Intranasal or oral Lactobacilli administration: Which one is best for fighting against Pseudomonas aeruginosa (PA) respiratory tract infections?

2021 ◽  
Vol 38 (6) ◽  
pp. 583
Author(s):  
R. Lagrafeuille ◽  
M.S. Fangous ◽  
C.A. Guilloux ◽  
S. Gouriou ◽  
P. Gosset ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Respiratory Tract ◽  
Respiratory Tract Infections ◽  
Tract Infections

scholarly journals Predominance of Bacterial Flora Causing Lower Respiratory Tract Infections Following Tracheostomy in Patients of Chettinad Hospital & Research Institute, Chennai, India

2021 ◽  
Vol 10 (35) ◽  
pp. 2964-2968
Author(s):  
Swetha Thirumurthi ◽  
Priya Kanagamuthu ◽  
Rajasekaran Srinivasan ◽  
Bhalaji Dhanasekaran
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Respiratory Tract ◽  
Lower Respiratory Tract ◽  
Respiratory Tract Infections ◽  
Antibiotic Sensitivity ◽  
Klebsiella Pneumonia ◽  
Lower Respiratory Tract Infections ◽  
Empirical Antibiotics ◽  
Tract Infections ◽  
Research Institute

BACKGROUND The term tracheostomy refers to forming an opening in the trachea.1,2 Its advantages include easy and direct access to lower respiratory tract, reduced risk of aspiration, faster weaning from ventilation support and improved physical and psychological comfort. But a common problem in tracheostomised patients is increased risk of colonisation of lower respiratory tract by exogenous bacteria because of direct exposure.1,3 This study was done to recognise pathogens in tracheal secretions collected from tracheostomised patients and their antibiotic sensitivity to treat them with appropriate antibiotics. METHODS This prospective study was done in 138 tracheostomised patients from October 2020 to March 2021 in intensive care unit (ICU) of Chettinad Hospital and Research Institute. Under sterile aseptic precautions, Day 0 and Day 7 cultures posttracheostomy was obtained and their antibiotic sensitivity was studied. Data was analysed using Statistical Package for Social Sciences (SPSS version 19) and presented in proportion, mean and standard deviation (Descriptive statistics). RESULTS In this study, of the 56 cases who had growth in their culture and sensitivity reports on day 0, the most common organism was Pseudomonas aeruginosa (33.9 %) sensitive to imipenem (94.7 %) followed by klebsiella (25 %) sensitive to teicoplanin, vancomycin, amikacin, cefoperazone/tazobactam, linezolid and piperacillin/tazobactam. On day 7, the growth of organisms isolated in tracheal culture got reduced from 56 cases to 16 cases. The prevalence of Pseudomonas reduced to 18.8 % in day 7 whereas Klebsiella pneumonia and Acinetobacter remained almost same from day 0 to day 7. CONCLUSIONS This study concludes the predominant pathogen as Pseudomonas aeruginosa with sensitivity to imipenem followed by Klebsiella with sensitivity to teicoplanin, vancomycin, amikacin, cefoperazone/tazobactam, linezolid and piperacillin/tazobactam on day 0 with reduction in the number of organisms on day 7 due to the fact that all our patients were admitted in ICU several days prior to tracheostomy and were started on antibiotics soon after admission as per choice of the treating physician. Hence, a clear understanding of bacterial colonisation post tracheostomy and its change in course is essential for timely intervention with empirical antibiotics for reducing the incidence of lower respiratory tract infections after tracheostomy in future. KEY WORDS Tracheostomy, Lower Respiratory Tract Infections, Pseudomonas Aeruginosa, Empirical Antibiotics.

Mucoid and Nonmucoid Pseudomonas aeruginosa Isolated from Respiratory Tract Infections

2016 ◽  
Vol 1 (2) ◽  
pp. 43-45
Author(s):  
Ved Prakash ◽  
Prem P Mishra
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Respiratory Tract ◽  
High Resistance ◽  
Respiratory Tract Infections ◽  
Antibiotic Sensitivity ◽  
Resistance Rate ◽  
Susceptibility Pattern ◽  
Antibiotic Susceptibility Pattern ◽  
Clinical Specimens ◽  
Tract Infections

ABSTRACT Introduction Pseudomonas aeruginosa is a common etiological agent causing various infections. The isolates can be mucoid or nonmucoid. It harbors innate resistance to a broad range of antibiotics. Objectives The aim of this study is to determine the frequency of the mucoid and nonmucoid isolates along with their antibiogram from respiratory samples. Materials and methods A total of 220 isolates of P. aeruginosa were obtained from various clinical specimens and 72 from respiratory samples. Pseudomonas aeruginosa was identified by standard colony morphology and bacteriological methods, and antibiotic sensitivity was determined by the Kirby Bauer method. Results Out of the 72 respiratory samples, 15 (20.83%) were mucoid strains and 57 (79.87%) nonmucoid strains. The mucoid colonies showed high resistance to antibiotics, such as co-trimoxazole (COT) (73.33%), ciprofloxacin (CIP) (60%), and ceftazidime (CAZ) (53.33%), whereas high resistance rate among the nonmucoid isolates were seen in (COT) (78.95%), (CIP) (71.93%), (CAZ) (54.39%), cefepime (52.63%). Conclusion The antibiotic susceptibility pattern helps in constituting the guidelines for treatment and management of the infections by P. aeruginosa. How to cite this article Mishra PP, Prakash V. Mucoid and Nonmucoid Pseudomonas aeruginosa Isolated from Respiratory Tract Infections. Int J Adv Integ Med Sci 2016;1(2):43-45.

Sign in / Sign up

Export Citation Format

Share Document