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Madhuca longifolia (J.Koenig) J.F.Macbr. belongs to the family Sapotaceae, also commonly known as mahua or butternut tree. Each part of the plant is known for its unique medicinal properties. This review aims to enhance the existence of application and extend the therapeutic potential of Madhuca species in Pharmaceuticals, cosmeceuticals, agriculture and the food industry. Madhuca longifolia and all its products are widely used as a traditional and herbal medicine system. Even though they are used traditionally by a population of local areas, the potential of therapeutic existence is still uncovered. This systematic review is an exhaustive compilation of detailed data on phytochemistry, wide ethnopharmacological uses, medicinal properties and commercial application of mahua in different sectors. With the potential of spasmogenic, oxytocic, uterotonic, anti-bacterial, anti implantation, anti-tumor, anti-progestational, antiestrogenic activity against menorrhagia and anti-cancer, and many more. M. longifolia is also used in stomach ache, snake bite, scorpion bite, bone fractures, treatment of piles, joint pains, increase lactation, etc. It can contribute towards the development of the pharmaceutical sector and food industry too. Positively it will provide a path for future research for the development of herbal drugs and other products for agriculture and the food industry.