scholarly journals Role of aryl hydrocarbon receptor (AHR) in overall retinoid metabolism: Response comparisons to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure between wild-type and AHR knockout mice

2021 ◽  
Vol 101 ◽  
pp. 33-49
Author(s):  
Javier Esteban ◽  
Ismael Sánchez-Pérez ◽  
Gerd Hamscher ◽  
Hanna M. Miettinen ◽  
Merja Korkalainen ◽  
...  
Keyword(s):  
Aryl Hydrocarbon Receptor ◽  
Knockout Mice ◽  
Wild Type ◽  
Aryl Hydrocarbon ◽  
Retinoid Metabolism ◽  
Tetrachlorodibenzo P Dioxin

Role of the aryl hydrocarbon receptor and Cyp1b1 in the antiestrogenic activity of 2,3,7,8-tetrachlorodibenzo- p -dioxin

2004 ◽  
Vol 78 (6) ◽  
pp. 309-315 ◽  
Author(s):  
Kei Takemoto ◽  
Miki Nakajima ◽  
Yuto Fujiki ◽  
Miki Katoh ◽  
Frank J. Gonzalez ◽  
...  
Keyword(s):  
Aryl Hydrocarbon Receptor ◽  
Aryl Hydrocarbon ◽  
Antiestrogenic Activity ◽  
Tetrachlorodibenzo P Dioxin

ROLE OF THE ARYL HYDROCARBON RECEPTOR IN THE DEVELOPMENT OF CONTROL AND 2,3,7,8-TETRACHLORODIBENZO-p-DIOXIN-EXPOSED MALE MICE

2001 ◽  
Vol 64 (4) ◽  
pp. 327-342 ◽  
Author(s):  
Tien-Min Lin ◽  
Kinarm Ko ◽  
Robert W. Moore ◽  
David L. Buchanan ◽  
Paul S. Cooke ◽  
...  
Keyword(s):  
Aryl Hydrocarbon Receptor ◽  
Male Mice ◽  
Aryl Hydrocarbon ◽  
Tetrachlorodibenzo P Dioxin

scholarly journals The Unexpected Role for the Aryl Hydrocarbon Receptor on Susceptibility to Experimental Toxoplasmosis

2010 ◽  
Vol 2010 ◽  
pp. 1-15 ◽  
Author(s):  
Yuriko Sanchez ◽  
Juan de Dios Rosado ◽  
Libia Vega ◽  
Guillermo Elizondo ◽  
Elizabeth Estrada-Muñiz ◽  
...  
Keyword(s):  
Aryl Hydrocarbon Receptor ◽  
Serum Levels ◽  
Wild Type ◽  
Signaling System ◽  
Spleen Cells ◽  
Tlr2 Expression ◽  
Aryl Hydrocarbon ◽  
Intraperitoneal Infection ◽  
Necrosis Factor

The aryl hydrocarbon receptor (AhR) is part of a signaling system that is mainly triggered by xenobiotic agents. Increasing evidence suggests that AhR may regulate immunity to infections. To determine the role of AhR in the outcome of toxoplasmosis, we used AhR-/- and wild-type (WT) mice. Following an intraperitoneal infection withToxoplasma gondii(T. gondii), AhR-/- mice succumbed significantly faster than WT mice and displayed greater liver damage as well as higher serum levels of tumor necrosis factor (TNF)-α, nitric oxide (NO), and IgE but lower IL-10 secretion. Interestingly, lower numbers of cysts were found in their brains. Increased mortality was associated with reduced expression of GATA-3, IL-10, and 5-LOX mRNA in spleen cells but higher expression of IFN-γmRNA. Additionally, peritoneal exudate cells from AhR-/- mice produced higher levels of IL-12 and IFN-γbut lower TLR2 expression than WT mice. These findings suggest a role for AhR in limiting the inflammatory response during toxoplasmosis.

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