Could maternal thyroid function during pregnancy affect daughters’ age at menarche through child growth? A mediation analysis

2022 ◽  
Vol 107 ◽  
pp. 33-39
Author(s):  
Eva L. Siegel ◽  
Katrina L. Kezios ◽  
Lauren Houghton ◽  
Camila Pereira-Eshraghi ◽  
Piera Cirillo ◽  
...  
Keyword(s):  
Thyroid Function ◽  
Mediation Analysis ◽  
Child Growth ◽  
Age At Menarche ◽  
Maternal Thyroid

Careful Assessment of Maternal Thyroid Function Can Prevent Cases of Fetal Goitrous Hypothyroidism

2013 ◽  
Vol 34 (1) ◽  
pp. 66-68 ◽  
Author(s):  
Sofie Bliddal ◽  
Åse Krogh Rasmussen ◽  
Karin Sundberg ◽  
Ulla Feldt-Rasmussen
Keyword(s):  
Thyroid Function ◽  
Maternal Thyroid ◽  
Careful Assessment

scholarly journals A Novel Nomogram for Predicting the Risk of Premature Delivery Based on the Thyroid Function in Pregnant Women

2022 ◽  
Vol 12 ◽  
Author(s):  
Yu Meng ◽  
Jing Lin ◽  
Jianxia Fan
Keyword(s):  
Risk Factors ◽  
Pregnant Women ◽  
Preterm Delivery ◽  
Thyroid Function ◽  
Premature Delivery ◽  
Multivariable Logistic Regression Analysis ◽  
Decision Curve Analysis ◽  
Cutoff Values ◽  
Lemeshow Test ◽  
Maternal Thyroid

BackgroundMaternal thyroid dysfunction and autoantibodies were associated with preterm delivery. However, recommendations for cutoff values of thyroperoxidase antibody (TPOAb) positivity and thyroid-stimulating homone (TSH) associated with premature delivery are lacking.ObjectiveTo identify the pregnancy-specific cutoff values for TPOAb positivity and TSH associated with preterm delivery. To develop a nomogram for the risk prediction of premature delivery based on maternal thyroid function in singleton pregnant women without pre-pregnancy complications.MethodsThis study included data from the International Peace Maternity and Child Care Health Hospital (IPMCH) in Shanghai, China, between January 2013 and December 2016. Added data between September 2019 and November 2019 as the test cohort. Youden’s index calculated the pregnancy-specific cutoff values for TPOAb positivity and TSH concentration. Univariate and multivariable logistic regression analysis were used to screen the risk factors of premature delivery. The nomogram was developed according to the regression coefficient of relevant variables. Discrimination and calibration of the model were assessed using the C-index, Hosmer-Lemeshow test, calibration curve and decision curve analysis.Results45,467 pregnant women were divided into the training and validation cohorts according to the ratio of 7: 3. The testing cohort included 727 participants. The pregnancy-specific cutoff values associated with the risk of premature delivery during the first trimester were 5.14 IU/mL for TPOAb positivity and 1.33 mU/L for TSH concentration. Multivariable logistic regression analysis showed that maternal age, history of premature delivery, elevated TSH concentration and TPOAb positivity in the early pregnancy, preeclampsia and gestational diabetes mellitus were risk factors of premature delivery. The C-index was 0.62 of the nomogram. Hosmer-Lemeshow test showed that the Chi-square value was 2.64 (P = 0.955 > 0.05). Decision curve analysis showed a positive net benefit. The calibration curves of three cohorts were shown to be in good agreement.ConclusionsWe identified the pregnancy-specific cutoff values for TPOAb positivity and TSH concentration associated with preterm delivery in singleton pregnant women without pre-pregnancy complications. We developed a nomogram to predict the occurrence of premature delivery based on thyroid function and other risk factors as a clinical decision-making tool.

