scholarly journals Application of HPLC and response surface methodology for simultaneous determination of curcumin and desmethoxy curcumin in Curcuma syrup formulation

2017 ◽  
Keyword(s):  
Response Surface Methodology ◽  
Response Surface ◽  
Simultaneous Determination

Multivariate Optimization of Separation Conditions for Simultaneous Determination of Acemetacin and Chlorzoxazone in a Pharmaceutical Preparation by HPLC Using Response Surface Methodology

2013 ◽  
Vol 96 (4) ◽  
pp. 723-729
Author(s):  
Cigdem Aybaba ◽  
Ismail Murat Palabiyik ◽  
Mehmet Gokhan Caglayan ◽  
Feyyaz Onur
Keyword(s):  
Response Surface Methodology ◽  
Response Surface ◽  
Simultaneous Determination ◽  
Mobile Phase ◽  
Ammonium Acetate ◽  
Pharmaceutical Preparation ◽  
Internal Standard ◽  
Hplc Method ◽  
Optimum Separation

Abstract A new, fast, accurate, precise, and sensitive RP-HPLC method for the simultaneous determination of acemetacin and chlorzoxazone has been developed. Response surface methodology with a central composite design was used to optimize the acetonitrile and ammonium acetate percentage in the mobile phase and pH of ammonium acetate. The optimum separation was achieved on a C18 column (250 × 4.6 mm id, 5 μm particle size) using the mobile phase methanol–acetonitrile–0.02 M ammonium acetate, pH 9.4 (25 + 35 + 40, v/v/v) at a flow rate of 1.5 mL/min; UV detection at 270 nm, and cyanocobalamin as an internal standard. This developed method was validated and successfully applied to a coated tablet pharmaceutical preparation.

scholarly journals Determination of Optimum Composition of Fermentation Medium for Citric Acid Production from Watermelon Rinds using Response Surface Methodology

2017 ◽  
Vol 1 (1) ◽  
pp. 12-16
Author(s):  
Andrew Amenaghawon ◽  
◽  
Oluwatoba Salokun ◽  
Justina Okhonmina ◽  
Imuetinyan Egharevba ◽  
...  
Keyword(s):  
Response Surface Methodology ◽  
Citric Acid ◽  
Response Surface ◽  
Acid Production ◽  
Fermentation Medium ◽  
Optimum Composition ◽  
Citric Acid Production
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