no significant difference was found in each construct (p>0.05). Conclusions: The ART initiation rate was high particularly among participants who diagnosed after the new treatment strategy. The important role of the time of HIV diagnosis on ART initiation identified in this study suggested that future implementation interventions may consider to modify the ART-related perceptions for HIV patients who diagnosed before the implementation of the new ART strategy, while expand the accessibility of ART service for those who diagnosed after the implementation of the new strategy.

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