Maternal thyroid function during pregnancy and child brain morphology: a time window-specific analysis of a prospective cohort

2019 ◽  
Vol 7 (8) ◽  
pp. 629-637 ◽  
Author(s):  
Toyah A Jansen ◽  
Tim I M Korevaar ◽  
Tessa A Mulder ◽  
Tonya White ◽  
Ryan L Muetzel ◽  
...  
Keyword(s):  
Thyroid Function ◽  
Prospective Cohort ◽  
Time Window ◽  
Brain Morphology ◽  
Specific Analysis ◽  
Maternal Thyroid

Maternal Thyroid Function, Use of Antithyroid Drugs in Early Pregnancy, and Birth Defects

2019 ◽  
Vol 104 (12) ◽  
pp. 6040-6048 ◽  
Author(s):  
Stine Linding Andersen ◽  
Louise Knøsgaard ◽  
Jørn Olsen ◽  
Peter Vestergaard ◽  
Stig Andersen
Keyword(s):  
Thyroid Function ◽  
Birth Defects ◽  
Early Pregnancy ◽  
Antithyroid Drug ◽  
Maternal Blood ◽  
Antithyroid Drugs ◽  
Birth Cohorts ◽  
Increased Risk ◽  
Maternal Thyroid

Abstract Context Antithyroid drug (ATD) therapy in early pregnancy is associated with birth defects, but more data are needed to substantiate the risk associated with different types of ATD. Furthermore, the role of abnormal maternal thyroid function per se remains unclarified. Objective To evaluate the risk of birth defects associated with the use of ATD in an extended nationwide cohort and the role of abnormal maternal thyroid function in birth cohorts including stored maternal blood samples from early pregnancy. Participants Danish pregnant women and their live-born children, including 1,243,353 children from a Nationwide Register-Based Cohort (NRBC), 1997 to 2016; 8830 children from the Danish National Birth Cohort (DNBC), 1997 to 2003; and 14,483 children from the North Denmark Region Pregnancy Cohort (NDRPC), 2011 to 2015. Main Outcome Measures Birth defects diagnosed before 2 years of age. Results In the NRBC, altogether 2718 (0.2%) children had been exposed to ATD in early pregnancy. The overall frequency of birth defects was 6.7% (95% CI, 6.7% to 6.8%) in nonexposed children and higher after exposure to methimazole/carbimazole (9.6%; 95% CI, 8.2% to 11.2%) and propylthiouracil (8.3%; 95% CI, 6.7% to 10.3%). On the other hand, the frequency of maternal thyroid dysfunction in early pregnancy was similar in the random cohort and in cases of birth defect in the DNBC (12.4 vs 12.6%, P = 0.8) and the NDRPC (15.1 vs 15.4%, P = 0.8). Conclusions Results corroborate an increased risk of birth defects associated with the use of ATD in early pregnancy and suggest that abnormal maternal thyroid function is not a major risk factor for birth defects.

Maternal Thyroid Function Does Not Alter Maternal Serum α-Fetoprotein Interpretation

1997 ◽  
Vol 6 (2) ◽  
pp. 115-117
Author(s):  
Mordechai Hallak ◽  
Joseph E. O'brien ◽  
Nelson B. Isada ◽  
Mark P. Johnson ◽  
Arie Drugan ◽  
...  
Keyword(s):  
Thyroid Function ◽  
Maternal Serum ◽  
Maternal Thyroid

Influence of iodine status on maternal thyroid function during pregnancy

2017 ◽  
Vol 64 (6) ◽  
pp. 331-333
Author(s):  
David Ruiz Ochoa ◽  
María Piedra León ◽  
Bernardo Alio Lavín Gómez ◽  
Carmela Baamonde Calzada ◽  
María Teresa García Unzueta ◽  
...  
Keyword(s):  
Thyroid Function ◽  
Iodine Status ◽  
Maternal Thyroid

scholarly journals Maternal thyroid function in pregnancy may program offspring blood pressure, but not adiposity at 20 y of age

2016 ◽  
Vol 80 (1) ◽  
pp. 7-13 ◽  
Author(s):  
Dorte Rytter ◽  
Stine L. Andersen ◽  
Bodil H. Bech ◽  
Thorhallur I. Halldorsson ◽  
Tine B. Henriksen ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Thyroid Function ◽  
Maternal Thyroid ◽  
In Pregnancy
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