Oral two-generation reproduction toxicity study with NM-200 synthetic amorphous silica in Wistar rats

2015 ◽  
Vol 56 ◽  
pp. 147-154 ◽  
Author(s):  
André Wolterbeek ◽  
Thies Oosterwijk ◽  
Steffen Schneider ◽  
Robert Landsiedel ◽  
Didima de Groot ◽  
...  
Keyword(s):  
Amorphous Silica ◽  
Wistar Rats ◽  
Toxicity Study ◽  
Synthetic Amorphous Silica ◽  
Reproduction Toxicity

Oral prenatal developmental toxicity study with NM-200 synthetic amorphous silica in Wistar rats

2011 ◽  
Vol 32 (2) ◽  
pp. 173-174
Author(s):  
Steffen Schneider ◽  
Robert Landsiedel ◽  
Wendel Wohlleben ◽  
André Wolterbeek ◽  
Ine Waalkens-Berendsen ◽  
...  
Keyword(s):  
Amorphous Silica ◽  
Wistar Rats ◽  
Developmental Toxicity ◽  
Toxicity Study ◽  
Synthetic Amorphous Silica

scholarly journals Aerosols of synthetic amorphous silica do not induce fibrosis in lungs after inhalation: Pathology working group review of histopathological specimens from a subchronic 13-week inhalation toxicity study in rats

2018 ◽  
Vol 2 ◽  
pp. 239784731880527
Author(s):  
Klaus Weber ◽  
Axel Bosch ◽  
Mario Bühler ◽  
Chirukandath Gopinath ◽  
Jerry F Hardisty ◽  
...  
Keyword(s):  
Amorphous Silica ◽  
Working Group ◽  
Recovery Period ◽  
Toxicity Study ◽  
Inhalation Toxicity ◽  
Synthetic Amorphous Silica ◽  
Comparative Group ◽  
Quartz Dust ◽  
High Level ◽  
Dose Levels

In a subchronic (13-week) inhalation toxicity study with a terminal sacrifice (after 13 weeks inhalation) and several recovery period sacrifices (13, 26, 39, and 52 weeks), the effects of AEROSIL® 200 (pyrogenic synthetic amorphous silica (SAS)), AEROSIL® R 974 (surface-treated pyrogenic SAS), and SIPERNAT® 22 S (precipitated SAS) were tested in rats at multiple dose levels. The aforementioned materials are all SAS products. A comparative group of animals was exposed to quartz dust. This study attempts to reexamine the lung tissues originally evaluated in a study published by Reuzel et al. using the current standards. To reach a high level of credibility, the results of the reevaluation were subsequently examined by a pathology working group (PWG). In particular, the reevaluating pathologist and the PWG concluded that, even though quartz (crystalline silica) persisted, induced alterations in the lungs following 13 weeks of exposure to amorphous silicas were reversible following 52 weeks of recovery. A long-term adversity has not been established with SAS products. However, quartz dust damages lungs significantly by causing pulmonary fibrosis.

Two generation reproduction toxicity study of GmDREB3 gene modified wheat in Wistar rats

2021 ◽  
pp. 112310
Author(s):  
Jie Tian ◽  
Xianghong Ke ◽  
Yuan Yuan ◽  
Wenxiang Yang ◽  
Xiaoqiao Tang ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Toxicity Study ◽  
Reproduction Toxicity

Oral two-generation reproduction study with NM-200 synthetic amorphous silica in Wistar rats

2011 ◽  
Vol 32 (2) ◽  
pp. 178
Author(s):  
André Wolterbeek ◽  
Ine Waalkens-Berendsen ◽  
Steffen Schneider ◽  
Robert Landsiedel ◽  
Didima de Groot ◽  
...  
Keyword(s):  
Amorphous Silica ◽  
Wistar Rats ◽  
Synthetic Amorphous Silica ◽  
Reproduction Study

Subacute inhalation toxicity study of synthetic amorphous silica nanoparticles in Sprague-Dawley rats

2017 ◽  
Vol 29 (12-14) ◽  
pp. 567-576 ◽  
Author(s):  
Jae Hoon Shin ◽  
KiSoo Jeon ◽  
Jin Kwon Kim ◽  
Younghun Kim ◽  
Mi Seong Jo ◽  
...  
Keyword(s):  
Silica Nanoparticles ◽  
Amorphous Silica ◽  
Toxicity Study ◽  
Inhalation Toxicity ◽  
Sprague Dawley ◽  
Sprague Dawley Rats ◽  
Synthetic Amorphous Silica

Toxicity Study of Swarna Bhasma, an Ayurvedic Medicine Containing Gold, in Wistar Rats

2015 ◽  
Vol 22 (3) ◽  
pp. 11 ◽  
Author(s):  
Pallavi Shrirang Jamadagni ◽  
Shrirang B. Jamadagni ◽  
Arjun Singh ◽  
Rajendra Kumar Singh ◽  
Sachchidanand N. Upadhyay ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Toxicity Study ◽  
Ayurvedic Medicine

scholarly journals Insights on toxicity, safe handling and disposal of silica aerogels and amorphous nanoparticles

2021 ◽  
Author(s):  
João P. Vareda ◽  
Carlos A. García-González ◽  
Artur J. M. Valente ◽  
Rosana Simón-Vázquez ◽  
Marina Stipetic ◽  
...  
Keyword(s):  
Silica Nanoparticles ◽  
Amorphous Silica ◽  
Silica Aerogels ◽  
Safe Handling ◽  
Synthetic Amorphous Silica ◽  
Amorphous Nanoparticles

The toxicity and ecotoxicity effects, handling and disposal of synthetic amorphous silica nanoparticles and aerogels are reviewed and discussed.

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