D-optimal design as a useful tool response surface methodology for the optimization of signals from synchronous fluorescence prior to simultaneous determination of avanafil and tadalafil

2020 ◽  
Vol 235 ◽  
pp. 118313 ◽  
Author(s):  
Ahmed M. Abdel-Raoof ◽  
Ragab A.M. Said ◽  
Mohamed S. Emara ◽  
Ebrahim A. El-Desouky ◽  
Ahmed M. Abdelzaher ◽  
...  
Keyword(s):  
Response Surface Methodology ◽  
Optimal Design ◽  
Response Surface ◽  
Simultaneous Determination ◽  
Synchronous Fluorescence

Multivariate Optimization of Separation Conditions for Simultaneous Determination of Acemetacin and Chlorzoxazone in a Pharmaceutical Preparation by HPLC Using Response Surface Methodology

2013 ◽  
Vol 96 (4) ◽  
pp. 723-729
Author(s):  
Cigdem Aybaba ◽  
Ismail Murat Palabiyik ◽  
Mehmet Gokhan Caglayan ◽  
Feyyaz Onur
Keyword(s):  
Response Surface Methodology ◽  
Response Surface ◽  
Simultaneous Determination ◽  
Mobile Phase ◽  
Ammonium Acetate ◽  
Pharmaceutical Preparation ◽  
Internal Standard ◽  
Hplc Method ◽  
Optimum Separation

Abstract A new, fast, accurate, precise, and sensitive RP-HPLC method for the simultaneous determination of acemetacin and chlorzoxazone has been developed. Response surface methodology with a central composite design was used to optimize the acetonitrile and ammonium acetate percentage in the mobile phase and pH of ammonium acetate. The optimum separation was achieved on a C18 column (250 × 4.6 mm id, 5 μm particle size) using the mobile phase methanol–acetonitrile–0.02 M ammonium acetate, pH 9.4 (25 + 35 + 40, v/v/v) at a flow rate of 1.5 mL/min; UV detection at 270 nm, and cyanocobalamin as an internal standard. This developed method was validated and successfully applied to a coated tablet pharmaceutical preparation.

scholarly journals Second derivative synchronous fluorescence determination of avanafil in the presence of its acid-induced degradation product aided by powerful Lean Six Sigma tools augmented with D-optimal design

RSC Advances ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 3834-3842
Author(s):  
Khalid A. M. Attia ◽  
Ahmad A. Mohamad ◽  
Mohamed S. Emara ◽  
Ahmed M. Abdel-Raoof ◽  
Mohamed A. Hasan ◽  
...  
Keyword(s):  
Optimal Design ◽  
Quantitative Determination ◽  
Degradation Product ◽  
Six Sigma ◽  
Lean Six Sigma ◽  
Synchronous Fluorescence ◽  
Second Derivative ◽  
Fluorescence Determination ◽  
Spectrofluorimetric Method

In this work, the quantitative determination of an erectile dysfunctional drug avanafil in the presence of its acid-induced degradation product was achieved via the application of a pre-optimized novel spectrofluorimetric method.

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