scholarly journals The prognostic value of the COPD Assessment Test in fibrotic interstitial lung disease

Author(s):  
Toshiaki Matsuda ◽  
Yasuhiro Kondoh ◽  
Taiki Furukawa ◽  
Atsushi Suzuki ◽  
Reoto Takei ◽  
...  
Author(s):  
Stefano Grecuccio ◽  
◽  
Nicola Sverzellati ◽  
Elisabetta Uslenghi ◽  
Antonella Caminati ◽  
...  

2019 ◽  
Vol 150 ◽  
pp. 15-20 ◽  
Author(s):  
Atsushi Suzuki ◽  
Yasuhiro Kondoh ◽  
Jeffrey James Swigris ◽  
Toshiaki Matsuda ◽  
Tomoki Kimura ◽  
...  

CHEST Journal ◽  
2014 ◽  
Vol 145 (4) ◽  
pp. 672-674 ◽  
Author(s):  
Athol U. Wells ◽  
Katerina M. Antoniou

2013 ◽  
Vol 107 (5) ◽  
pp. 745-752 ◽  
Author(s):  
Kiminobu Tanizawa ◽  
Tomohiro Handa ◽  
Ran Nakashima ◽  
Takeshi Kubo ◽  
Yuji Hosono ◽  
...  

Author(s):  
Fujiko Someya ◽  
Takao Nakagawa ◽  
Naoki Mugii

The chronic obstructive pulmonary disease (COPD) Assessment Test (CAT), which was developed to measure the health status of patients with COPD, was applied to patients with interstitial lung disease, aiming to examine the CAT as a predictor of outcome. Over a follow-up period of more than one year, 101 consecutive patients with interstitial lung disease were evaluated by the CAT. The CAT scores of 40 in total were categorized into four subsets according to the severity. Patients with higher (more severe) scores exhibited lower forced vital capacity and lung diffusion capacity for carbon monoxide. The survival rate was significantly lower in patients with higher scores (log-rank test, P = 0.0002), and the hazard ratios for death of the higher scores and lower lung diffusion capacity for carbon monoxide were independently significant. These findings suggest that CAT can indicate the risk of mortality in patients with interstitial lung disease.


2020 ◽  
Vol 6 (3) ◽  
pp. 00027-2020
Author(s):  
Shaney L. Barratt ◽  
Richard Davis ◽  
Charles Sharp ◽  
John D. Pauling

The heterogeneity of interstitial lung disease (ILD) results in prognostic uncertainty concerning end-of-life discussions and optimal timing for transplantation. Effective prognostic markers and prediction models are needed. Cardiopulmonary exercise testing (CPET) provides a comprehensive assessment of the physiological changes in the respiratory, cardiovascular and musculoskeletal systems in a controlled laboratory environment. It has shown promise as a prognostic factor for other chronic respiratory conditions. We sought to evaluate the prognostic value of CPET in predicting outcomes in longitudinal studies of ILD.MEDLINE, Embase and the Cochrane Database of Systematic Reviews were used to identify studies reporting the prognostic value of CPET in predicting outcomes in longitudinal studies of ILD. Study quality was assessed using the Quality in Prognosis Study risk of bias tool.Thirteen studies were included that reported the prognostic value of CPET in ILD. All studies reported at least one CPET parameter predicting clinical outcomes in ILD, with survival being the principal outcome assessed. Maximum oxygen consumption, reduced ventilatory efficiency and exercise-induced hypoxaemia were all reported to have prognostic value in ILD. Issues with study design (primarily due to inherent problems of retrospective studies, patient selection and presentation of numerous CPET parameters), insufficient adjustment for important confounders and inadequate statistical analyses limit the strength of the conclusions that can be drawn at this stage.There is insufficient evidence to confirm the value of CPET in facilitating “real-world” clinical decisions in ILD. Additional prospective studies are required to validate the putative prognostic associations reported in previous studies in carefully phenotyped patient populations.


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